3-Aminophthalimide
- Product Name
- 3-Aminophthalimide
- CAS No.
- 2518-24-3
- Chemical Name
- 3-Aminophthalimide
- Synonyms
- 3-AMINOPHTHALIMIDE;3-Amino-phthalamide;4-Amino-1H-isoindole;3-AMINOPHTHALIMIDE 99%;3-Aminophthalimide,99%;4-Amino-isoindole-1,3-dione;4-Aminoisoindoline-1,3-dione;4-amino-1h-isoindole-3(2h)-dione;4-AMINO-1H-ISOINDOLE-1,3(2H)-DIONE;1H-Isoindole-1,3(2H)-dione,4-amino-
- CBNumber
- CB8249564
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 2518-24-3.mol
3-Aminophthalimide Property
- Melting point:
- 268.5-273.5 °C (lit.)
- Boiling point:
- 288.82°C (rough estimate)
- Density
- 1.3264 (rough estimate)
- refractive index
- 1.5770 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.76±0.20(Predicted)
- Appearance
- Yellow to orange Solid
- CAS DataBase Reference
- 2518-24-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 3-Aminophthalimide(2518-24-3)
- EPA Substance Registry System
- 1H-Isoindole-1,3(2H)-dione, 4-amino- (2518-24-3)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 22-26-36/37-45
- WGK Germany
- 3
- HS Code
- 29251995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3555
- Product name
- 4-Aminoisoindoline-1,3-dione
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $104
- Updated
- 2025/07/31
- Product number
- A3555
- Product name
- 4-Aminoisoindoline-1,3-dione
- Purity
- min. 95.0 %
- Packaging
- 25G
- Price
- $311
- Updated
- 2025/07/31
- Product number
- 081500
- Product name
- 4-Amino-1H-isoindole-1,3(2H)-dione
- Purity
- 97%
- Packaging
- 1g
- Price
- $194
- Updated
- 2021/12/16
- Product number
- FA139690
- Product name
- 4-Aminoisoindoline-1,3-dione
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- I658
- Product name
- 3-Aminophthalimide
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
3-Aminophthalimide Chemical Properties,Usage,Production
Chemical Properties
yellow fine powder
Uses
3-Aminophthalimide may be used in direct chemiluminescent cellular bioassays. It may also be used in the preparation of 3-bromopthalimide.
General Description
3-Aminophthalimide (API) is a stable precursor of luminol. API can be prepared by the hydrogenation of 3-nitrophthalimide and methanol in the presence of 10% Pd-C.
Synthesis
603-62-3
2518-24-3
The general procedure for the synthesis of 3-amino phthalimide from 3-nitrophthalimide was as follows: 3-nitrophthalimide (LOOGR) was placed in a hydrogenation reactor and dissolved by adding 500 mL of dimethylformamide (DMF). Subsequently, 20 g of wet Ruanne nickel catalyst was added to the solution. The hydrogenation reaction was started by applying a hydrogen pressure of 20-40 psi at 20-30 °C. After the initial exothermic phase of the reaction, the hydrogen pressure was increased to 40-60 psi and the reaction temperature was raised to 40-50 °C to continue the reaction. After the hydrogen is completely absorbed, a sample is taken and analyzed by thin layer chromatography (TLC) to confirm that the 3-nitrophthalimide has been completely converted. Upon completion of the reaction, the reaction mixture was filtered while hot to remove the catalyst. The filtrate was concentrated under reduced pressure at 60-80 °C to remove the solvent. To the residue was added 500 mL of water and stirred for 20-30 minutes. The product was separated by filtration and dried at 60-70 °C to give a yellow crystalline solid 3-aminophthalimide (80 g, 95% yield). The melting point of the product was 262-264 °C.
References
[1] MedChemComm, 2016, vol. 7, # 2, p. 292 - 296
[2] Patent: WO2004/43919, 2004, A1. Location in patent: Page 6
[3] Patent: WO2004/43919, 2004, A1. Location in patent: Page 7
[4] Patent: WO2004/43919, 2004, A1. Location in patent: Page 7
[5] Journal of Chemical Research, 2011, vol. 35, # 6, p. 326 - 328
3-Aminophthalimide Preparation Products And Raw materials
Raw materials
Preparation Products
3-Aminophthalimide Suppliers
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View Lastest Price from 3-Aminophthalimide manufacturers
- Product
- 3-Aminophthalimide 2518-24-3
- Price
- US $209.30/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 99.00%HPLC
- Supply Ability
- 4tons/month
- Release date
- 2021-09-23
- Product
- 3-Aminophthalimide 2518-24-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-01-29