4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
- Product Name
- 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
- CAS No.
- 104561-41-3
- Chemical Name
- 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
- Synonyms
- EC 23;BASF-46928;EC23, 10 mM in DMSO;OQVLOWLEEHYBJH-UHFFFAOYSA-N;EC-23, photostable synthetic retinoid;Inhibitor,EC-23,BASF 46928,EC23,EC 23,AGN-190205,BASF46928,AGN190205,inhibit;4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid;4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid;Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]-
- CBNumber
- CB82518772
- Molecular Formula
- C23H24O2
- Formula Weight
- 332.44
- MOL File
- 104561-41-3.mol
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Property
- Melting point:
- 254-256 °C(Solv: acetonitrile (75-05-8))
- Boiling point:
- 484.7±45.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
- form
- White to off-white lyophilised amorphous solid.
- pka
- 4.10±0.10(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML2404
- Product name
- EC23
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $69
- Updated
- 2024/03/01
- Product number
- SML2404
- Product name
- EC23
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $279
- Updated
- 2024/03/01
- Product number
- 9002073
- Product name
- EC 23
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 9002073
- Product name
- EC 23
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 9002073
- Product name
- EC 23
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Chemical Properties,Usage,Production
Uses
EC 23 is an ATRA analog with similar activity. EC 23 potently induces neural differentiation in human pluripotent embryonic stem cells.
Biological Activity
EC23 is a synthetic, photostable all-trans retinoic acid (ATRA) analog/mimetic th at targets RAR with greater affinity than ATRA (RARα/β/γ EC50 by cell-free TR-FRET binding assay = 3.7/3.3/16.8 with EC23 vs. 16.0/17.6/14.7 nM with ATRA) and does not bind retinoid x receptors (RXRs). EC23 induces differentiation of human pluripotent embryonic stem cells (0.1-10 μM) with a similar or better efficiency than ATRA.
storage
+4°C
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Preparation Products And Raw materials
Raw materials
Preparation Products
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid Suppliers
- Tel
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- Fax
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- customerservice@tocris.co.uk
- Country
- United Kingdom
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