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NELFINAVIR

Product Name
NELFINAVIR
CAS No.
159989-64-7
Chemical Name
NELFINAVIR
Synonyms
AG 1341;nefinavir;NELFINAVIR;NELFINAVIR-12;Nelfinavir D5;8a-beta))-a-bet;NELFINAVIR iMpurity;NELFINAVIR USP/EP/BP;Nelfinavir (AG-1341);Nelfinavir Regeoisomer
CBNumber
CB8213806
Molecular Formula
C32H45N3O4S
Formula Weight
567.78
MOL File
159989-64-7.mol
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NELFINAVIR Property

Melting point:
185-186 °C
Boiling point:
786.8±60.0 °C(Predicted)
alpha 
D -119.23° (c = 0.26 in methanol)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
≥ 20.45mg/mL in Ethanol
form 
Powder
pka
pKa1 6.0; pKa2 11.06(at 25℃)
Water Solubility 
7g/L(temperature not stated)
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Safety

Toxicity
rat,LD,oral,> 5gm/kg (5000mg/kg),Toxicologist. Vol. 42, Pg. 55, 1998.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B1122
Product name
Nelfinavir
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0677
Product name
Nelfinavir
Purity
96.90%
Packaging
5mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
E178
Product name
Nelfinavir
Packaging
2mg
Price
$139
Updated
2021/12/16
ChemScene
Product number
CS-0677
Product name
Nelfinavir
Purity
96.90%
Packaging
10mg
Price
$140
Updated
2021/12/16
ChemScene
Product number
CS-0677
Product name
Nelfinavir
Purity
96.90%
Packaging
50mg
Price
$280
Updated
2021/12/16
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NELFINAVIR Chemical Properties,Usage,Production

Uses

Antiviral.

Definition

ChEBI: An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.

Indications

Nelfinavir (Viracept) is probably the most commonly used protease inhibitor because of its low incidence of serious adverse effects. Its most common side effects are diarrhea and flatulence; these may resolve with continued use. In addition to the drugs contraindicated for use with all protease inhibitors, amiodarone, rifampin, and quinidine are contraindicated in patients taking nelfinavir.

brand name

Viracept (Agouron).

Antimicrobial activity

Nelfinavir inhibits HIV-1 and HIV-2 proteases. Bioavailability is affected to only a limited degree by combination with lowdose ritonavir.

Acquired resistance

Resistance is most frequently selected through a D30N mutation in the HIV protease. An L90M mutation also confers resistance.

Pharmaceutical Applications

A synthetic chemical formulated as the mesylate for oral administration.

Pharmacokinetics

Oral absorption: c. 70–80% (with food)
Cmax 750 mg thrice daily: c. 3–4 mg/L
1250 mg twice daily: c. 4 mg/L
Cmin 750 mg thrice daily: c. 1–3 mg/L
1250 mg twice daily: c. 0.7–2.2 mg/L
Plasma half-life: c. 3.5 h
Volume of distribution: c. 2–7 L/kg
Plasma protein binding: >98%
Absorption and distribution
Food improves the bioavailability and the drug should be administered with a light meal. The semen:plasma ratio is 0.07. It is distributed into breast milk.
Metabolism and excretion
One major and several minor oxidative metabolites are found in plasma. Most of an oral dose is recovered in feces as unchanged drug (22%) and metabolites (78%). The remainder is recovered in urine, mainly unchanged.
An increase in the area under the time–concentration curve (AUC) has been observed in patients with hepatic impairment, but specific dose recommendations have not been made.

Clinical Use

Treatment of HIV infection (in combination with other antiretroviral drugs)

Side effects

The most common adverse effect is diarrhea of mild to moderate severity. Other side effects include nausea, fatigue, vomiting and headache. It is associated with less dyslipidemia in comparison with ritonavir-boosted protease inhibitors.

Metabolism

Following oral administration, nelfinavir peak levels in plasma ranged from 0.34 mg/mL (10 mg/kg in the dog) to 1.7 mg/mL (50 mg/kg in the rat). In the dog, nelfinavir was slowly absorbed, and bioavailability was 47%. The drug appeared to be metabolized in the liver, and the major excretory route was in feces.

NELFINAVIR Preparation Products And Raw materials

Raw materials

Preparation Products

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NELFINAVIR Suppliers

China 68 France 1 Germany 1 India 3 South Korea 1 The Netherlands 1 United Kingdom 6 United States 20 Global 101
Chembest Research Laboratories Limited
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View Lastest Price from NELFINAVIR manufacturers

Dideu Industries Group Limited
Product
NELFINAVIR 159989-64-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nelfinavir 159989-64-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nelfinavir 159989-64-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

159989-64-7, NELFINAVIRRelated Search:

Ritonavir Nelfinavir RegeoisoMer (IMpurity D) (3S,4aS,8aS)-N-(1,1-DiMethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-Methylbenzoyl)aMino]-4-(phenylsulfonyl)butyl]-3-isoquinolinecarboxaMide Nelfinavir Related Compound A (15 mg) ((3S,4aS,8aS)-N-tert-Butyl-2-[(2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylsulfinyl)butyl]decahydroisoquinoline-3-carboxamide) Dexrazoxane Atazanavir Telithromycin NICKEL AND VANADIUM IN RESIDUAL FUEL OIL Decahydroisoquinoline Intermediate For Nelfinavir,N-Benzyloxycarbonyl-S-Phenyl-L-Cysteine *(Intermediate of Nelfinavir) NELFINAVIR MESYLATE,Nelfinavir1,Nelfinavir nesylate NELFINAVIR NELFINAVIR HYDROXY-TERT-BUTYLAMIDE NELFINAVIR-D3 Decahydro- 3 –Isoquinoline Carboxamide Mono Benzoate, Nelfinavir Mesylate, AKOS 92069 NELFINAVIR(SUBJECTTOPATENTFREE) NELFINAVIR MESYLATES

  • Nelfinavir Regeoisomer
  • N-tert-butyl-2-[2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)-oxomethyl]amino]-4-(phenylthio)butyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
  • AG 1341; AG-1341; AG1341
  • 3-isoquinolinecarboxamide,n-(1,1-dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hy
  • 8a-beta))-a-bet
  • nefinavir
  • NELFINAVIR
  • (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide
  • Nelfinavir & Nelfinavir Mesylate
  • AG 1341
  • NELFINAVIR-12
  • 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-
  • NELFINAVIR USP/EP/BP
  • (3S,4aS,8aS)-N-(tert-Butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide
  • Nelfinavir (AG-1341)
  • Nelfinavir D5
  • NELFINAVIR iMpurity
  • 159989-64-7
  • C32H45N3O4SCH4O3S
  • C32H45N3O4SC32H45N3O4SCH3SO3H
  • peptides