6-Bromo-5-chloro-2-pyridinamine
- Product Name
- 6-Bromo-5-chloro-2-pyridinamine
- CAS No.
- 1004294-58-9
- Chemical Name
- 6-Bromo-5-chloro-2-pyridinamine
- Synonyms
- 3-Amino-3-fluoropyridine;6-Bromo-5-chloro-2-pyridinamine;6-BroMo-5-chloropyridin-2-aMine;2-Amino-6-bromo-5-chloropyridine;2-Amino-5-chloro-6-bromopyridine;2-PyridinaMine, 6-broMo-5-chloro-;6-BroMo-5-chloro-pyridin-2-ylaMine
- CBNumber
- CB82500713
- Molecular Formula
- C5H4BrClN2
- Formula Weight
- 207.46
- MOL File
- 1004294-58-9.mol
6-Bromo-5-chloro-2-pyridinamine Property
- Boiling point:
- 304.2±37.0 °C(Predicted)
- Density
- 1.834
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.26±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B678445
- Product name
- 6-Bromo-5-chloro-2-pyridinamine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B678445
- Product name
- 6-Bromo-5-chloro-2-pyridinamine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 0201AA
- Product name
- 6-Bromo-5-chloropyridin-2-amine
- Packaging
- 100mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- 0201AA
- Product name
- 6-Bromo-5-chloropyridin-2-amine
- Packaging
- 250mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- 143695
- Product name
- 6-Bromo-5-chloro-2-pyridinamine
- Purity
- 95%
- Packaging
- 5g
- Price
- $1203
- Updated
- 2021/12/16
6-Bromo-5-chloro-2-pyridinamine Chemical Properties,Usage,Production
Synthesis
19798-81-3
1004294-58-9
6-Bromo-2-pyridinamine (15 g, 87 mmol) was used as a raw material, which was mixed with acetonitrile (170 mL) and N-chlorosuccinimide (14 g, 100 mmol), and heated under nitrogen protection with reflux stirring. After 18 hours of reaction, the reaction mixture was concentrated and the residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic layer was separated and washed sequentially with saturated aqueous sodium bicarbonate solution and brine, followed by drying with sodium sulfate and filtration. Silica gel (45 g) was added to the filtrate and volatiles were removed under vacuum. The residue was purified by silica gel column chromatography using a gradient elution (hexane-ethyl acetate, 6:1 to 4:1). The product obtained from the isolation was dissolved in dichloromethane, silica gel (25 g) was added and the volatiles were again removed under vacuum. Finally, the residue was further purified by silica gel column chromatography (dichloromethane-pentane, 2:1) to give 6-bromo-5-chloro-2-pyridinamine (9.8 g) as a colorless solid.
References
[1] Patent: WO2015/97122, 2015, A1. Location in patent: Page/Page column 102; 103
[2] Patent: WO2014/63068, 2014, A1. Location in patent: Paragraph 00403
[3] Patent: WO2018/42316, 2018, A1. Location in patent: Page/Page column 122
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9663 - 9679
[5] Patent: WO2012/101063, 2012, A1. Location in patent: Page/Page column 98
6-Bromo-5-chloro-2-pyridinamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromo-5-chloro-2-pyridinamine manufacturers
- Product
- 6-Bromo-5-chloro-2-pyridinamine 1004294-58-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03