Description References
ChemicalBook > CAS DataBase List > Esculin

Esculin

Description References
Product Name
Esculin
CAS No.
531-75-9
Chemical Name
Esculin
Synonyms
ESCULIN;Escosyl;BICOLOIN;AESCULIN;POLYDROM;Esculine;Bicolorin;Crataegin;Polychrom;vitaminc2
CBNumber
CB8245061
Molecular Formula
C15H16O9
Formula Weight
340.28
MOL File
531-75-9.mol
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Esculin Property

Melting point:
203 °C
alpha 
-88 º (c=2,dioxane/water1:1)
Boiling point:
396.1°C (rough estimate)
Density 
0.791 g/mL at 20 °C
vapor pressure 
0Pa at 25℃
refractive index 
-79 ° (C=2.4, 50% Dioxane)
Flash point:
15 °C
storage temp. 
2-8°C
solubility 
methanol: 50 mg/mL hot, clear to very faintly turbid, yellow-green fluoresc.
form 
Liquid
pka
7.00±0.20(Predicted)
color 
Clear
optical activity
[α]20/D 41±2°, c = 5% in pyridine
Water Solubility 
MODERATELY SOLUBLE
Merck 
3698
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
YRABYCJKUBFWQY-FHXAZYNBSA-N
LogP
-1.307 (est)
CAS DataBase Reference
531-75-9(CAS DataBase Reference)
NIST Chemistry Reference
7-Hydroxy-2-oxo-2h-chromen-6-yl hexopyranoside(531-75-9)
EPA Substance Registry System
Esculin (531-75-9)
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Safety

Hazard Codes 
F,C,Xi
Risk Statements 
11-20/21/22-34-68/20/21/22-36/37/38
Safety Statements 
26-36/37/39-45-24/25-36/37-16
RIDADR 
UN 2924 3/PG 2
WGK Germany 
3
RTECS 
DJ3085000
F 
3-10-23
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E8250
Product name
Esculin hydrate
Purity
≥98%
Packaging
5g
Price
$58.4
Updated
2024/03/01
Sigma-Aldrich
Product number
02350
Product name
Esculin hydrate
Purity
≥98.0%(HPLC)
Packaging
10g
Price
$83.6
Updated
2024/03/01
Sigma-Aldrich
Product number
02350
Product name
Esculin hydrate
Purity
≥98.0%(HPLC)
Packaging
50g
Price
$302
Updated
2024/03/01
Sigma-Aldrich
Product number
06212
Product name
Esculin hydrate
Purity
analytical standard
Packaging
100mg
Price
$75.4
Updated
2022/05/15
Sigma-Aldrich
Product number
Y0001612
Product name
Esculin
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001612
Price
$153
Updated
2024/03/01
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Esculin Chemical Properties,Usage,Production

Description

Aesculin (also Esculin) is a glucoside compound, which occurs naturally in unprocessed seeds, leaves, bark, and flowers of horse chestnut. Aesculin is used for the identification of bacteria, for the treatment of hemorrhoids and venous peripheral diseases. In cosmetics, aesculin was found to be effective in the treatment of aging skin. Owing to its ultraviolet absorbing activity, aesculin is employed in tanning preparations. Aesculin can be also used as a substrate for the detection of ß-gluocosidase activity in polyacrylamide gels.

References

[1] Anna D. Orla-Jensen, About the application of aesculin for the identification of bacteria, APMIS, 1934, vol. 11, 312-322
[2] S. Srijayanta, A. Raman and B. L. Goodwin, A comparative study of the constituents of Aesculus hippocastanum and Aesculus indica, Journal of Medical Food, 1999, vol. 2, 45-50
[3] Ki-Sun Kwon, Jaehoon Lee, Hyung Gyoo Kang and Yung Chil Hah, Detection of ß-Glucosidase Activity in Polyacrylamide Gels with Esculin as Substrate, Appl. Environ. Microbil., 1994, vol. 80, 4584-4586
[4] Dennis J Mckenna, Kenneth Jones, Kerry Hughes and Virginia M Tyler, Botanical Medicines: The Desk Reference for Major Herbal Supplements, Second Edition, 2011

Chemical Properties

White to nearly white

Uses

esculin is used as a skin protectant in ointments and creams. This is a glucoside compound originally obtained from the leaves and bark of the horse chestnut tree.

Uses

esculoside is utilized in formulations for the treatment of cellulite. es culoside is apparently beneficial for impaired microcirculation.

Uses

Esculin hydrate has been used as a component of sporulation-inducing esculin agar. It has also been used for esculin uptake assay.

Definition

ChEBI: A hydroxycoumarin that is the 6-O-beta-D-glucoside of esculetin.

