Neochinulin A

Product Name: Neochinulin A
CAS No.: 51551-29-2
Chemical Name: Neochinulin A
Synonyms: Neochinulin A;Neoechinulin A;(S,Z)-3-Methyl-6-((2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl)methylene)piperazine-2,5-dione;(3S,6Z)-3-Methyl-6-{[2-(2-methyl-3-buten-2-yl)-1H-indol-3-yl]methylene}-2,5-piperazinedione;(6S)-3-[(Z)-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]methylene]-6-methyl-2,5-piperazinedione;2,5-Piperazinedione, 3-[[2-(1,1-dimethyl-2-propen-1-yl)-1H-indol-3-yl]methylene]-6-methyl-, (3Z,6S)-;(3S)-3α-Methyl-6-[(Z)-[2-(1,1-dimethyl-2-propenyl)-1H-indole-3-yl]methylene]hexahydropyrazine-2,5-dione
CBNumber: CB82224457
Molecular Formula: C19H21N3O2
Formula Weight: 323.39
MOL File: 51551-29-2.mol

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Neochinulin A Property

Melting point:: 272-275 °C
Boiling point:: 655.7±55.0 °C(Predicted)
Density: 1+-.0.06 g/cm3(Predicted)
storage temp.: 4°C, away from moisture and light
pka: 11.96±0.40(Predicted)
form: Solid
color: White to off-white

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0019376
Product name: NEOECHINULIN A
Purity: 95.00%
Packaging: 5MG
Price: $502.51
Updated: 2021/12/16

CSNpharm

Product number: CSN14542
Product name: NeoechinulinA
Packaging: 1mg
Price: $370
Updated: 2021/12/16

Arctom

Product number: AS314334
Product name: NeoechinulinA
Packaging: 5mg
Price: $371
Updated: 2021/12/16

Arctom

Product number: CFN98823
Product name: NeoechinulinA
Packaging: 5mg
Price: $513
Updated: 2021/12/16

Crysdot

Product number: CD32001160
Product name: NeoechinulinA
Purity: 95+%
Packaging: 5mg
Price: $810
Updated: 2021/12/16

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Neochinulin A Chemical Properties,Usage,Production

Uses

Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice[1][2].

in vivo

In the Y-maze test, the intracerebroventicular (i.c.v.) administration of LPS (10 μg/mouse) significantly decreased spontaneous alternation behavior, which was prevented by the prior administration of neoechinulin A (300ng/mouse, i.c.v.)^[1].

References

[1] Humbert M, et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010;5(3):e9430. Published 2010 Mar 4. DOI:10.1371/journal.pone.0009430
[2] Kim KS, et al. Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-кB and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules. 2013;18(11):13245-13259. Publish DOI:10.3390/molecules181113245
[3] Dewapriya P, et al. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. Neurotoxicology. 2013;35:30-40. DOI:10.1016/j.neuro.2012.12.004

Neochinulin A Preparation Products And Raw materials

Raw materials

Preparation Products

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Neochinulin A Suppliers

China 49 United States 6 Global 55

Nanjing Chemlin Chemical Co., Ltd

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Wuhan ChemFaces Biochemical Co., Ltd.

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EMMX Biotechnology LLC

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Shanghai Haozhixiang Biotechnology Co., Ltd

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai ChengShao Biological Technology Co., Ltd.

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51551-29-2, Neochinulin ARelated Search:

beta-Eudesmol hydroxygenkwanin 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Artemether (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one beta-Sitosterol alpha-Cyperone Hydroxyecdysone MOSLOFLAVONE alpha-Terpineol

(3S)-3α-Methyl-6-[(Z)-[2-(1,1-dimethyl-2-propenyl)-1H-indole-3-yl]methylene]hexahydropyrazine-2,5-dione

(6S)-3-[(Z)-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]methylene]-6-methyl-2,5-piperazinedione

Neochinulin A

Neoechinulin A

2,5-Piperazinedione, 3-[[2-(1,1-dimethyl-2-propen-1-yl)-1H-indol-3-yl]methylene]-6-methyl-, (3Z,6S)-

(3S,6Z)-3-Methyl-6-{[2-(2-methyl-3-buten-2-yl)-1H-indol-3-yl]methylene}-2,5-piperazinedione

(S,Z)-3-Methyl-6-((2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl)methylene)piperazine-2,5-dione

51551-29-2