ChemicalBook > CAS DataBase List > 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

Product Name
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
CAS No.
113906-27-7
Chemical Name
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
Synonyms
CS-2563;PNU 74654;PNU74654; PNU 74654;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
CBNumber
CB82518792
Molecular Formula
C19H16N2O3
Formula Weight
320.34
MOL File
113906-27-7.mol
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2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Property

Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
pka
12.12±0.46(Predicted)
form 
solid
color 
white to off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0052
Product name
PNU-74654
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$142
Updated
2024/03/01
Sigma-Aldrich
Product number
P0052
Product name
PNU-74654
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$557
Updated
2024/03/01
Cayman Chemical
Product number
16349
Product name
PNU 74654
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
16349
Product name
PNU 74654
Purity
≥98%
Packaging
5mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
16349
Product name
PNU 74654
Purity
≥98%
Packaging
10mg
Price
$120
Updated
2024/03/01
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2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Chemical Properties,Usage,Production

Description

PNU 75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50?= 450 nM) between β-catenin and T cell factor 4 (Tcf4).

Uses

PNU 74654 is a β-catenin inhibitor which inhibits interactions between β-catenin and transcription factor T-cell factor 4 (Tcf4) thus disrupting the Wnt signal transduction pathway.

Uses

PNU-74654 has been used:

  • as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos
  • as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines
  • as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells

Biochem/physiol Actions

PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.

storage

+4°C

References

1) Trosset?et al. (2006)?Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening; Proteins,?64?60

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Suppliers

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113906-27-7, 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazideRelated Search:


  • 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
  • PNU 74654
  • Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide
  • PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
  • PNU74654; PNU 74654
  • CS-2563
  • N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide
  • N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide
  • 113906-27-7