Nsc66811

Product Name: Nsc66811
CAS No.: 6964-62-1
Chemical Name: Nsc66811
Synonyms: Nsc66811;NSC 66811; NSC66811; NSC-66811;7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol;7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol;2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol;2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol;8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-;8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
CBNumber: CB82498106
Molecular Formula: C23H20N2O
Formula Weight: 340.42
MOL File: 6964-62-1.mol

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Nsc66811 Property

Melting point:: 143.0 to 147.0 °C
Boiling point:: 529.5±45.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in DMSO (up to 25 mg/ml).
form: solid
pka: 4.42±0.50(Predicted)
color: White
λmax: 250nm(EtOH)(lit.)
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

HS Code: 2933.49.7000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 444144
Product name: MDM2 Antagonist II, NSC 66811
Purity: The MDM2 Antagonist II, NSC 66811, also referenced under CAS 6964-62-1, controls the biological activity of MDM2.
Packaging: 10MG
Price: $219
Updated: 2023/06/20

TCI Chemical

Product number: M2390
Product name: 2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
Purity: >98.0%(GC)
Packaging: 25mg
Price: $77
Updated: 2024/03/01

TCI Chemical

Product number: M2390
Product name: 2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
Purity: >98.0%(GC)
Packaging: 100mg
Price: $191
Updated: 2024/03/01

Cayman Chemical

Product number: 16431
Product name: NSC 66811
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16431
Product name: NSC 66811
Purity: ≥95%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

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Nsc66811 Chemical Properties,Usage,Production

Description

NSC 66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.

Uses

NSC 66811 is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. NSC 66811 activates p53 in colon cancer cells.

References

1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759

Nsc66811 Preparation Products And Raw materials

Raw materials

Preparation Products

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Nsc66811 Suppliers

Americas 1 China 87 Europe 1 France 1 India 2 Japan 1 United Kingdom 1 United States 13 Global 107

3B Pharmachem (Wuhan) International Co.,Ltd.

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6964-62-1, Nsc66811Related Search:

17-AAG TYRPHOSTIN AG 1296 CL 82198 HYDROCHLORIDE AAL-993 (S)-(+)-Benzyl glycidyl ether N-Ethylaniline N-Methylaniline o-Toluidine N-Benzylideneaniline

Nsc66811

2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol

7-(alpha-Anilinobenzyl)-2-methyl-8-quinolinol

2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol

7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol

8-Quinolinol,2-methyl-7-[phenyl(phenylamino)methyl]-

NSC 66811; NSC66811; NSC-66811

8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline

6964-62-1