General Description

Esculin hydrate has vasoprotective and venotonic properties.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Esculin is a coumarin glycoside that demonstrates antioxidant activitites and protection against chemically-induced carcinogenesis. Esculin is utilized in microbiology for the isolation and identification of Enterococcus (group D streptococci).

Esculin Preparation Products And Raw materials

Raw materials

Preparation Products

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Esculin Suppliers

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View Lastest Price from Esculin manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Esculin 531-75-9
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-15
R&D Scientific Inc.
Product
Esculin 531-75-9
Price
US $780.00/Kg
Min. Order
1Kg
Purity
98
Supply Ability
500 Kg
Release date
2024-06-24
Hebei Kingfiner Technology Development Co.Ltd
Product
ESCULIN 531-75-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000%
Release date
2023-11-27

531-75-9, EsculinRelated Search:

Isofraxidin Tetrahydro-4H-pyran-4-one Centchroman Tetrahydrofuran FRAXIN Furazolidone CHLOROPHOSPHONAZO III Esculin aglucon,Esculin aglycon D-(-)-Salicin Icariin Matrine ERIOCITRIN AESCIN IB(SH) Eribulin Erlotinib hydrochloride Eribulin Mesylate ERIODICTYOL-7-GLUCOSIDE 4-Ethoxyphenol

  • BICOLOIN
  • ESCULETIN-6-O-GLUCOSIDE
  • ESCULIN
  • ESCULETIN-6-GLUCOSIDE
  • ESCULOSIDE
  • Esculinsesquimonohydrate
  • 2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy-
  • 6,7-DIHYDROXYCOUMARIN-6-O-GLUCOSIDE
  • 6-(beta-d-glucopyranosyloxy)-7-hydroxy-2h-1-benzopyran-2-one
  • 6-(BETA-D-GLUCOPYRANOSYLOXY)-7-HYDROXY-2H-1-BEZOPYRAN-2-ONE
  • 6-(β-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one
  • 6,7-Dihydrocoumarin-6-glucoside
  • 6-β-Glucosido-7-hydrox
  • Aesculin;Bicolorin;6,7-Dihydrocoumarin-6-glucoside;6,7-Dihydroxycoumarin 6-glucoside;Enallachrome;Escosyl;Esculetin-6-β-D-glucopyranoside;Esculin;Esculinic acid;Esculoside;6-(β-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one;6-β-Glucosido-7-hydrox
  • Esculinic acid
  • ESCULIN, PLANT EXTRACT 10:1
  • AESCULIN (Esculin Sesquihydrate)
  • EsculinNLT98%
  • 7-hydroxycoumarin-6-yl beta-d-glucopyranoside
  • ESCULIN(ESCULETIN-6-GLUCOSIDE)(P)
  • 7-HYDROXY-6-O-GLUCOSYLCOUMARIN
  • 6-(β-D-Glucopyranosyloxy)-7-hydroxycoumarin
  • ESCULIN extrapure
  • 7-hydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1-benzopyran-2-one hydrate
  • AESCULETIN
  • AESCULETIN-6B-D-GLUCOPYRANOSIDE
  • AESCULETIN-6-BETA-D-GLUCOPYRANOSIDE
  • AESCULIN
  • POLYDROM
  • POLYCHROME
  • 6-(beta-d-glucopyranosyloxy)-7-hydroxy-2h-1-benzopyran-2-on
  • Bicolorin
  • Crataegin
  • Enallachrome
  • Escosyl
  • Esculetin 6-beta-D-glucoside
  • Esculine
  • Polychrom
  • Vitamin C2
  • vitaminc2
  • 6,7-DIHYDROXYCOUMARIN 6-GLUCOSIDE
  • Esculin，Esculine
  • 6-(b-D-Glucopyranosyloxy)-7-hydroxycoumarin
  • Esculetin 6-b-D-glucoside
  • Esculin hydrate,97%
  • 6-glucoside hydrate
  • F. bangeana DC.p.e
  • 6-glucoside hydrat
  • 7-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chroMen-2-one
  • Esculin hydrate, 97% 10GR
  • Aesculin (Esculin)
  • Schillerstoff
  • 2H-1-Benzopyran-2-one,6-(b-D-glucopyranosyloxy)-7-hydroxy-
  • 2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-
  • 6,7-dihydroxychromen-2-one 6-β-D-glucoside
  • 6,7-dihydroxycoumarin 6-β-D-glucoside
  • 7-hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy- 6-(hydroxymethyl)-2-tetrahydropyranyl]oxy}-2-chromenone
  • Esculetin 6-β-D-glucoside