2,3-Di-O-para-toluoyl-D-tartaric acid

Product Name: 2,3-Di-O-para-toluoyl-D-tartaric acid
CAS No.: 32634-68-7
Chemical Name: 2,3-Di-O-para-toluoyl-D-tartaric acid
Synonyms: D-DTTA;DI-P-TOLUOYL-D-TARTARIC ACID;D-PTTA;RivastigMine Related CoMpound A;(+)-DTTA;2,3-Di-O-para-toluoy;Letomovir impurity D;RivastigMine USP RC A;toluoyl-tartaric acid;Citalopram Impurity 43
CBNumber: CB8225287
Molecular Formula: C20H18O8
Formula Weight: 386.35
MOL File: 32634-68-7.mol

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2,3-Di-O-para-toluoyl-D-tartaric acid Property

Melting point:: 169-171 °C(lit.)
alpha: 136 º (c=1, EtOH)
Boiling point:: 432.57°C (rough estimate)
Density: 1.3084 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 139 ° (C=1, EtOH)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Ethanol (Sparingly), Methanol (Slightly)
form: Solid
pka: 1.46±0.25(Predicted)
color: White to Off-White
optical activity: [α]19/D +138°, c = 1 in ethanol
Water Solubility: 112.55mg/L at 25℃
BRN: 3225584
LogP: 2.97 at 25℃
CAS DataBase Reference: 32634-68-7(CAS DataBase Reference)
NIST Chemistry Reference: (+)-Di-o-4-toluoyl-d-tartaric acid(32634-68-7)
EPA Substance Registry System: Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)- (32634-68-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36/37-26
WGK Germany: 3
F: 3-10
TSCA: T
HS Code: 29181300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 302813
Product name: (+)-O,O′-Di-p-toluoyl-D-tartaric acid
Purity: made from synthetic tartaric acid, 97%
Packaging: 25g
Price: $118.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1604869
Product name: Rivastigmine Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $1200
Updated: 2025/07/31

TCI Chemical

Product number: D1417
Product name: (+)-Di-p-toluoyl-D-tartaric Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: D1417
Product name: (+)-Di-p-toluoyl-D-tartaric Acid
Purity: >98.0%(HPLC)(T)
Packaging: 250g
Price: $141
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR2029
Product name: Rivastigmine Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 30mg
Price: $425.6
Updated: 2025/07/31

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2,3-Di-O-para-toluoyl-D-tartaric acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

blood volume expander

Uses

Inhibitor of enzyme. Rivastigmine USP Related Compound A.

Flammability and Explosibility

Not classified

Synthesis

72842-25-2

32634-68-7

General procedure for the synthesis of D-(+)-di-p-toluoyltartaric acid from L-(-)-p-toluoyltartaric anhydride: 150 g of D-tartaric acid and 200 mL of toluene were added to a 1000 mL three-necked flask, and 1.5 g of copper sulfate was added as a catalyst under stirring conditions. 330 g of methylbenzoyl chloride was slowly added dropwise for a controlled period of 3 hours. After the dropwise addition, the reaction was continued for 6 hours. Upon completion of the reaction, the mixture was transferred to a centrifuge for separation. Next, 495.4 g of DP-methyldibenzoyltartaric anhydride, appropriate amount of water and toluene were added to a 2000 mL three-necked flask, heated to reflux and kept for 5 hours. At the end of the reaction, it was cooled to room temperature and 374.4 g of DP-methyldibenzoyltartaric acid was isolated. The product was used for TEM test and its structure is shown in Figure 1. The purity of the finished product D-p-methyldibenzoyltartaric acid was determined to be 99.61% with an overall yield of 96.6%.

References

[1] Patent: CN104447338, 2016, B. Location in patent: Paragraph 0034-0036

2,3-Di-O-para-toluoyl-D-tartaric acid Preparation Products And Raw materials

Raw materials

Preparation Products

CARUMONAM

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View Lastest Price from 2,3-Di-O-para-toluoyl-D-tartaric acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (+)-Di-p-toluoyl-D-tartaric acid 32634-68-7
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 10000kg
Release date: 2021-11-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,3-Di-O-para-toluoyl-D-tartaric acid 32634-68-7
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Henan Aochuang Chemical Co.,Ltd.

