ChemicalBook > CAS DataBase List > p-Toluenesulfonyl Isocyanate
p-Toluenesulfonyl Isocyanate
- Product Name
- p-Toluenesulfonyl Isocyanate
- CAS No.
- 4083-64-1
- Chemical Name
- p-Toluenesulfonyl Isocyanate
- Synonyms
- PTSI;p-Tosyl isocyanate;P-TOLUENESULPHONYL ISOCYANATE;TOSYL ISOCYANATE;Ptsl;MSI/PTSI;POLYLINK PTSI;PARA-TOSYLISOCYANATE;TOSYL ISOCYANATE (PTSI);Sulfone, isocyanato tolyl
- CBNumber
- CB8256995
- Molecular Formula
- C8H7NO3S
- Formula Weight
- 197.21
- MOL File
- 4083-64-1.mol
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p-Toluenesulfonyl Isocyanate Property
- Melting point:
- 5°C
- Boiling point:
- 144 °C10 mm Hg(lit.)
- Density
- 1.291 g/mL at 25 °C(lit.)
- vapor pressure
- 1 mm Hg ( 100 °C)
- refractive index
- n20/D 1.534(lit.)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Liquid
- color
- Clear colorless to yellow
- Specific Gravity
- 1.291.291
- Odor
- acrid odor
- Water Solubility
- reacts
- Sensitive
- Moisture Sensitive
- BRN
- 391287
- InChIKey
- VLJQDHDVZJXNQL-UHFFFAOYSA-N
- LogP
- 0.6 at 30℃
- CAS DataBase Reference
- 4083-64-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Methylbenzenesulfonyl isocyanate(4083-64-1)
- EPA Substance Registry System
- Benzenesulfonyl isocyanate, 4-methyl- (4083-64-1)
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 14-36/37/38-42
- Safety Statements
- 26-28-30-28A
- RIDADR
- UN 2206 6.1/PG 3
- WGK Germany
- 1
- RTECS
- DB9032000
- F
- 10
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29309090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 189278
- Product name
- p-Toluenesulfonyl isocyanate
- Purity
- 97%
- Packaging
- 25g
- Price
- $43.1
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 189278
- Product name
- p-Toluenesulfonyl isocyanate
- Purity
- 97%
- Packaging
- 100g
- Price
- $45.3
- Updated
- 2024/03/01
TCI Chemical
- Product number
- T0998
- Product name
- p-Toluenesulfonyl Isocyanate
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $18
- Updated
- 2024/03/01
TCI Chemical
- Product number
- T0998
- Product name
- p-Toluenesulfonyl Isocyanate
- Purity
- >97.0%(T)
- Packaging
- 100g
- Price
- $31
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A17492
- Product name
- p-Toluenesulfonyl isocyanate, 95%
- Packaging
- 25g
- Price
- $20.65
- Updated
- 2024/03/01
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p-Toluenesulfonyl Isocyanate Chemical Properties,Usage,Production
Chemical Properties
clear liquid
Uses
It is a reagent used to prepare acetylated syn-1,2-diols,oxazolidin-2-ones, 2,3-diamino acids, and N-tosylcarbonamides. -Toluenesulfonyl isocyanate has been used as derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS. It is also employed in the derivatization reagent in simultaneous quantitative analysis of diethylene glycol and propylene glycol in pharmaceutical products by HPLC and as reagent in the preparation of acetylated syn-1,2-diols, oxazolidin-2-ones, 2,3-diamino acids and N-tosylcarbonamides.
Uses
p-Toluenesulfonyl isocyanate is a reagent used to prepare acetylated syn-1,2-diols,1 oxazolidin-2-ones,2 2,3-diamino acids,3 and N-tosylcarbonamides.4
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 9609, 1994 DOI: 10.1016/0040-4039(94)88523-0
General Description
p-Toluenesulfonyl isocyanate undergoes palladium-catalyzed bis-allylation reaction with allylstannanes and allyl chlorides.
Hazard
Moderately toxic by ingestion. Low toxicity by inhalation. A mild skin and moderate eye irritant.
Synthesis
Add the organic azide (0.75 mmol), Pd(OAc)2
(5.6 mg, 5 mol%) to an oven-dried Schlenk tube (10 mL). Purge the tube
and backfill with CO (three cycles) from a balloon. Inject anhydrous
MeCN (3.0 mL) into the tube. Stir at 80??C for 4 h under CO atmosphere
(balloon). Concentrate the mixture under reduced pressure. Purify the
residue by column chromatography (petroleum ether/EtOAc 3:1.-.1:1).
p-Toluenesulfonyl Isocyanate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from p-Toluenesulfonyl Isocyanate manufacturers
Shaanxi Haibo Biotechnology Co., Ltd
- Product
- p-Toluenesulfonyl Isocyanate 4083-64-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-09-01
airuikechemical co., ltd.
- Product
- Tosyl isocyanate 4083-64-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08
Henan Fengda Chemical Co., Ltd
- Product
- Tosyl isocyanate 4083-64-1
- Price
- US $6.00-0.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-18
4083-64-1, p-Toluenesulfonyl IsocyanateRelated Search:
Chloral hydrate
Sulfosulfuron
Chlorosulfonyl isocyanate
Tosyl cyanide
Dimethyl sulfone
p-Toluenesulfonamide
Sodium p-toluenesulfinate
p-Tolyl isocyanate
P-Toluenesulfonic anhydride
Tosyl chloride
Sodium p-toluenesulfonate
p-Toluenesulfonic acid
p-Toluenesulfonic acid monohydrate
p-Toluenesulfonyl semicarbazide
Tosyl azide
4-Methylbenzenesulfonhydrazide
Ethyl p-toluenesulfonate
Diethyl (tosyloxy)methylphosphonate