ARRY-424704, ARRY-704
- Product Name
- ARRY-424704, ARRY-704
- CAS No.
- 869357-68-6
- Chemical Name
- ARRY-424704, ARRY-704
- Synonyms
- CS-396;ARRY704;AZD8330;ARRY-704;ARRY424704;ARRY-424704;AZD8330 (ARRY704;AZD8330 AZD-8330;AZD8330(ARRY-424704;ARRY-424704, ARRY-704
- CBNumber
- CB82512518
- Molecular Formula
- C16H17FIN3O4
- Formula Weight
- 461.23
- MOL File
- 869357-68-6.mol
ARRY-424704, ARRY-704 Property
- Density
- 1.732
- storage temp.
- Store at -20°C
- solubility
- ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH
- form
- solid
- pka
- 14.31±0.10(Predicted)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 11588
- Product name
- AZD 8330
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 11588
- Product name
- AZD 8330
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $194
- Updated
- 2024/03/01
- Product number
- 11588
- Product name
- AZD 8330
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 11588
- Product name
- AZD 8330
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $1041
- Updated
- 2024/03/01
- Product number
- 474069
- Product name
- AZD 8330
- Packaging
- 100mg
- Price
- $2229
- Updated
- 2021/12/16
ARRY-424704, ARRY-704 Chemical Properties,Usage,Production
Description
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.
Uses
AZD8330 is an orally active and selective MEK inhibitor.
Definition
ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.
target
ERK phosphorylation
References
1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.
ARRY-424704, ARRY-704 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ARRY-424704, ARRY-704 manufacturers
- Product
- ARRY-424704, ARRY-704 869357-68-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- ARRY-424704, ARRY-704 869357-68-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- ARRY-424704, ARRY-704 869357-68-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-21