2-Quinoxalinecarboxylic acid methyl ester

Product Name: 2-Quinoxalinecarboxylic acid methyl ester
CAS No.: 1865-11-8
Chemical Name: 2-Quinoxalinecarboxylic acid methyl ester
Synonyms: QCA-Methyl ester;Methyl quinoxaline-2-carboxylate;Methyl quinoxaline-2-carboxylate 98%;-Quinoxalinecarboxylic acid Methyl ester;2-Quinoxalinecarboxylic acid methyl ester
CBNumber: CB82217152
Molecular Formula: C10H8N2O2
Formula Weight: 188.18
MOL File: 1865-11-8.mol

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2-Quinoxalinecarboxylic acid methyl ester Property

Melting point:: 110-110.5 °C
Boiling point:: 302.8±22.0 °C(Predicted)
Density: 1.272±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Sparingly)
form: Solid
pka: 0.22±0.30(Predicted)
color: Brown to Dark Brown

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Safety

HS Code: 2933992000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: Q765270
Product name: 2-QuinoxalinecarboxylicAcidMethylEster
Packaging: 250mg
Price: $150
Updated: 2021/12/16

TRC

Product number: Q765270
Product name: 2-QuinoxalinecarboxylicAcidMethylEster
Packaging: 2.5g
Price: $1190
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 61532
Product name: 2-QuinoxalinecarboxylicAcidMethylEster
Packaging: 2.5g
Price: $2200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1046604
Product name: 2-QUINOXALINE CARBOXYLIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $503.25
Updated: 2021/12/16

Matrix Scientific

Product number: 059244
Product name: Quinoxaline-2-carboxylic acid methyl ester
Purity: 95+%
Packaging: 1g
Price: $549
Updated: 2021/12/16

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2-Quinoxalinecarboxylic acid methyl ester Chemical Properties,Usage,Production

Uses

2-Quinoxalinecarboxylic Acid Methyl Ester has been used as a reactant in the synthesis of quinoxaline derivatives that show antimycobacterial activity, while displaying minor activity itself. In addition to having the substructure that exhibits antitumor activity, it is also used in the design of guanine-guanine selective DNA cleaving agents.

Synthesis

67-56-1

879-65-2

1865-11-8

2-Quinoxaline carboxylic acid (1.0 g, 5.7 mmol, 1.0 eq.) was dissolved in 20 mL of methanol and thionyl chloride (1.25 mL, 17.2 mmol, 3.0 eq.) was added slowly. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The residue was extracted with ethyl acetate, washed with water, partitioned and the organic phase was dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure. Purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=5:1) afforded the light yellow solid product methyl quinoxaline-2-carboxylate (1.01 g, yield 93.5%).

References

[1] Advanced Synthesis and Catalysis, 2009, vol. 351, # 16, p. 2549 - 2552
[2] Patent: CN107383024, 2017, A. Location in patent: Paragraph 0395
[3] Patent: WO2018/116072, 2018, A1. Location in patent: Page/Page column 74
[4] Supramolecular Chemistry, 2015, vol. 27, # 11-12, p. 780 - 786
[5] Tetrahedron, 2016, vol. 72, # 10, p. 1375 - 1380

2-Quinoxalinecarboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Quinoxalinecarboxylic acid methyl ester Suppliers

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1865-11-8, 2-Quinoxalinecarboxylic acid methyl esterRelated Search:

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1865-11-8