ChemicalBook > CAS DataBase List > ARRY-424704, ARRY-704

ARRY-424704, ARRY-704

Product Name
ARRY-424704, ARRY-704
CAS No.
869357-68-6
Chemical Name
ARRY-424704, ARRY-704
Synonyms
CS-396;ARRY704;AZD8330;ARRY-704;ARRY424704;ARRY-424704;AZD8330 (ARRY704;AZD8330 AZD-8330;AZD8330(ARRY-424704;ARRY-424704, ARRY-704
CBNumber
CB82512518
Molecular Formula
C16H17FIN3O4
Formula Weight
461.23
MOL File
869357-68-6.mol
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ARRY-424704, ARRY-704 Property

Density 
1.732
storage temp. 
Store at -20°C
solubility 
≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH
form 
solid
pka
14.31±0.10(Predicted)
color 
Off-white to pink
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11588
Product name
AZD 8330
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
11588
Product name
AZD 8330
Purity
≥98%
Packaging
5mg
Price
$194
Updated
2024/03/01
Cayman Chemical
Product number
11588
Product name
AZD 8330
Purity
≥98%
Packaging
10mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
11588
Product name
AZD 8330
Purity
≥98%
Packaging
50mg
Price
$1041
Updated
2024/03/01
Usbiological
Product number
474069
Product name
AZD 8330
Packaging
100mg
Price
$2229
Updated
2021/12/16
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ARRY-424704, ARRY-704 Chemical Properties,Usage,Production

Description

AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.

Uses

AZD8330 is an orally active and selective MEK inhibitor.

Definition

ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

target

ERK phosphorylation

References

1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.

ARRY-424704, ARRY-704 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARRY-424704, ARRY-704 Suppliers

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View Lastest Price from ARRY-424704, ARRY-704 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
ARRY-424704, ARRY-704 869357-68-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Henan Aochuang Chemical Co.,Ltd.
Product
ARRY-424704, ARRY-704 869357-68-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
ARRY-424704, ARRY-704 869357-68-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11

869357-68-6, ARRY-424704, ARRY-704Related Search:

Binimetinib BKM120 (NVP-BKM120, Buparlisib) MLN0905 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid NVP-BVU 972 Tozasertib R428 Nutlin 3a 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide BMS-794833 AZD-4547 5-Aza-2'-deoxycytidine TAK-733 PD 0325901 CAL-101 BEZ235 (NVP-BEZ235, Dactolisib)

  • ARRY-424704, ARRY-704
  • AZD8330
  • 2-(2-Fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  • ARRY424704
  • ARRY-424704
  • ARRY704
  • ARRY-704
  • AZD8330/ARRY-424704/arry-704/AZD8330/AZD-8330
  • ARRY-424704, ARRY-704 AZD8330
  • AZD8330;ARRY-424704; ARRY424704;ARRY704; AZD8330
  • 2-((2-Fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-
  • CS-396
  • AZD8330(ARRY-424704
  • ARRY-424704; ARRY-704; AZD-8330; ARRY424704; ARRY704; AZD 8330
  • 3-Pyridinecarboxamide, 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-
  • ARRY-424704, ARRY-704 ISO 9001：2015 REACH
  • AZD8330 (ARRY704
  • AZD8330 AZD-8330
  • AZD8330, MEK inhibitor
  • 869357-68-6
  • C16H17FIN3O4
  • Inhibitors
  • MAPK