Sitafloxacin

ChemicalBook > CAS DataBase List > Sitafloxacin

Description References

Product Name: Sitafloxacin
CAS No.: 127254-12-0
Chemical Name: Sitafloxacin
Synonyms: spifloxacin;Sitfloxacfn;Sitafloxacfn;The west was;Sitafloxacin-d4;Sitafloxacin anhydrous;Sitafloxacin (DU-6859a);Sitafloxacin ABCDEFGHJKL;7-((S)-7-Amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4;7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylicaci
CBNumber: CB8222468
Molecular Formula: C19H18ClF2N3O3
Formula Weight: 409.81
MOL File: 127254-12-0.mol

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Sitafloxacin Property

Boiling point:: 629.2±55.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: slightly soluble; DMSO: slightly soluble; Methanol: slightly soluble
form: A crystalline solid
pka: 6.39±0.50(Predicted)
CAS DataBase Reference: 127254-12-0(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0006381
Product name: SITAFLOXACIN
Purity: 95.00%
Packaging: 1G
Price: $3405.15
Updated: 2021/12/16

Matrix Scientific

Product number: 120731
Product name: 7-((S)-7-Amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid
Purity: 97%
Packaging: 1g
Price: $3960
Updated: 2021/12/16

Matrix Scientific

Product number: 120731
Product name: 7-((S)-7-Amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylicacid
Purity: 97%
Packaging: 5g
Price: $11880
Updated: 2021/12/16

Crysdot

Product number: CD31004021
Product name: Sitafloxacin
Purity: 98+%
Packaging: 5mg
Price: $88
Updated: 2021/12/16

Crysdot

Product number: CD31004021
Product name: Sitafloxacin
Purity: 98+%
Packaging: 10mg
Price: $166
Updated: 2021/12/16

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Sitafloxacin Chemical Properties,Usage,Production

Description

Sitafloxacin (Trade name: Gracevit in Japan) belongs to a new generation, broad-spectrum oral fluoroquinolone antibiotics. It is highly active against various kinds of gram-negative, gram-positive and anaerobic clinical isolates, even including strains that are resistant to other kinds of fluoroquinolone antibiotics. It has been listed in Japan for the treatment of respiratory and urinary tract infections. It also shows potential for the treatment of Buruli ulcer. Its mechanism of action is through inhibiting the Topoisomerase II ligase domain of bacteria, causing DNA fragmentation to inhibit the DNA synthesis of bacteria.

References

http://www.biochempartner.com/product_details.aspx?item_id=6084
https://en.wikipedia.org/wiki/Sitafloxacin

Description

Sitafloxacin hydrate is the newest member (fourth generation) of the fluoroquinolone family of antibiotics that exhibits broad spectrum activity against many Gram-positive, Gramnegative, and anaerobic clinical isolates, including strains resistant to other fluoroquinolones. Since the launch of the first fluoroquinolone norfloxacin (patented in 1978), 20 other versions have made it to market with ciprofloxacin and levofloxacin experiencing the most prevalent usage. The mechanism of action involves inhibition of bacterial type II topoisomerases, both DNA gyrase and topoisomerase IV. By inhibiting these enzymes and preventing DNA supercoiling, cell division is disrupted leading to cell death. In Gram-negative bacteria, the primary target appears to be gyrase, whereas topoisomerase IV is involved in Gram-positive bacteria. Dual inhibition is attractive for widespread activity and avoidance of resistance as both encoding genes would have to acquire mutations.

Originator

Daiichi Sankyo (Japan)

Uses

Antibacterial (DNA-gyrase inhibitor).

Definition

ChEBI: Sitafloxacin is a member of quinolines, a quinolone antibiotic and a fluoroquinolone antibiotic.

brand name

Gracevit

Pharmaceutical Applications

A group 4 quinolone formulated for oral or intravenous use. In-vitro activity is similar to or better than that of moxifloxacin. The antibacterial spectrum covers Gram-positive and Gram-negative bacteria including anaerobes. It has a chlorine atom at the C-8 position, and therefore has potential for phototoxicity. Early interest in this compound has not been maintained, but it is available in Japan.

Side effects

As a class, the major adverse events for fluoroquinolones are cardiac arrhythmia (due to QT interval 622 Shridhar Hegde and Michelle Schmidt prolongation), major phototoxicity, CNS disturbances (seizures, dizziness, and headaches), and tendonitis. The GI side effects, common to most antimicrobials, include Clostridium difficile-associated diarrhea (CDAD) and alterations in glucose homeostasis. From the clinical safety profile of sitafloxacin (1,059 patients receiving either 50 mg b.i.d. or 100 mg b.i.d.), about a third of patients experienced an adverse event with the most common being diarrhea, liver enzyme elevations, and headaches; however, the risk of QT prolongation, hypoglycemia, and hepatotoxicity were all considered to be low. Phototoxicity appears to be the limiting toxicity, particularly in non-Asian patients.

Sitafloxacin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sitafloxacin manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Sitafloxacin 127254-12-0
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Months
Release date: 2022-11-20

Dideu Industries Group Limited

Product: Sitafloxacin 127254-12-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: Sitafloxacin 127254-12-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

127254-12-0, SitafloxacinRelated Search:

Ofloxacin Ciprofloxacin Lithium diisopropylamide Norfloxacin Glycine Moxifloxacin Sodium 1-heptanesulfonate 1-AdaMantanethylaMine ISOHEPTANE Levofloxacin 6-Aminocaproic acid Heptane ALTRENOGEST Gatifloxacin Sitafloxacin Sesquihydrate (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE 3-Quinolinecarboxylic acid, 7-[(7S)-7-aMino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-, hydrate Sitafloxacin Impurity 2

spifloxacin

7-[(4S)-4-Amino-6-azaspiro[2.4]heptan-6-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid

3-Quinolinecarboxylic acid, 7-[(7S)-7-aMino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-

Sitafloxacin anhydrous

7-((S)-7-Amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4

Sitafloxacfn

Sitfloxacfn

Sitafloxacin-d4

Sitafloxacin ABCDEFGHJKL

7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid

Sitafloxacin (DU-6859a)

7-((S)-7-Amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

The west was

7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylicaci

127254-12-0

C19H18ClF2N3O3

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