ChemicalBook > CAS DataBase List > Indigo Carmine

Indigo Carmine

Product Name
Indigo Carmine
CAS No.
860-22-0
Chemical Name
Indigo Carmine
Synonyms
E132;73015;Was35;l-blau2;murabba;1311blue;Greell S;CI 73015;C Blue 2;acidbluew
CBNumber
CB8231484
Molecular Formula
C16H11N2NaO8S2
Formula Weight
446.38
MOL File
860-22-0.mol
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Indigo Carmine Property

Melting point:
>300°C
Density 
1.01 g/mL at 20 °C
refractive index 
n20/D 1.335
storage temp. 
room temp
solubility 
1g/l
form 
Powder/Solid
Colour Index 
73015
color 
Very dark blue to purple
Odor
Light odour
PH
7 (10g/l, H2O, 20℃)
PH Range
11.5(blue)-14.0(yellow)
Water Solubility 
1 g/100 mL (25 ºC)
λmax
608nm
Sensitive 
Light Sensitive
Merck 
14,4944
BRN 
4103904
Stability:
Stable. Incompatible with strong oxidizing agents.
Biological Applications
Detecting microorganisms; treating amyloidosis,testicular cancer; medical devices; drug delivery system
Major Application
Display device, sensor, chemical-mechanical polishing, batteries, photographic materials, thermoplastics, inks, highlighters, detergents, disinfectants, rodenticide, colored bubbles, hair dyes, cosmetics, food, determine bacterial growth, antiischemic Magents, antiseptic, antitumor agents, Alzheimer’s disease, psychoactive drugs, Tooth whitening
CAS DataBase Reference
860-22-0(CAS DataBase Reference)
EPA Substance Registry System
C.I. Acid Blue 74 (860-22-0)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
RTECS 
DU3000000
TSCA 
Yes
HS Code 
32041200
Hazardous Substances Data
860-22-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
131164
Product name
Indigo carmine
Purity
certified by the Biological Stain Commission, Dye content 85%
Packaging
25g
Price
$47.5
Updated
2021/03/22
Sigma-Aldrich
Product number
57000
Product name
Indigo carmine
Purity
for microscopy (Bact., Hist.), indicator (pH 11.5-14.0)
Packaging
25 g
Price
$53.7
Updated
2021/03/22
Sigma-Aldrich
Product number
1.04724
Product name
Indigo carmine (C.I. 73015)
Purity
for analysis
Packaging
25 g
Price
$58
Updated
2021/03/22
Sigma-Aldrich
Product number
57000
Product name
Indigo carmine
Purity
for microscopy (Bact., Hist.), indicator (pH 11.5-14.0)
Packaging
100 g
Price
$167
Updated
2021/03/22
Sigma-Aldrich
Product number
131164
Product name
Indigo carmine
Purity
certified by the Biological Stain Commission, Dye content 85%
Packaging
100g
Price
$152
Updated
2021/03/22
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Indigo Carmine Chemical Properties,Usage,Production

Description

Indigo carmine is indigotindisulfonate sodium, a marker dye used during cystoscopy and ureteral catheterization.
(1) Indigo carmine is also used in endoscopic procedures, lymph node and vessel delineation, and for tumor localization. Indigo carmine is an unapproved drug without FDA approved labeling.
(2) There is no single dye that can replace indigo carmine. Choice of alternative agent will depend on type of procedure and physician discretion, as well as product availability.
Indigo Carmine (IC) is the most common chemical dye for clothes dyeing, which is considered as a refractory molecule since it is required a rather strong chemical treatment for its elimination from the water waste. The presence of this dye in residuals causes notorious change of water color and smell even in very low concentration. Moreover, if some of this water reaches natural streams it can be toxic for aquatic living entities due to the formation of toxic compounds such as aromatic amines.

