2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
- Product Name
- 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
- CAS No.
- 113906-27-7
- Chemical Name
- 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
- Synonyms
- CS-2563;PNU 74654;PNU74654; PNU 74654;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
- CBNumber
- CB82518792
- Molecular Formula
- C19H16N2O3
- Formula Weight
- 320.34
- MOL File
- 113906-27-7.mol
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Property
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- pka
- 12.12±0.46(Predicted)
- form
- solid
- color
- white to off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P0052
- Product name
- PNU-74654
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- P0052
- Product name
- PNU-74654
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $557
- Updated
- 2024/03/01
- Product number
- 16349
- Product name
- PNU 74654
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 16349
- Product name
- PNU 74654
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 16349
- Product name
- PNU 74654
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Chemical Properties,Usage,Production
Description
PNU 75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50?= 450 nM) between β-catenin and T cell factor 4 (Tcf4).
Uses
PNU 74654 is a β-catenin inhibitor which inhibits interactions between β-catenin and transcription factor T-cell factor 4 (Tcf4) thus disrupting the Wnt signal transduction pathway.
Uses
PNU-74654 has been used:
- as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos
- as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines
- as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells
Biochem/physiol Actions
PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.
storage
+4°C
References
1) Trosset?et al. (2006)?Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening; Proteins,?64?60
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Suppliers
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- India
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