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2,4-Difluorobenzyl bromide

Product Name
2,4-Difluorobenzyl bromide
CAS No.
23915-07-3
Chemical Name
2,4-Difluorobenzyl bromide
Synonyms
1-(bromomethyl)-2,4-difluorobenzene;TIMTEC-BB SBB006567;2,4-Difluorobenzyl b;4-Difluorobenzyl broMide;2,4-DIFLUOROBENZYL BROMID;2,4-DIFLUOROBENZYL BROMIDE;2,4-Difluoro Bromine Benzyl;à-bromo-2,4-difluorotoluene;α-bromo-2,4-difluorotoluene;a-Bromo-2,4-difluorotoluene
CBNumber
CB8220095
Molecular Formula
C7H5BrF2
Formula Weight
207.02
MOL File
23915-07-3.mol
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2,4-Difluorobenzyl bromide Property

Melting point:
18 °C
Boiling point:
28 °C
Density 
1.613 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.525(lit.)
Flash point:
104 °F
storage temp. 
Inert atmosphere,2-8°C
form 
Liquid
Specific Gravity
1.63
color 
Clear yellow
Sensitive 
Lachrymatory
BRN 
4177539
CAS DataBase Reference
23915-07-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C,F
Risk Statements 
10-34-42/43-36
Safety Statements 
23-26-36/37/39-45-25-16
RIDADR 
UN 2920 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive/Lachrymatory
HazardClass 
8
PackingGroup 
III
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
264415
Product name
2,4-Difluorobenzyl bromide
Purity
98%
Packaging
5g
Price
$46.5
Updated
2023/01/07
Sigma-Aldrich
Product number
264415
Product name
2,4-Difluorobenzyl bromide
Purity
98%
Packaging
25g
Price
$125
Updated
2023/01/07
TCI Chemical
Product number
B1710
Product name
2,4-Difluorobenzyl Bromide
Purity
>98.0%(GC)
Packaging
5g
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
B1710
Product name
2,4-Difluorobenzyl Bromide
Purity
>98.0%(GC)
Packaging
25g
Price
$222
Updated
2025/07/31
TRC
Product number
D447555
Product name
2,4-Difluorobenzyl bromide
Packaging
10g
Price
$165
Updated
2021/12/16
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2,4-Difluorobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

2,4-Difluorobenzyl bromide has been used in the preparation of:

  • novel 1,2,4-triazolium derivatives
  • 1,5-biaryl pyrrole EP1 receptor antagonists

Synthesis

56456-47-4

23915-07-3

The general procedure for the synthesis of 2,4-difluorobenzyl bromide from 2,4-difluorobenzyl alcohol was as follows: to a solution of diethyl ether (10 mL) of 2,4-difluorobenzyl alcohol (450 mg, 3.12 mmol) was slowly added phosphorus tribromide (0.2 mL, 2.18 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction (monitored by thin layer chromatography), the reaction was quenched with ice water (20 mL) and extracted with ethyl acetate (2 x 20 mL). The organic layers were combined, washed sequentially with water (40 mL) and saturated saline (40 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the crude product. Purification by silica gel column chromatography with 5% ethyl acetate/hexane as eluent gave 2,4-difluorobenzyl bromide (420 mg, 2.02 mmol, 65% yield) as a colorless liquid.1H NMR (200 MHz, CDCl3): δ 7.43-7.31 (m, 1H), 6.92-6.77 (m, 2H), 4.48 (s, 2H).

References

[1] Patent: US2012/329788, 2012, A1. Location in patent: Page/Page column 26

2,4-Difluorobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Difluorobenzyl bromide Suppliers

Americas 1 Belgium 1 China 225 Europe 3 France 1 Germany 3 India 9 Italy 1 Japan 3 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 19 United States 37 Global 307
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 2,4-Difluorobenzyl bromide manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2,4-Difluorobenzyl bromide 23915-07-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-06
Henan Fengda Chemical Co., Ltd
Product
2,4-Difluorobenzyl bromide 23915-07-3
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Career Henan Chemical Co
Product
2,4-Difluorobenzyl bromide 23915-07-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-06-25

23915-07-3, 2,4-Difluorobenzyl bromideRelated Search:

Benzyltriethylammonium chloride Decabromodiphenyl Ethane Dibenzyl disulfide Ethyl bromodifluoroacetate Rocuronium bromide 1,2-Difluorobenzene Allyl bromide Sodium bromate Bromofluoromethane Benzyl bromide Ethidium bromide Dibenzylideneacetone alpha-Chloro-o-fluorotoluene BENDROFLUMETHIAZIDE Benzyl chloride 4-CHLORO-2-TRICHLOROMETHYL-QUINOLINE Methyl bromide 2,3-Difluorobenzyl bromide 98%,2,3-DIFLUOROBENZYL BROMIDE

  • 4-Difluorobenzyl broMide
  • alpha-BroMo-2,4-difluorotoluene, 98% 5GR
  • ALPHA-BROMO-2,4-DIFLUOROTOLUENE
  • Toluene, α-broMo-2,4-difluoro- (8CI)
  • 1-(Bromomethyl)-2,4-difluorobenzene, alpha-Bromo-2,4-difluorotoluene
  • 2,4-Difluorobenzyl broMide 98%, 4-Difluorobenzyl broMide 98%
  • 2,4-DIFLUOROBENZYL BROMIDE
  • 2,4-Difluoro Bromine Benzyl
  • TIMTEC-BB SBB006567
  • 1-(bromomethyl)-2,4-difluorobenzene
  • 2,4-DIFLUOROBENZYL BROMID
  • Benzene, 1-(bromomethyl)-2,4-difluoro-
  • à-bromo-2,4-difluorotoluene
  • α-bromo-2,4-difluorotoluene
  • a-Bromo-2,4-difluorotoluene
  • 2,4-Difluorobenzylbromide,98%
  • alpha-Bromo-2,4-difluorotoluene,98%
  • 2,4-Difluorobenzyl bromide,α-Bromo-2,4-difluorotoluene
  • 2,4-Difluorobenzyl b
  • 2,4-Difluorobenzyl Bromide &gt
  • 2,4-Difluorobenzyl bromide ISO 9001：2015 REACH
  • 23915-07-3
  • BENZYL HALIDE
  • Aryl
  • C7
  • Building Blocks
  • Halogenated Hydrocarbons
  • Organic Building Blocks
  • Aromatic Halides (substituted)
  • Benzene series
  • Miscellaneous
  • Fluorinated benzene series
  • Fluoro-contained benzyl bromide series
  • Fluorine series