ChemicalBook > CAS DataBase List > Lorcaserin hydrochloride

Lorcaserin hydrochloride

Product Name
Lorcaserin hydrochloride
CAS No.
846589-98-8
Chemical Name
Lorcaserin hydrochloride
Synonyms
LORCASERIN HCL;Lorca Hydrochloride;(R)-1H-3-BENZAZEPINE;LORCASERIN HCL/Belviq;Lorcaserin hydrochloride;R Lorcaserin hydrochloride;Lorcaserin Hydrochloride (>Thiosildenafil Solution, 100ppm;Lorcaserin (hydrochloride) (CRM);Lorcaserin Hydrochloride (>50% ee)
CBNumber
CB82451004
Molecular Formula
C11H15Cl2N
Formula Weight
232.15
MOL File
846589-98-8.mol
More
Less

Lorcaserin hydrochloride Property

solubility 
Soluble in DMSO > 10 mM
form 
Powder
Stability:
Hygroscopic
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
15521
Product name
Lorcaserin (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15521
Product name
Lorcaserin (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
19247
Product name
Lorcaserin (hydrochloride) (CRM)
Packaging
1mg
Price
$238
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0024533
Product name
LORCASERIN HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$504.69
Updated
2021/12/16
Abosyn
Product number
61-10511
Product name
(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepinehydrochloride
Purity
95-98%
Packaging
1g
Price
$135
Updated
2021/12/16
More
Less

Lorcaserin hydrochloride Chemical Properties,Usage,Production

Description

In June 2012, the US FDA approved lorcaserin for chronic weight management in adult patients who are characterized as overweight or obese and have at least one comorbid, weight-related condition. Lorcaserin (also known as APD356) is the first 5-HT2C agonist approved for chronic weight management since the withdrawal of the 5-HT2C agonist fenfluramine in 1997 due to rare cases of cardiac valvulopathy. The serotonin receptor 5-HT2C is found primarily in the hypothalamus and regulates appetite and feeding behavior. Safety issues with fenfluramine were associated with poor selectivity for 5-HT2C versus 5HT2A and 5HT2B. Ring constraint afforded by the benzazepine in lorcaserin improved selectivity for 5HT2C by over 2 log units.

Description

Lorcaserin (hydrochloride) (CRM) (Item No. 19247) is a certified reference material categorized as an anorectic. It also decreases oxycodone intake and has positive effects on self-administration and relapse vulnerability in the rat. Lorcaserin is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

Originator

Pharmaceuticals (United States)

Uses

Lorcaserin hydrochloride, a novel antiobesity drug, is a selective serotonin 5-HT2C receptor agonist, approved by FDA in 2012.

Definition

ChEBI: A hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid. Used as an anti-obesity drug.

brand name

Belviq

Side effects

Lorcaserin hydrochloride (Belviq) is a serotonin 2C receptor agonist that causes weight loss by causing appetite suppression.It appears to have fewer adverse effects than orlistat,although long-term safety data are limited. The recommended dosage is 10mg twice daily. Lorcaserin should be discontinued if patients do not lose 5% of their body weight in 12 weeks. The efficacy of lorcaserin appears similar to that of orlistat (mean difference in weight loss between active and placebo-treated groups approximately 3-4 kg).Common side effects include nausea, headache,dizziness, nasopharyngitis, and fatigue. Lorcaserin may increasethe risk of symptomatic hypoglycemia in patients with type 2 diabetes on oral agents, necessitating a reduction in the dose of diabetes medications. Lorcaserin should not be used in individuals with creatinine clearance <30 mL/minute. It is contraindicated during pregnancy. In addition, lorcaserin should not be used with other serotonergic drugs (e.g., selective serotonin reuptake inhibitors,selective serotonin-norepinephrine reuptake inhibitors, bupropion[Wellbutrin], tricyclic antidepressants,and monamine oxidase inhibitors)because of the theoretical potential for serotonin syndrome.
https://www.accessdata.fda.gov
https://medlineplus.gov

Drug interactions

Belviq (lorcaserin hydrochloride) may interact with antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), triptans, bupropion, dextromethorphan, or St. John's Wort.

Precautions

The precautions of BELVIQ (lorcaserin hydrochloride) tablets:
Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)- like Reactions: The safety of coadministration with other serotonergic or antidopaminergic agents has not been established.
Valvular heart disease: If signs or symptoms develop, consider BELVIQ discontinuation and evaluate the patient for possible valvulopathy.
Cognitive Impairment: This may cause disturbances in attention or memory. Caution with the use of hazardous machinery when starting BELVIQ treatment.
Psychiatric Disorders, including euphoria and dissociation: Do not exceed the recommended dose of 10 mg twice daily.
Monitor for depression or suicidal thoughts. Discontinue if symptoms develop.
Use of Antidiabetic Medications: Weight loss may cause hypoglycemia. Monitor blood glucose. BELVIQ has not been studied in patients taking insulin.
Priapism: Patients should seek emergency treatment if an erection lasts >4 hours. Use BELVIQ with caution in patients predisposed to priapism.

Lorcaserin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Lorcaserin hydrochloride Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38463
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
W & J PharmaChem, Inc.
Tel
--
Fax
--
Email
info@wjpharmachem.com
Country
United States
ProdList
595
Advantage
50
Fragmenta
Tel
--
Fax
--
Email
sales@fragmenta.com
Country
United States
ProdList
1068
Advantage
0
More
Less

View Lastest Price from Lorcaserin hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
R-Lorcaserin hydrochloride 846589-98-8
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-06
Hebei Yanxi Chemical Co., Ltd.
Product
Lorcaserin hydrochloride 846589-98-8
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-09
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Lorcaserin hydrochloride 846589-98-8
Price
US $30.00-300.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-20

846589-98-8, Lorcaserin hydrochlorideRelated Search:


  • (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
  • LORCASERIN HCL
  • Lorcaserin hydrochloride
  • (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
  • (1R)-8-chloro-1-Methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  • lorcaserin hydrochloride (APD-356)
  • R Lorcaserin hydrochloride
  • Green Card mianserin hydrochloride
  • (R)-1H-3-BENZAZEPINE
  • (R)-8-Chloro-1-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride
  • Lorcaserin Hydrochloride (>50% ee)
  • 1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-Methyl-, hydrochloride (1:1), (1R)-
  • Thiosildenafil Solution, 100ppm
  • Lorcaserin hydrochloride, 98%, a selective full agonist of human 5-HT2C receptor
  • Lorcaserin (hydrochloride) (CRM)
  • LORCASERIN HCL;APD-356;APD356;APD 356
  • Lorcaserin Hydrochloride (&gt
  • Lorcaserin Hydrochloride Solution in Methanol, 1000 ug/ml
  • R-Lorcaserin hydrochloride USP/EP/BP
  • (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE USP/EP/BP
  • Lorcaserin HCl , Lorcaserin Hydrochloride
  • C11H15Cl2N (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE 846589-98-8
  • Lorca Hydrochloride
  • Lorcaserin hydrochloride GMP Standard Raw Powder
  • (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE LORCASERINE (Int.)
  • LORCASERIN HCL/Belviq
  • 846589-98-8
  • 646202-80-0
  • 616202-80-0
  • APIs
  • 5-HT 2c receptor agonist
  • Inhibitors
  • 1