Product: 2,3-Di-O-para-toluoyl-D-tartaric acid 32634-68-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

32634-68-7, 2,3-Di-O-para-toluoyl-D-tartaric acidRelated Search:

(-)-Di-p-toluoyl-L-tartaric acid Di-p-toluoyl-D-tartaric acid monohydrate DL-Malic acid (+)-Dibenzoyl-D-tartaric acid monohydrate Di-p-anisoyl-L-tartaric acid (-)-Dibenzoyl-L-tartaric acid monohydrate Dibenzoyl-L-tartaric acid (+)-Dibenzoyl-D-tartaric acid Dibenzoyltartaric acid tert-Butanesulfinamide D-Tartaric acid 2,3-Di-O-para-toluoyl-D-tartaric acid 4-[(1S)-(4-Dimethylamino)-1-(4-fluotophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile (2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid (+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT R-VENLAFAXINE-DI-P-TOLUOYL-D-TARTRATE SALT

RivastigMine USP RC A

RivastigMine Related CoMpound A

D- twoMethylbenzoyltartaric acid

(+)-2,3-Di-p-toluoyl-D-tartaric acid

(+)-Di-<i>p-</i>toluoyl-D-tartaric acid

D - 2 Methyl benzoyl tartaric acid

(+)-Di-1,4-toluoyl-D-tartaric acid [S(R*,R*)]-2,3-bis[(4-methylbenzoyl)oxy]succinic acid

(+)- Ditoluoyltartaric acid

(2S,3S)-(+)-di-O-(p-toluoyl)-tartaric acid

Di-p-toluoyl-D-tartaric Acid,99%e.e.

(2S,3S)-(+)-Di-O-4-toluoyl-D-tartaric acid for synthesis

(-)-di-p-Toluyl-L-tartaric acid

D-DTTA

DI-(4-METHYL)BENZOYL-D-TARTARIC ACID

(+)-DTTA

D-(+)-TARTARIC ACID-O,O'-DI-P-TOLUOYL ESTER

D-(+)-TARTARIC ACID DI-4-TOLUOYL ESTER

D-PTTA

DI-P-TOLUOYL-D-TARTARIC ACID

(+)-DI-P-TOLUOYL-D-TRATARIC ACID

DI-O-4-TOLUOYL-D-TARTARIC ACID

(+)-DI-O,O'-P-TOLUYL-D-TARTARIC ACID

[s(r*,r*)]-2,3-bis[(4-methylbenzoyl)oxy]succinic acid

O,O'-DI-TOLUOYL-D-(+)-TARTARIC ACID

(+)-O,O'-DI-P-TOLUOYL-D-TARTARIC ACID

O,O'-DI-P-TOLUOYL-D-TARTARIC ACID

Di-p-Toluoyl-D-Tartaric Acid Anhydrate

Di-4-Toluoyl-D-tartaric acid

DI-P-TOLUOYL-D-TARTARIC ACID, 97%, MADE FROM UNNATURAL TARTARIC ACID

DI-P-Toluoyl-D-Tartaric Acid Anhydrous

Di-Para-Toluoyl-D-TartaricAcid

Di-Para-Toluoyl-L-TartaricAcid,Anhydrous

(+)-DI-P-TOLUOYL-D-TARTARIC ACID D-(+)-DTTA 99%

Di-p-Toluoyl-D-tartaric

DI-P-TOLUOYL-D-TARTARIC ACID\ S-(-)-TERT-BUTANESULFINAMIDE

(+)-DI-O,O''-P-TOLUYL-D-WEINSURE

(+)-Di-p-toluyl-D-tartaric acid

toluoyl-tartaric acid

DI-P-TOTUOYL-D-TARTARIC ACID

3-hydroxy-2-[(2-methylphenyl)-oxomethoxy]-2-[(2-methylphenyl)-oxomethyl]butanedioic acid

(-)-Nicotine (+)-O,O&rsquo

(+)-Di-1,4-toluoyl-D-tartaric acid(DDTTA)

(S,S)-O,O'-Di-p-toluoyltartaric acid

p-Toluic acid, diester with D-tartaric acid (7CI)

Tartaric acid, di-p-toluate, (+)- (8CI)

Rivastigmine Related Compound A (15 mg) ((+)-Di-p-toluoyl-D-(+)-tartaric acid)

(2S,35)-(-)-di-o-4-Toluoyl-D-tartaric acid

2,3-bis[(4-methylbenzoyl)oxy]-,[s-(theta,theta)]-butanedioicaci

2,3-Bis[(4-methylbenzoyl)oxy]succinic acid

2,3-DI-O-PARA-TOLUOYL-D-TARTARICACIDHYDRATE

Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, [S-(R*,R*)]-

L-di-p-Toluyltartaric acid

2,3-Di-O-para-toluoyl-D-tartaric acid

(2S,3S)-2,3-BIS-(4-METHYL-BENZOYLOXY)-SUCCINIC ACID

(2S,3S)-(+)-DI-O-4-TOLUOYL-TARTARIC ACID

D-(+)-DI-P-TOLUOYL TARTARIC ACID

(+)-O,O'-Di-1,4-toluoyl-D-tartaric acid

L-(-)-DI-P-TOLUOYL-D-TARTARIC ACID