2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

ChemicalBook > CAS DataBase List > 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

Product Name: 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
CAS No.: 113906-27-7
Chemical Name: 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
Synonyms: CS-2563;PNU 74654;PNU74654; PNU 74654;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
CBNumber: CB82518792
Molecular Formula: C19H16N2O3
Formula Weight: 320.34
MOL File: 113906-27-7.mol

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2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Property

Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
pka: 12.12±0.46(Predicted)
form: solid
color: white to off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0052
Product name: PNU-74654
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: P0052
Product name: PNU-74654
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $557
Updated: 2024/03/01

Cayman Chemical

Product number: 16349
Product name: PNU 74654
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 16349
Product name: PNU 74654
Purity: ≥98%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 16349
Product name: PNU 74654
Purity: ≥98%
Packaging: 10mg
Price: $120
Updated: 2024/03/01

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2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Chemical Properties,Usage,Production

Description

PNU 75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50?= 450 nM) between β-catenin and T cell factor 4 (Tcf4).

Uses

PNU 74654 is a β-catenin inhibitor which inhibits interactions between β-catenin and transcription factor T-cell factor 4 (Tcf4) thus disrupting the Wnt signal transduction pathway.

Uses

PNU-74654 has been used:

as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos
as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines
as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells

Biochem/physiol Actions

PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.

storage

+4°C

References

1) Trosset?et al. (2006)?Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening; Proteins,?64?60

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Suppliers

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2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

PNU 74654

Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide

PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

PNU74654; PNU 74654

CS-2563

N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide

113906-27-7