Amg 517

ChemicalBook > CAS DataBase List > Amg 517

Product Name: Amg 517
CAS No.: 659730-32-2
Chemical Name: Amg 517
Synonyms: CS-691;AM -517;Amg 517;AMG517; AMG-517;AMG 517, 10 mM in DMSO;N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide;AcetaMide, N-[4-[[6-[4-(trifluoroMethyl)phenyl]-4-pyriMidinyl]oxy]-2-benzothiazolyl]-;N-(4-((6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-yl)oxy)benzo[d]thiazol-2-yl)acetamide;N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide AMG517
CBNumber: CB82516228
Molecular Formula: C20H13F3N4O2S
Formula Weight: 430.4
MOL File: 659730-32-2.mol

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Amg 517 Property

Melting point:: 227℃
Density: 1.458
storage temp.: Store at -20°C
solubility: ≥21.5 mg/mL in DMSO; insoluble in H2O; ≥4.93 mg/mL in EtOH
form: solid
pka: 10.19±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26191
Product name: AMG 517
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 26191
Product name: AMG 517
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 26191
Product name: AMG 517
Packaging: 25mg
Price: $268
Updated: 2024/03/01

Cayman Chemical

Product number: 26191
Product name: AMG 517
Packaging: 50mg
Price: $469
Updated: 2024/03/01

Tocris

Product number: 5995
Product name: AMG517
Purity: ≥98%(HPLC)
Packaging: 50
Price: $810
Updated: 2021/12/16

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Amg 517 Chemical Properties,Usage,Production

Uses

AMG-517 is a novel TRPV1 antagonist.

Biological Activity

AMG517 is an orally active, highly potent and selective vanilloid receptor-1 (TRPV1; VR1; capsaicin receptor) antagonist th at blocks TRPV1-mediated cellular Ca2+ influx (h/r/m IC50/stimulant = 0.76 nM/1.01 nM/1.9 nM/500 nM capsaicin; 0.62 nM/0.5 nM/0.63 nM/acid (pH 5) using respective CHO transfectants; IC50 >20 μM against TRPV2/3/4, TRPA1, and TRPM8-mediated responses; <45% binding at 10 μM to 87 receptors, enzymes, and ion channels) and exhibits antihyperalgesic efficacy in vivo (capsaicin-induced flinch = ED50 = 0.33 mg/kg rats, p.o.; CFA-induced thermal hyperalgesia, MED = 0.83 mg/kg rats, p.o.).

storage

Store at +4°C

Amg 517 Preparation Products And Raw materials

Raw materials

Preparation Products

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Amg 517

N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide

AcetaMide, N-[4-[[6-[4-(trifluoroMethyl)phenyl]-4-pyriMidinyl]oxy]-2-benzothiazolyl]-

N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide AMG517

N-(4-((6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-yl)oxy)benzo[d]thiazol-2-yl)acetamide

AMG517; AMG-517

CS-691

AM -517

AMG 517, 10 mM in DMSO

659730-32-2

C20H13F3N4O2S

Inhibitors

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