ChemicalBook > CAS DataBase List > 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

Product Name
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
CAS No.
85547-22-4
Chemical Name
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
Synonyms
Apatamine;AAPTAMINE;6]naphtyridine;9-Dimethoxy-1H-benzo[de][1;8;9-DIMETHOXY-1H-BENZO[DE][1;6]NAPHTYRIDINE;6)naphthyridine,8,9-dimethoxy-1h-benzo(de)(;8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE;1H-Benzo[de][1,6]naphthyridine, 8,9-dimethoxy-
CBNumber
CB8243320
Molecular Formula
C13H12N2O2
Formula Weight
228.25
MOL File
85547-22-4.mol
More
Less

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Property

storage temp. 
4°C, protect from light
solubility 
DMSO: soluble,Ethanol: soluble
form 
Solid
color 
White to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
24297
Product name
Aaptamine
Packaging
500μg
Price
$149
Updated
2021/12/16
Cayman Chemical
Product number
24297
Product name
Aaptamine
Packaging
1mg
Price
$283
Updated
2021/12/16
TRC
Product number
A164268
Product name
Aaptamine
Packaging
1mg
Price
$170
Updated
2021/12/16
ChemScene
Product number
CS-0032464
Product name
Aaptamine
Purity
≥98.0%
Packaging
1mg
Price
$305
Updated
2021/12/16
AK Scientific
Product number
8722CA
Product name
Aaptamine
Packaging
1mg
Price
$482
Updated
2021/12/16
More
Less

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Chemical Properties,Usage,Production

Uses

Aaptamine is a spongean alkaloid that can activate the p21 promoter in the absence of p53 and can function as a proteasome inhibitor.

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 616, 1987 DOI: 10.1021/jo00380a024
Tetrahedron Letters, 31, p. 569, 1990 DOI: 10.1016/0040-4039(90)87037-Z

in vivo

Aaptamine (5-100 μg; intrathecal injection; single dose) has an analgesic effect in a rat model of chronic constriction injury (CCI)-induced peripheral neuropathy[7].

Animal Model:Chronic constriction injury treated adult male Wistar rats (250-285 g)[7]
Dosage:5, 30 and 100 μg
Administration:Intrathecal injection; single dose
Result:Showed different durations of analgesic effects on CCI-induced nociception. The 5 μg, 30 μg, and 100 μg doses presented analgesic durations of 90, 150, and 150 minutes respectively. However, the variance in the group administered with 100 μg of aaptamine was the largest, and the rats presented some abnormal motor behavior.

IC 50

AChE: 0.23 μg/mL (IC50); BChE: 1.38 μg/mL (IC50)

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Suppliers

China 50 Switzerland 1 United States 7 Global 58
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
Advantage
66
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai ChengShao Biological Technology Co., Ltd.
Tel
021-61847300 13341622919
Fax
021-61847300
Email
shcss01@163.com
Country
China
ProdList
4808
Advantage
58
Shanghai Uteam Biotechnology Co., Ltd.
Tel
021-36031160 13311776681
Email
3338195766@QQ.com
Country
China
ProdList
5093
Advantage
55
Shanghai Biological Technology Development Co., Ltd.
Tel
021-69955236-807 13918189704
Fax
021-65211385
Email
chinaruji@chinaruji.com
Country
China
ProdList
5095
Advantage
55
Chengdu Greenpure Biopharma CO.,Ltd
Tel
028-88203606; 18283602253
Email
jancyzheng@gcgreenpure.com
Country
China
ProdList
1594
Advantage
58

85547-22-4, 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINERelated Search:

Cevadine veratramine Xanthiside daurisoline VERATRIDINE 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one L-Hyoscyamine Xanthiazone Daurinoline menisdaurin 8-Aminoisoquinoline 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

  • 6)naphthyridine,8,9-dimethoxy-1h-benzo(de)(
  • AAPTAMINE
  • 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
  • Apatamine
  • 6]naphtyridine
  • 8;9-DIMETHOXY-1H-BENZO[DE][1;6]NAPHTYRIDINE
  • 9-Dimethoxy-1H-benzo[de][1
  • 1H-Benzo[de][1,6]naphthyridine, 8,9-dimethoxy-
  • 85547-22-4