2-Quinoxalinecarboxylic acid methyl ester
- Product Name
- 2-Quinoxalinecarboxylic acid methyl ester
- CAS No.
- 1865-11-8
- Chemical Name
- 2-Quinoxalinecarboxylic acid methyl ester
- Synonyms
- QCA-Methyl ester;Methyl quinoxaline-2-carboxylate;Methyl quinoxaline-2-carboxylate 98%;-Quinoxalinecarboxylic acid Methyl ester;2-Quinoxalinecarboxylic acid methyl ester
- CBNumber
- CB82217152
- Molecular Formula
- C10H8N2O2
- Formula Weight
- 188.18
- MOL File
- 1865-11-8.mol
2-Quinoxalinecarboxylic acid methyl ester Property
- Melting point:
- 110-110.5 °C
- Boiling point:
- 302.8±22.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Sparingly)
- form
- Solid
- pka
- 0.22±0.30(Predicted)
- color
- Brown to Dark Brown
Safety
- HS Code
- 2933992000
N-Bromosuccinimide Price
- Product number
- Q765270
- Product name
- 2-QuinoxalinecarboxylicAcidMethylEster
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- Q765270
- Product name
- 2-QuinoxalinecarboxylicAcidMethylEster
- Packaging
- 2.5g
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- 61532
- Product name
- 2-QuinoxalinecarboxylicAcidMethylEster
- Packaging
- 2.5g
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- CHM1046604
- Product name
- 2-QUINOXALINE CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.25
- Updated
- 2021/12/16
- Product number
- 059244
- Product name
- Quinoxaline-2-carboxylic acid methyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $549
- Updated
- 2021/12/16
2-Quinoxalinecarboxylic acid methyl ester Chemical Properties,Usage,Production
Uses
2-Quinoxalinecarboxylic Acid Methyl Ester has been used as a reactant in the synthesis of quinoxaline derivatives that show antimycobacterial activity, while displaying minor activity itself. In addition to having the substructure that exhibits antitumor activity, it is also used in the design of guanine-guanine selective DNA cleaving agents.
Synthesis
67-56-1
879-65-2
1865-11-8
2-Quinoxaline carboxylic acid (1.0 g, 5.7 mmol, 1.0 eq.) was dissolved in 20 mL of methanol and thionyl chloride (1.25 mL, 17.2 mmol, 3.0 eq.) was added slowly. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The residue was extracted with ethyl acetate, washed with water, partitioned and the organic phase was dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure. Purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=5:1) afforded the light yellow solid product methyl quinoxaline-2-carboxylate (1.01 g, yield 93.5%).
References
[1] Advanced Synthesis and Catalysis, 2009, vol. 351, # 16, p. 2549 - 2552
[2] Patent: CN107383024, 2017, A. Location in patent: Paragraph 0395
[3] Patent: WO2018/116072, 2018, A1. Location in patent: Page/Page column 74
[4] Supramolecular Chemistry, 2015, vol. 27, # 11-12, p. 780 - 786
[5] Tetrahedron, 2016, vol. 72, # 10, p. 1375 - 1380
2-Quinoxalinecarboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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