ChemicalBook > CAS DataBase List > 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

Product Name: 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
CAS No.: 85547-22-4
Chemical Name: 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
Synonyms: Apatamine;AAPTAMINE;6]naphtyridine;9-Dimethoxy-1H-benzo[de][1;8;9-DIMETHOXY-1H-BENZO[DE][1;6]NAPHTYRIDINE;6)naphthyridine,8,9-dimethoxy-1h-benzo(de)(;8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE;1H-Benzo[de][1,6]naphthyridine, 8,9-dimethoxy-
CBNumber: CB8243320
Molecular Formula: C13H12N2O2
Formula Weight: 228.25
MOL File: 85547-22-4.mol

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8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Property

storage temp.: 4°C, protect from light
solubility: DMSO: soluble,Ethanol: soluble
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24297
Product name: Aaptamine
Packaging: 1mg
Price: $283
Updated: 2021/12/16

Cayman Chemical

Product number: 24297
Product name: Aaptamine
Packaging: 500μg
Price: $149
Updated: 2021/12/16

TRC

Product number: A164268
Product name: Aaptamine
Packaging: 1mg
Price: $170
Updated: 2021/12/16

ChemScene

Product number: CS-0032464
Product name: Aaptamine
Purity: ≥98.0%
Packaging: 1mg
Price: $305
Updated: 2021/12/16

AK Scientific

Product number: 8722CA
Product name: Aaptamine
Packaging: 1mg
Price: $482
Updated: 2021/12/16

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8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Chemical Properties,Usage,Production

Uses

Aaptamine is a spongean alkaloid that can activate the p21 promoter in the absence of p53 and can function as a proteasome inhibitor.

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 616, 1987 DOI: 10.1021/jo00380a024
Tetrahedron Letters, 31, p. 569, 1990 DOI: 10.1016/0040-4039(90)87037-Z

in vivo

Aaptamine (5-100 μg; intrathecal injection; single dose) has an analgesic effect in a rat model of chronic constriction injury (CCI)-induced peripheral neuropathy^[7].

Animal Model:	Chronic constriction injury treated adult male Wistar rats (250-285 g)^[7]
Dosage:	5, 30 and 100 μg
Administration:	Intrathecal injection; single dose
Result:	Showed different durations of analgesic effects on CCI-induced nociception. The 5 μg, 30 μg, and 100 μg doses presented analgesic durations of 90, 150, and 150 minutes respectively. However, the variance in the group administered with 100 μg of aaptamine was the largest, and the rats presented some abnormal motor behavior.

IC 50

AChE: 0.23 μg/mL (IC₅₀); BChE: 1.38 μg/mL (IC₅₀)

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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85547-22-4, 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINERelated Search:

Cevadine veratramine Xanthiside daurisoline VERATRIDINE 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one L-Hyoscyamine Xanthiazone Daurinoline menisdaurin 8-Aminoisoquinoline 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

6)naphthyridine,8,9-dimethoxy-1h-benzo(de)(

AAPTAMINE

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

Apatamine

6]naphtyridine

8;9-DIMETHOXY-1H-BENZO[DE][1;6]NAPHTYRIDINE

9-Dimethoxy-1H-benzo[de][1

1H-Benzo[de][1,6]naphthyridine, 8,9-dimethoxy-

85547-22-4