6-Bromo-5-chloro-2-pyridinamine

Product Name: 6-Bromo-5-chloro-2-pyridinamine
CAS No.: 1004294-58-9
Chemical Name: 6-Bromo-5-chloro-2-pyridinamine
Synonyms: 3-Amino-3-fluoropyridine;6-Bromo-5-chloro-2-pyridinamine;6-BroMo-5-chloropyridin-2-aMine;2-Amino-6-bromo-5-chloropyridine;2-Amino-5-chloro-6-bromopyridine;2-PyridinaMine, 6-broMo-5-chloro-;6-BroMo-5-chloro-pyridin-2-ylaMine
CBNumber: CB82500713
Molecular Formula: C5H4BrClN2
Formula Weight: 207.46
MOL File: 1004294-58-9.mol

More

Less

6-Bromo-5-chloro-2-pyridinamine Property

Boiling point:: 304.2±37.0 °C(Predicted)
Density: 1.834
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.26±0.10(Predicted)
Appearance: White to off-white Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B678445
Product name: 6-Bromo-5-chloro-2-pyridinamine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B678445
Product name: 6-Bromo-5-chloro-2-pyridinamine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 0201AA
Product name: 6-Bromo-5-chloropyridin-2-amine
Packaging: 100mg
Price: $99
Updated: 2021/12/16

AK Scientific

Product number: 0201AA
Product name: 6-Bromo-5-chloropyridin-2-amine
Packaging: 250mg
Price: $123
Updated: 2021/12/16

Matrix Scientific

Product number: 143695
Product name: 6-Bromo-5-chloro-2-pyridinamine
Purity: 95%
Packaging: 5g
Price: $1203
Updated: 2021/12/16

More

Less

6-Bromo-5-chloro-2-pyridinamine Chemical Properties,Usage,Production

Synthesis

19798-81-3

1004294-58-9

6-Bromo-2-pyridinamine (15 g, 87 mmol) was used as a raw material, which was mixed with acetonitrile (170 mL) and N-chlorosuccinimide (14 g, 100 mmol), and heated under nitrogen protection with reflux stirring. After 18 hours of reaction, the reaction mixture was concentrated and the residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic layer was separated and washed sequentially with saturated aqueous sodium bicarbonate solution and brine, followed by drying with sodium sulfate and filtration. Silica gel (45 g) was added to the filtrate and volatiles were removed under vacuum. The residue was purified by silica gel column chromatography using a gradient elution (hexane-ethyl acetate, 6:1 to 4:1). The product obtained from the isolation was dissolved in dichloromethane, silica gel (25 g) was added and the volatiles were again removed under vacuum. Finally, the residue was further purified by silica gel column chromatography (dichloromethane-pentane, 2:1) to give 6-bromo-5-chloro-2-pyridinamine (9.8 g) as a colorless solid.

References

[1] Patent: WO2015/97122, 2015, A1. Location in patent: Page/Page column 102; 103
[2] Patent: WO2014/63068, 2014, A1. Location in patent: Paragraph 00403
[3] Patent: WO2018/42316, 2018, A1. Location in patent: Page/Page column 122
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9663 - 9679
[5] Patent: WO2012/101063, 2012, A1. Location in patent: Page/Page column 98

6-Bromo-5-chloro-2-pyridinamine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

6-Bromo-5-chloro-2-pyridinamine Suppliers

China 85 Germany 1 India 1 United States 11 Global 98

Alfa Chemistry

Tel: +1-5166625404;
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 20405
Advantage: 58

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Aces Pharma, Inc.

Tel: --
Fax: --
Email: sales@acespharma.com
Country: United States
ProdList: 959
Advantage: 50

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynChem，Inc

Tel: --
Fax: --
Email: sales@synchem.com
Country: United States
ProdList: 4697
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

AfferChem, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 278
Advantage: 0

More

Less

View Lastest Price from 6-Bromo-5-chloro-2-pyridinamine manufacturers

Career Henan Chemical Co

Product: 6-Bromo-5-chloro-2-pyridinamine 1004294-58-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-03

1004294-58-9, 6-Bromo-5-chloro-2-pyridinamineRelated Search:

5-Amino-2-bromopyridine 5-BROMO-2-HYDROXY-4-METHYLPYRIDINE 6-Bromo-2-chloro-3-iodopyridine 2-Amino-3-bromo-5-nitropyridine 3-Bromo-5-methylpyridine-2-carboxylic acid 2-bromo-3-chloro-5-fluoropyridine 5-BROMO-2-METHOXY-3-NITRO-PYRIDINE 3-Bromo-6-chloro-2-methylpyridine 2,3-Dibromo-5-chloropyridine 3-BROMO-5-NITROPYRIDINE 3-BROMO-2,5-DICHLOROPYRIDINE 5-bromo-3-methylpicolinonitrile 2,5-Dibromo-3-nitropyridine 2,3-Dibromopyridine 2-Chloro-3-bromo-5-methylpyridine 6-BroMo-2-chloro-3-fluoropyridine 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE 3-BROMO-2-HYDROXY-5-METHYLPYRIDINE

6-Bromo-5-chloro-2-pyridinamine

2-Amino-6-bromo-5-chloropyridine

6-BroMo-5-chloropyridin-2-aMine

6-BroMo-5-chloro-pyridin-2-ylaMine

2-PyridinaMine, 6-broMo-5-chloro-

2-Amino-5-chloro-6-bromopyridine

3-Amino-3-fluoropyridine

1004294-58-9