SGI-1776

Product Name: SGI-1776
CAS No.: 1025065-69-3
Chemical Name: SGI-1776
Synonyms: CS-504;I-1776;SGI-1776;S I-1776;SGI-1776, >=98%;SGI-1776;SGI1776;I-1776 free base;SGI-1776 free base;SGI-1776 USP/EP/BP;Pim-Kinase Inhibitor IX
CBNumber: CB82561495
Molecular Formula: C20H22F3N5O
Formula Weight: 405.42
MOL File: 1025065-69-3.mol

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SGI-1776 Property

Density: 1.37
storage temp.: Store at -20°C
solubility: ≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH
pka: 9.22±0.10(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16423
Product name: SGI-1776
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16423
Product name: SGI-1776
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 16423
Product name: SGI-1776
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 16423
Product name: SGI-1776
Purity: ≥98%
Packaging: 50mg
Price: $759
Updated: 2024/03/01

Usbiological

Product number: 474186
Product name: SGI-1776
Packaging: 100mg
Price: $1677
Updated: 2021/12/16

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SGI-1776 Chemical Properties,Usage,Production

Uses

A novel, ATP competitive inhibitor of Pim1, Pim2 and Pim3 with IC50s of 7 nM, 363 nM and 69 nM, respectively.

Uses

SGI-1776 is a Pim-1 kinase inhibitor. Potent PIM inhibitor.

Definition

ChEBI: N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-6-imidazo[1,2-b]pyridazinamine is a member of imidazoles.

Biological Activity

sgi-1776 free base, n-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent atp-competitive inhibitor of the serine/threonine family of pim kinase, an enzyme regulating cell survival. through extensive biomedical characterization, sgi-1776 exhibits specificity to the three isoforms of the pim family, including pim-1, pim-2, and pim-3. according to preliminary results from studies treating prostate cancer cells, sgi-1776 dose-dependently reduces phosphorylation of known pim kinase substrates involved in cell cycle progression and apotosis (p21cip1/waf1 and bad), compromises overall cell viability by inducing g1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (mdr1) protein based taxane-refractory prostate cancer cell line.shannon m. mumenthaler, patricia y.b. ng, amanda hodge, davide bearss, gregory berk, sarath kanekal, sanjeev redkar, pietro taverna, davide b. agus, and anjali jain. pharmacological inhibition of pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. mol cancer ther. 2009; 8(10): 2882-2893lisa s. chen, s anjeev redkar, david bearss, william g. wierda and varsha gandhi. pim kinase inhibitor, sgi-1776, induces apoptosis in cll lymphocytes. blood. 2009; 114(19): 4150-4157

target

Pim1

SGI-1776 Preparation Products And Raw materials

Raw materials

Preparation Products

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SGI-1776 Suppliers

China 126 India 2 United Kingdom 1 United States 21 Global 150

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
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ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
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Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
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Aladdin Scientific

Tel: +1-+1(833)-552-7181
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TargetMol Chemicals Inc.

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ApexBio Technology

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Alfa Chemistry

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BOC Sciences

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EBRATOR BIOCHEMICALS,INC.

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Abcam

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Cayman Chemical Company

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United States Biological

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Combi-Blocks Inc.

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Axon Medchem LLC

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Matrix Scientific

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Santa Cruz Biotechnology, Inc.

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View Lastest Price from SGI-1776 manufacturers

Career Henan Chemical Co

Product: SGI-1776 1025065-69-3
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

Career Henan Chemical Co

Product: SGI-1776 1025065-69-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-10

1025065-69-3, SGI-1776Related Search:

SGI 7079 SGI-1027 Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro- CX6258(HCL) (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione A-674563 AZD-1208 BEZ235 (NVP-BEZ235, Dactolisib)

N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine

N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine SGI-1776

SGI-1776

SGI-1776 free base

N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine

SGI-1776, >=98%

SGI-1776 free base N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine

SGI-1776 FREE BASE;SGI1776

N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-am

SGI-1776 free base1025065-69-3

SGI-1776;SGI1776

CS-504

Pim-Kinase Inhibitor IX

I-1776

I-1776 free base

Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-

SGI-1776 USP/EP/BP

S I-1776

SGI-1776, 10 mM in DMSO

1025065-69-3

C20H22F3N5O

Inhibitors

JAK

STAT

Inhibitor

JAK/STAT