1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

ChemicalBook > CAS DataBase List > 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

Product Name: 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
CAS No.: 147591-46-6
Chemical Name: 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Synonyms: ID 8;CS-989;ID 8; ID8;ID 8 free base;1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol;1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-;1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol ID8;cell,embryonic,dual-specificity,DYRK,ESC,Inhibitor,inhibit,ID 8,Dual specificity tyrosine phosphorylation regulated kinase,stem,regulated,phosphorylation,kinase,tyrosine,ID-8,Dual specificity tyrosine regulated kinase
CBNumber: CB82510019
Molecular Formula: C16H14N2O4
Formula Weight: 298.29
MOL File: 147591-46-6.mol

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1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Property

Melting point:: 266 °C(dec.)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
form: powder
color: yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
WGK Germany: 3
HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I1786
Product name: ID 8
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: I1786
Product name: ID 8
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $379
Updated: 2024/03/01

TCI Chemical

Product number: I1108
Product name: ID 8
Packaging: 10MG
Price: $123
Updated: 2024/03/01

TCI Chemical

Product number: I1108
Product name: ID 8
Packaging: 50MG
Price: $425
Updated: 2024/03/01

Cayman Chemical

Product number: 15222
Product name: ID 8
Purity: ≥98%
Packaging: 5mg
Price: $56
Updated: 2024/03/01

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1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Chemical Properties,Usage,Production

Description

ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2

Uses

ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.

General Description

ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).

Biochem/physiol Actions

ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).

storage

+4°C

References

1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242 2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Suppliers

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1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

ID 8

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol ID8

ID 8; ID8

CS-989

1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol

ID 8 free base

1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-

1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol

cell,embryonic,dual-specificity,DYRK,ESC,Inhibitor,inhibit,ID 8,Dual specificity tyrosine phosphorylation regulated kinase,stem,regulated,phosphorylation,kinase,tyrosine,ID-8,Dual specificity tyrosine regulated kinase

147591-46-6

Inhibitors