WP1130

ChemicalBook > CAS DataBase List > WP1130

Product Name: WP1130
CAS No.: 856243-80-6
Chemical Name: WP1130
Synonyms: WP1130;CS-701;Degrasyn;Degrasyn, >=98%;WP1130 USP/EP/BP;Degrasyn (WP1130);WP1130 ( Degrasyn );WP1130;WP 1130;WP-1130;DEGRASYN; WP 1130; WP-1130;(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
CBNumber: CB82561501
Molecular Formula: C19H18BrN3O
Formula Weight: 384.27
MOL File: 856243-80-6.mol

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WP1130 Property

Density: 1.358
storage temp.: -20°
solubility: Soluble in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml).
form: solid
color: Yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 681685
Product name: WP1130
Purity: A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway.
Packaging: 10MG
Price: $196
Updated: 2024/03/01

Cayman Chemical

Product number: 15227
Product name: WP1130
Purity: ≥95%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15227
Product name: WP1130
Purity: ≥95%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 15227
Product name: WP1130
Purity: ≥95%
Packaging: 25mg
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 15227
Product name: WP1130
Purity: ≥95%
Packaging: 50mg
Price: $535
Updated: 2024/03/01

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WP1130 Chemical Properties,Usage,Production

Description

WP1130 (856243-80-6) is a novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis.1 Blocks Jak2 signaling via Jak2 ubiquitination.2 WP-1130 causes ablation of the oncogenic transcription factor ERG in prostate cancer cells.3 See methyl analog WP1066.

Uses

(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide can be used in biological study of drug screening and proteomic and metabolomic profiling to identify drug action mechanisms of breast cancer impaired pathogenicity.

target

DUB

References

1) Kapuria et al. (2010), Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis; Cancer Res., 70 9265 2) Kapuria et al. (2011), A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination; Cell Signal., 23 2076 3) Wang et al. (2014), Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer; Proc. Natl. Acad. Sci. USA, 111 4251

WP1130 Preparation Products And Raw materials

Raw materials

Preparation Products

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WP1130 Suppliers

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856243-80-6, WP1130Related Search:

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WP1130

(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide

WP1130;WP 1130;WP-1130

CS-701

DEGRASYN; WP 1130; WP-1130

Degrasyn

Degrasyn (WP1130)

WP1130 ( Degrasyn )

(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide

(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide Degrasyn (WP1130)

Degrasyn, >=98%

2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-, (2E)-

WP1130 USP/EP/BP

856243-80-6

Inhibitor

Inhibitors