ARRY-424704, ARRY-704

Product Name: ARRY-424704, ARRY-704
CAS No.: 869357-68-6
Chemical Name: ARRY-424704, ARRY-704
Synonyms: CS-396;ARRY704;AZD8330;ARRY-704;ARRY424704;ARRY-424704;AZD8330 (ARRY704;AZD8330 AZD-8330;AZD8330(ARRY-424704;ARRY-424704, ARRY-704
CBNumber: CB82512518
Molecular Formula: C16H17FIN3O4
Formula Weight: 461.23
MOL File: 869357-68-6.mol

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ARRY-424704, ARRY-704 Property

Density: 1.732
storage temp.: Store at -20°C
solubility: ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH
form: solid
pka: 14.31±0.10(Predicted)
color: Off-white to pink

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11588
Product name: AZD 8330
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 11588
Product name: AZD 8330
Purity: ≥98%
Packaging: 5mg
Price: $194
Updated: 2024/03/01

Cayman Chemical

Product number: 11588
Product name: AZD 8330
Purity: ≥98%
Packaging: 10mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 11588
Product name: AZD 8330
Purity: ≥98%
Packaging: 50mg
Price: $1041
Updated: 2024/03/01

Usbiological

Product number: 474069
Product name: AZD 8330
Packaging: 100mg
Price: $2229
Updated: 2021/12/16

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ARRY-424704, ARRY-704 Chemical Properties,Usage,Production

Description

AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC₅₀ = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.

Uses

AZD8330 is an orally active and selective MEK inhibitor.

Definition

ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

target

ERK phosphorylation

References

1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.

ARRY-424704, ARRY-704 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARRY-424704, ARRY-704 Suppliers

China 97 India 1 United Kingdom 2 United States 20 Global 120

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
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AdooQ BioScience, LLC

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Fax: +1 (866) 333-9607
Email: info@adooq.com
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Jinan Mingya Medical Technology Co., Ltd.

Tel: 0531-85828981
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Email: 864598798@qq.com
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CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
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View Lastest Price from ARRY-424704, ARRY-704 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: ARRY-424704, ARRY-704 869357-68-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Henan Aochuang Chemical Co.,Ltd.

Product: ARRY-424704, ARRY-704 869357-68-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: ARRY-424704, ARRY-704 869357-68-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-11

869357-68-6, ARRY-424704, ARRY-704Related Search:

Binimetinib BKM120 (NVP-BKM120, Buparlisib) MLN0905 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid NVP-BVU 972 Tozasertib R428 Nutlin 3a 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide BMS-794833 AZD-4547 5-Aza-2'-deoxycytidine TAK-733 PD 0325901 CAL-101 BEZ235 (NVP-BEZ235, Dactolisib)

ARRY-424704, ARRY-704

AZD8330

2-(2-Fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide

ARRY424704

ARRY-424704

ARRY704

ARRY-704

AZD8330/ARRY-424704/arry-704/AZD8330/AZD-8330

ARRY-424704, ARRY-704 AZD8330

AZD8330;ARRY-424704; ARRY424704;ARRY704; AZD8330

2-((2-Fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-

CS-396

AZD8330(ARRY-424704

ARRY-424704; ARRY-704; AZD-8330; ARRY424704; ARRY704; AZD 8330

3-Pyridinecarboxamide, 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-

ARRY-424704, ARRY-704 ISO 9001：2015 REACH

AZD8330 (ARRY704

AZD8330 AZD-8330

AZD8330, MEK inhibitor

869357-68-6

C16H17FIN3O4

Inhibitors

MAPK