Nsc66811

Product Name: Nsc66811
CAS No.: 6964-62-1
Chemical Name: Nsc66811
Synonyms: Nsc66811;NSC 66811; NSC66811; NSC-66811;7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol;7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol;2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol;2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol;8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-;8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
CBNumber: CB82498106
Molecular Formula: C23H20N2O
Formula Weight: 340.42
MOL File: 6964-62-1.mol

More

Less

Nsc66811 Property

Melting point:: 143.0 to 147.0 °C
Boiling point:: 529.5±45.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in DMSO (up to 25 mg/ml).
form: solid
pka: 4.42±0.50(Predicted)
color: White
λmax: 250nm(EtOH)(lit.)
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

More

Less

Safety

HS Code: 2933.49.7000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 444144
Product name: MDM2 Antagonist II, NSC 66811
Purity: The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.
Packaging: 10MG
Price: $219
Updated: 2023/06/20

TCI Chemical

Product number: M2390
Product name: 2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
Purity: >98.0%(GC)
Packaging: 25mg
Price: $77
Updated: 2024/03/01

TCI Chemical

Product number: M2390
Product name: 2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
Purity: >98.0%(GC)
Packaging: 100mg
Price: $191
Updated: 2024/03/01

Cayman Chemical

Product number: 16431
Product name: NSC 66811
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16431
Product name: NSC 66811
Purity: ≥95%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

More

Less

Nsc66811 Chemical Properties,Usage,Production

Description

NSC 66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.

Uses

NSC 66811 is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. NSC 66811 activates p53 in colon cancer cells.

References

1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759

Nsc66811 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Nsc66811 Suppliers

Americas 1 China 87 Europe 1 France 1 India 2 Japan 1 United Kingdom 1 United States 13 Global 107

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Wuhan Luohua Medical Technology Co.,Ltd.

Tel: 13477084141; 13477084141
Fax: +86(27)65566697
Email: sales@luohuapharm.com
Country: China
ProdList: 469
Advantage: 60

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Wuxi Zhangkun Biochemical Technology Co., Ltd.

Tel: +86 0510-85629785
Fax: +86 0510-85625359
Country: China
ProdList: 2327
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

6964-62-1, Nsc66811Related Search:

17-AAG TYRPHOSTIN AG 1296 CL 82198 HYDROCHLORIDE AAL-993 (S)-(+)-Benzyl glycidyl ether N-Ethylaniline N-Methylaniline o-Toluidine N-Benzylideneaniline

Nsc66811

2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol

7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol

2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol

7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol

8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-

NSC 66811; NSC66811; NSC-66811

8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline

6964-62-1