ChemicalBook > CAS DataBase List > 4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE

4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE

Product Name: 4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE
CAS No.: 52854-14-5
Chemical Name: 4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE
Synonyms: NSC 73560;4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE;Pyrimidine, 4-chloro-6-methoxy-5-nitro-
CBNumber: CB82446329
Molecular Formula: C5H4ClN3O3
Formula Weight: 189.56
MOL File: 52854-14-5.mol

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4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE Property

Melting point:: 66℃
Boiling point:: 343.1±37.0 °C(Predicted)
Density: 1.532±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -4.87±0.26(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C374963
Product name: 4-chloro-6-methoxy-5-nitropyrimidine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0133260
Product name: 4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $505.97
Updated: 2021/12/16

Ambeed

Product number: A137975
Product name: 4-Chloro-6-methoxy-5-nitropyrimidine
Purity: 95%
Packaging: 100mg
Price: $14
Updated: 2021/12/16

Ambeed

Product number: A137975
Product name: 4-Chloro-6-methoxy-5-nitropyrimidine
Purity: 95%
Packaging: 250mg
Price: $22
Updated: 2021/12/16

Ambeed

Product number: A137975
Product name: 4-Chloro-6-methoxy-5-nitropyrimidine
Purity: 95%
Packaging: 1g
Price: $78
Updated: 2021/12/16

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4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

4316-93-2

124-41-4

52854-14-5

Sodium methanolate (2.70 g, 50.0 mmol) was added batchwise to a stirred suspension of 4,6-dichloro-5-nitropyrimidine (4.85 g, 25.0 mmol) in methanol (90 ml) at 0 °C over 10 min. After addition, the reaction mixture was maintained at 0°C and continued to stir for 2 hours. After completion of the reaction, the precipitate was collected by filtration. The filtrate was concentrated to dryness and the resulting residue was suspended in isohexane and filtered again. The filtrate was concentrated and the residue was purified by rapid column chromatography on silica gel, using a 5% ethyl acetate solution in isohexane as eluent. The grades containing the target product were collected and concentrated to give 4-methoxy-5-nitro-6-chloropyrimidine (3.50 g, 74% yield) as a white solid.

References

[1] Patent: WO2004/41826, 2004, A1. Location in patent: Page 42
[2] Patent: EP2527344, 2012, A1. Location in patent: Page/Page column 34
[3] Patent: WO2012/160030, 2012, A1. Location in patent: Page/Page column 138-139
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 11, p. 1630 - 1640

4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE Suppliers

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52854-14-5, 4-CHLORO-6-METHOXY-5-NITROPYRIMIDINERelated Search:

2-methoxy-4-nitrophenol 5-Pyrimidinamine, 4-methoxy- (9CI) 6-Chloropyrimidin-4(3H)-one 4-CHLORO-5-NITROPYRIMIDINE 5-AMINO-4-CHLOROPYRIMIDINE 4-Chloro-6-methoxypyrimidine 4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE 4-HYDROXY-5-NITROPYRIMIDINE

4-CHLORO-6-METHOXY-5-NITROPYRIMIDINE

NSC 73560

Pyrimidine, 4-chloro-6-methoxy-5-nitro-

52854-14-5