Chemical Properties

purple powder

Chemical Properties

FD & C Blue No. 2 is principally the disodium salt of 2-( 1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro3-oxo-lH-indole-5-sulfonic acid.
The colorant is a blue-brown to red-brown powder that dissolves in water to give a solution that is blue at neutrality, blue-violet in acid, and green to yellow-green in base. When dissolved in concentrated sulfuric acid, it yields a blue-violet solution that turns blue when diluted with water. It is soluble in 95% ethanol.
FD & C Blue No. 2 is used in dessert powders, bakery goods, cereals, snack foods, confectionery products, maraschino cherries, sausage, ice cream, sherbet, and dairy products. The color is also used in drug preparations.1 .

Uses

Colorant for nylon, surgical sutures, foods and ingested drugs. As a reagent for functional kidney tests, for detection of nitrates, chlorates and in testing milk.

Uses

Indigo Carmine (FD&C Blue #2) is a colorant. It has poor ph stability in that after 1 week at ph 3 and 5 it will appreciably fade, at ph 7 considerably fade, and at ph 8 fade completely. It is the least soluble of all food colors, with a solubility of 1.6 g in 100 ml of water at 25°c. Complete fading occurs in alkalis such as 10% sodium carbonate and 10% sodium hydroxide, with fading also occurring in 10% sugar systems. It has very poor light stability and oxidation stability, and moderate stability to heat; it has a deep blue hue with poor tinctorial strength. It is the only food color that has good resistance to reducing agents, but has very poor compatibility with food components. The major use is in pet food, but it is also used in candies, confections, and baked goods. The common name is indigotine.

Uses

5,5’Indigodisulfonic Acid Disodium Salt is a food additive that is widely used in the market. 5,5’Indigodisulfonic Acid Disodium Salt was also used as a dye for cationic cotton fabrics.

Definition

ChEBI: An organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. It is an indicator at pH 11.5-14, changing from blue to yellow.

Preparation

3H-indol-3-one,2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro?with strong sulfuric acid or trace fuming sulfuric acid products.

brand name

Indigo Carmine (Becton Dickinson Microbiology).

General Description

Indigo to dark blue powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Sensitive to light. Very sensitive to oxidizing agents. Color is readily discharged by nitric acid, chlorates, etc. Color of aqueous solutions fades on standing.

Fire Hazard

Flash point data for Acid Blue 74 is not available, but Acid Blue 74 is probably combustible.

Purification Methods

Its solubility in H2O is 1g/100mL at 25o. It has been purified by dissolving in H2O, filtering and adding EtOH to cause the salt to separate. Wash the solid with EtOH, Et2O and dry in vacuo. [V.rlander & Schubert Chem Ber 34 1860 1901, UV: Smit et al. Anal Chem 27 1159 1955, Preisler et al. J Am Chem Soc 81 1991 1959, Beilstein 25 IV 1975.]

Properties and Applications

green light blue. Soluble in water for blue, slightly soluble in alcohol. The strong sulfuric acid is a deep blue light in purple, diluted into blue. In aqueous solution for green to yellow sodium hydroxide to join.

Standard Light Fastness Soaping Persperation Fastness Oxygen bleaching Fastness to seawater
Fading Stain Fading Stain Fading Stain
ISO 1-2 2 4 2 1 2 2 1
AATCC 1 3 5 1 1 1 2 2

References

American Society of Health-system Pharmacist.
Journal of Environmental Protection, 2016, 7, 1693-1706

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Indigo Carmine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43494
Advantage
61
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10578
Advantage
57
BEST-REAGENT
Tel
400-1166-196;028-84555506- ;028-84555506-
Email
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
Country
China
ProdList
11718
Advantage
57
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View Lastest Price from Indigo Carmine manufacturers

Dideu Industries Group Limited
Product
Indigo Carmine USP/EP/BP 860-22-0
Price
US $1.10/g
Min. Order
1g
Purity
0.999
Supply Ability
100 Tons min
Release date
2021-08-12
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Indigo Carmine 860-22-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg/month
Release date
2021-07-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
Acid Blue 74 860-22-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

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