NORTRIPTYLINE HYDROCHLORIDE

Product Name: NORTRIPTYLINE HYDROCHLORIDE
CAS No.: 894-71-3
Chemical Name: NORTRIPTYLINE HYDROCHLORIDE
Synonyms: Vividyl;Acetexa;pamelor;Sensival;Norzepine;nortrilen;Norfenazin;aventylallegron;NORTRIPTYLINE HCL;Desitriptyline HCl
CBNumber: CB8218917
Molecular Formula: C19H22ClN
Formula Weight: 299.84
MOL File: 894-71-3.mol

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NORTRIPTYLINE HYDROCHLORIDE Property

Melting point:: 217-220?C
Flash point:: 9℃
storage temp.: 2-8°C
solubility: ethanol: 100 mg/mL
form: powder
color: white to off-white
λmax: 237nm(H2O)(lit.)
Merck: 14,6715

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 22-36/38-23/25-11-39/23/24/25-23/24/25
Safety Statements: 22-36-45-24-16-7-36/37
RIDADR: UN 1230 3/PG 2
WGK Germany: 3
RTECS: HP0175000
HS Code: 2921490002
Toxicity: LD50 oral in rat: 405mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3216
Product name: Nortriptyline Hydrochloride
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $230
Updated: 2024/03/01

Sigma-Aldrich

Product number: N-907
Product name: Nortriptyline hydrochloride solution
Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $27.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: N7261
Product name: Nortriptyline hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 10g
Price: $80.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1474005
Product name: Nortriptyline hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: N0957
Product name: Nortriptyline Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $34
Updated: 2024/03/01

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NORTRIPTYLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Aventyl,Lilly,UK,1963

Uses

Nortriptyline Hydrochloride (Amitriptyline EP Impurity C) is a tricyclic antidepressant.

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

Definition

ChEBI: Nortriptyline hydrochloride is an organic tricyclic compound. It has a role as a geroprotector.

Manufacturing Process

A mixture of 114.5 g of 5-(3-chloropropylidene)dibenzo[a,d]cyclohepta[1,4] diene, 75 ml of benzene, and about 400 ml of methylamine is heated in an autoclave at 120°C for six hours. The excess methylamine is distilled from the reaction mixture under vacuum and the residue is stirred with 300 ml of water. Acidification of the mixture with hydrochloric acid causes the separation of the hydrochloride of 5-(3-methylaminopropylidene)dibenzo[a,d] cyclohepta[1,4]diene. The product is collected by filtration and is purified by recrystallization from a mixture of absolute ethanol and ethyl acetate. MP 210°C to 212°C.

brand name

Aventyl Hydrochloride (Lilly); Aventyl Hydrochloride (Ranbaxy); Pamelor (Tyco).

Therapeutic Function

Antidepressant

General Description

Pertinent biological and chemical properties for nortriptyline,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)Nmethyl-1-propanamine hydrochloride, 5-(3-methyl-aminopropylidene)-10,11-hydro-5H-dibenzo[a,d] cycloheptene hydrochloride(Aventyl, Pamelor), are given previously in thediscussion of amitriptyline. Metabolic inactivation and eliminationare like those of amitriptyline. Nortriptyline is a selectiveNE transporter (NET) inhibitor.

Biological Activity

ki: 3.4 nm: blocks the norepinephrine transporter.ki: 161 nm: inhibits the serotonin transporter.nortriptyline, a dibenzocycloheptene-derivative tricyclic antidepressant, inhibits norepinephrine and serotonin transporters, which is used for short-term treatment of various forms of depression, including major depression, dysthymia, and atypical depressions. nortriptyline suppresses the norepinephrine presynaptic receptors, thus inhibiting the reuptake of this neurotransmitter and increasing the concentration in the synaptic cleft in the central nervous system.norepinephrine transporter is responsible for the sodium-chloride (na+/cl-) -dependent reuptake of extracellular norepinephrine. serotonin transporter transports serotonin from the synaptic cleft to the presynaptic neuron.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.

in vitro

nortriptyline dose-dependently dampened the spontaneous migration of human polymorphonuclear cells (pmn) at the highest concentrations (10-4 and 10-5 m). nortriptyline decreased the motility of the cells at 10-4m. chemotaxis of pmn triggered by 10-10m n-formyl-l-methionil-l-leucyl-l-phenylalanine (fmlp) was blocked by nortriptyline in a dose-dependent fashion [1].

in vivo

rats and mice were injected intraperitoneally with nortriptyline at the dose of 50, 25, 12.5 mg/kg. after 2 hours of the last injection, nortriptyline inducted little or no inhibition of the 4, α-dimethyl-meta-tyramine (h 77/77) induced depletion in a dose of 25 + 12.5 mg/kg. however, there was a partial blockade, evoked by nortriptyline in a dose of 50 + 25 mg/kg, of the h 77/77 elicited depletion in the noradrenaline nerve terminals in all the rats studied. additionally, nortriptyline also proved to be active in the brain, however, its activity was low [2].

