3-Aminophthalimide

Product Name: 3-Aminophthalimide
CAS No.: 2518-24-3
Chemical Name: 3-Aminophthalimide
Synonyms: 3-AMINOPHTHALIMIDE;3-Amino-phthalamide;4-Amino-1H-isoindole;3-AMINOPHTHALIMIDE 99%;3-Aminophthalimide,99%;4-Amino-isoindole-1,3-dione;4-Aminoisoindoline-1,3-dione;4-amino-1h-isoindole-3(2h)-dione;4-AMINO-1H-ISOINDOLE-1,3(2H)-DIONE;1H-Isoindole-1,3(2H)-dione,4-amino-
CBNumber: CB8249564
Molecular Formula: C8H6N2O2
Formula Weight: 162.15
MOL File: 2518-24-3.mol

More

Less

3-Aminophthalimide Property

Melting point:: 268.5-273.5 °C (lit.)
Boiling point:: 288.82°C (rough estimate)
Density: 1.3264 (rough estimate)
refractive index: 1.5770 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.76±0.20(Predicted)
Appearance: Yellow to orange Solid
CAS DataBase Reference: 2518-24-3(CAS DataBase Reference)
NIST Chemistry Reference: 3-Aminophthalimide(2518-24-3)
EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 4-amino- (2518-24-3)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42/43
Safety Statements: 22-26-36/37-45
WGK Germany: 3
HS Code: 29251995

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: A3555
Product name: 4-Aminoisoindoline-1,3-dione
Purity: min. 95.0 %
Packaging: 5G
Price: $104
Updated: 2025/07/31

TCI Chemical

Product number: A3555
Product name: 4-Aminoisoindoline-1,3-dione
Purity: min. 95.0 %
Packaging: 25G
Price: $311
Updated: 2025/07/31

Matrix Scientific

Product number: 081500
Product name: 4-Amino-1H-isoindole-1,3(2H)-dione
Purity: 97%
Packaging: 1g
Price: $194
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA139690
Product name: 4-Aminoisoindoline-1,3-dione
Packaging: 500mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: I658
Product name: 3-Aminophthalimide
Packaging: 1g
Price: $54
Updated: 2021/12/16

More

Less

3-Aminophthalimide Chemical Properties,Usage,Production

Chemical Properties

yellow fine powder

Uses

3-Aminophthalimide may be used in direct chemiluminescent cellular bioassays. It may also be used in the preparation of 3-bromopthalimide.

General Description

3-Aminophthalimide (API) is a stable precursor of luminol. API can be prepared by the hydrogenation of 3-nitrophthalimide and methanol in the presence of 10% Pd-C.

Synthesis

603-62-3

2518-24-3

The general procedure for the synthesis of 3-amino phthalimide from 3-nitrophthalimide was as follows: 3-nitrophthalimide (LOOGR) was placed in a hydrogenation reactor and dissolved by adding 500 mL of dimethylformamide (DMF). Subsequently, 20 g of wet Ruanne nickel catalyst was added to the solution. The hydrogenation reaction was started by applying a hydrogen pressure of 20-40 psi at 20-30 °C. After the initial exothermic phase of the reaction, the hydrogen pressure was increased to 40-60 psi and the reaction temperature was raised to 40-50 °C to continue the reaction. After the hydrogen is completely absorbed, a sample is taken and analyzed by thin layer chromatography (TLC) to confirm that the 3-nitrophthalimide has been completely converted. Upon completion of the reaction, the reaction mixture was filtered while hot to remove the catalyst. The filtrate was concentrated under reduced pressure at 60-80 °C to remove the solvent. To the residue was added 500 mL of water and stirred for 20-30 minutes. The product was separated by filtration and dried at 60-70 °C to give a yellow crystalline solid 3-aminophthalimide (80 g, 95% yield). The melting point of the product was 262-264 °C.

References

[1] MedChemComm, 2016, vol. 7, # 2, p. 292 - 296
[2] Patent: WO2004/43919, 2004, A1. Location in patent: Page 6
[3] Patent: WO2004/43919, 2004, A1. Location in patent: Page 7
[4] Patent: WO2004/43919, 2004, A1. Location in patent: Page 7
[5] Journal of Chemical Research, 2011, vol. 35, # 6, p. 326 - 328

3-Aminophthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-Aminophthalimide Suppliers

Belgium 2 China 130 Germany 2 India 3 Japan 1 Slovakia 1 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 6 United States 15 Global 163

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

ChemService Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6379
Advantage: 68

Ryan Scientific, Inc.

Tel: --
Fax: --
Email: ryan.reichlyn@ryansci.com
Country: United States
ProdList: 6439
Advantage: 60

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

Acros Organics USA

Tel: --
Fax: --
Email: eveleth@fisherchem.com
Country: United States
ProdList: 3846
Advantage: 81

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

More

Less

View Lastest Price from 3-Aminophthalimide manufacturers

Asia Chem I and E (Jiangsu) Co Ltd

Product: 3-Aminophthalimide 2518-24-3
Price: US $209.30/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 4tons/month
Release date: 2021-09-23

Career Henan Chemical Co

Product: 3-Aminophthalimide 2518-24-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-01-29

2518-24-3, 3-AminophthalimideRelated Search:

O-Phthalimide 4-Dimethylaminobenzoic acid 4-Dimethylaminopyridine N-Hydroxyphthalimide Betaine 4-Dimethylaminobenzaldehyde Potassium phthalimide Glycine 4-Nitrophthalimide ALTRENOGEST N-Methylphthalimide 2-Dimethylaminoethanol 4-AMINOPHTHALIMIDE 98%,4-AMINOPHTHALIMIDE,4-Aminophthalimide, 97% (UV-VIS) 3-Nitrophthalimide Disperse Blue 60 4,11-diamino-1H-naphth[2,3-f]isoindole-1,3,5,10(2H)-tetrone N-Aminophthalimide, 90%, tech.,N-AMINOPHTHALIMIDE, TECH., 90%,N-AMINOPHTHALIMIDE (4-AMINO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID

1H-Isoindole-1,3(2H)-dione, 4-amino-

4-?mino-2,3-dihydro-1H-isoindole-1,3-dione

1H-Isoindole-1,3(2H)-dione,4-amino-

3-Amino-phthalamide

4-amino-1h-isoindole-3(2h)-dione

4-Amino-isoindole-1,3-dione

3-AMINOPHTHALIMIDE

4-AMINO-1H-ISOINDOLE-1,3(2H)-DIONE

4-Amino-1H-isoindole

3-AMINOPHTHALIMIDE[4-AMINO-1H-ISOINDOLE-1,3(2H)-DIONE]

3-AMINOPHTHALIMIDE 99%

4-Aminoisoindoline-1,3-dione

3-Aminophthalimide,99%

4-aMino-2,3-dihydro-1H-isoindole-1,3-dione

2518-24-3

Carbonyl Compounds

Building Blocks

Cyclic Imides

Organic Building Blocks

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Cyclic Imides

Organic Building Blocks

Carbonyl Compounds

Cyclic Imides

Organic Building Blocks

Amines and Anilines

Heterocycles