References

[1]. sacerdote, p., bianchi, m., & panerai, a. chlorimipramine and nortriptyline but not fluoxetine and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro. general pharmacology: the vascular system. 1994; 25(3): 409-412.
[2]. carlsson, a., corrodi, h., fuxe, k., & hkfelt, t. effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4, α-dimethyl-meta-tyramine. european journal of pharmacology.1969; 5(4): 367-373.

NORTRIPTYLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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NORTRIPTYLINE HYDROCHLORIDE Suppliers

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View Lastest Price from NORTRIPTYLINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: NORTRIPTYLINE HYDROCHLORIDE 894-71-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-24

894-71-3, NORTRIPTYLINE HYDROCHLORIDERelated Search:

Amitriptyline trans-10-Hydroxy Nortriptyline NORTRIPTYLINE NORTRIPTYLINE HYDROCHLORIDE Amitriptyline hydrochloride 10-hydroxyamitriptyline AMITRIPTYLINE-D3 HCL (N-METHYL-D3) DIBENZOSUBEROL Cyclobenzaprine hydrochloride amitriptyline N-oxide Dibenzosuberone DIBENZOSUBERENOL 5-(3-DIMETHYLAMINOPROPYL)-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-OL AMITRIPTYLINE HCL (D6) 10,11-DIHYDRO-5 H-DIBENZO[A,D]CYCLOHEPTENE NORTRIPTYLINE-D3 HYDROCHLORIDE Piroheptine amitriptyline N-glucuronide

Nortriptyline Hydrochloride (200 mg)

Nortriptyline HCl, 1.0 mg/mL as free base

Norzepine

Sensival

Vividyl

NORTRIPTYLINE HCL(P)

Norfenazin

Nortriptyline hydrochloride solution

Nortriptyline for system suitability

1-Propanamine, 3-(10,11-dihydro-5H-dibenzoa,dcyclohepten-5-ylidene)-N-methyl-, hydrochloride

NORTRIPTYLINEHYDROCHLORIDE,USP

NORTRIPTYLINE HCL USP

Nortriptyline solution hydrochloride

3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n-methyl-1-propanamin

5-(3-(methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)dienehydrochloride

NORTRIPTYLINE HYDROCHLORIDE

NORTRIPTYLINE HCL

3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropylamine hydrochloride

3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N-methyl-1-propanamine·hydrochloride

Nortrityline Hydrochloride

(2)10,11-Dihydro-N-methyl-5H-dibenzo[A,D]cycloheptene-.delta.5.gamma.-propylamine, hydrochloride

5-[(3-(Methylamino)propylidene]-10,11-dihydro-5H-dibenzo[A,D]cycloheptene hydrochloride

5-[3-(Methylamino)propylidene]dibenzo[A,D]cyclohepta[1,5]diene hydrochloride

5H-Dibenzo[A,D]cycloheptene-.delta.(sup5),.gamma.-propylamine, 10-11-dihydro-N-methyl-, hydrochloride

5H-Dibenzo[A,D]cycloheptene-.delta.5,.gamma.-propylamine, 10,11-dihydro-N-methyl-, hydrochloride

Acetexa

Noramitriptyline hydrochloride

Amitriptyline hydrochloride impurity C

nortriptyline hydrochloride methanol*solution

Amitriptyline EP Impurity C HCl

5-(3-methylaminopropylidene)-10,11-dihydro-5h-dibenzo(a,d)cycloheptenehydroc

5h-dibenzo(a,d)cycloheptene-delta(sup5),gamma-propylamine,10-11-dihydro-n-met

aventylallegron

aventylhydrochloride

desmethylamitriptylinehydrochloride

nortrilen

pamelor

AMITRIPTYLINE HYDROCHLORIDE IMP C

3-(10, 11-DIHYDRO-5H-DIBENZO[A,D]-CYCLOHEPTEN-5-YLIDENE)-N-METHYL-1-PROPANAMINE HYDROCHLORIDE

Nortriptyline hydrochloride CRS

Nortriptyline Hydrochloride &gt

Nortriptyline for system suitability CRS

Nortriptyline HCl (Amitriptyline EP Impurity C HCl)

Amitriptyline EP Impurity C HCl (Nortriptyline HCl)

Desitriptyline HCl

ELF-101 hydrochloride

EN-7048 hydrochloride

3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine hydrochloride

10,11-Dihydro-5-(N-methyl-3-aminopropylidene)-5H-dibenzo[a,d]cycloheptene Hydrochloride

NORTRIPTYLINE HYDROCHLORIDE USP/EP/BP

NORTRIPTYLINE HCL(USP)(COMING SOON)(P) USP/EP/BP

Nortriptyline HydrochlorideQ: What is Nortriptyline Hydrochloride Q: What is the CAS Number of Nortriptyline Hydrochloride Q: What is the storage condition of Nortriptyline Hydrochloride Q: What are the applications of Nortriptyline Hydrochloride

Amitriptyline Impurity 3

Nortriptyline Hydrochloride (1474005)

N-Desmethyl Amitriptyline HCl

Amitriptyline Hydrochloride EP Impurity C as Hydrochloride

Amitriptyline Hydrochloride Impurity C as Hydrochloride

Nortriptyline hydrochloride in methanol