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4-(2-Pyridyl)benzoic acid

Product Name
4-(2-Pyridyl)benzoic acid
CAS No.
4385-62-0
Chemical Name
4-(2-Pyridyl)benzoic acid
Synonyms
4-(PYRIDIN-2-YL)BENZOIC ACID;AKOS BAR-0485;RARECHEM AL BE 0861;Atazanavir impurity A;Atazanavir Impurity 11;Pyridinyl Benzoic Acid;Azanavir EP Impurity A;4-(2-pyridinyl)benzoate;Atazanavir EP Impurity A;Atazanavir EP Impurity 7
CBNumber
CB8257154
Molecular Formula
C12H9NO2
Formula Weight
199.21
MOL File
4385-62-0.mol
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4-(2-Pyridyl)benzoic acid Property

Melting point:
236.0 to 240.0 °C
Boiling point:
388.1±25.0 °C(Predicted)
Density 
1.241±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
3.17±0.10(Predicted)
color 
White to Light Grey
CAS DataBase Reference
4385-62-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2455
Product name
4-(2-Pyridyl)benzoic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$102
Updated
2025/07/31
TCI Chemical
Product number
P2455
Product name
4-(2-Pyridyl)benzoic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$353
Updated
2025/07/31
TRC
Product number
P992140
Product name
4-(2-Pyridinyl)benzoicAcid
Packaging
1g
Price
$145
Updated
2021/12/16
Matrix Scientific
Product number
071826
Product name
4-Pyridin-2-yl-benzoic acid
Purity
95+%
Packaging
1g
Price
$85
Updated
2021/12/16
Apolloscientific
Product number
OR912706
Product name
4-(2-Pyridyl)benzoic Acid
Purity
98%
Packaging
1g
Price
$110
Updated
2021/12/16
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4-(2-Pyridyl)benzoic acid Chemical Properties,Usage,Production

Uses

Reactive metabolite of Atazanavir (A790051). Atazanavir Impurity (Pyridinyl Benzoic Acid)

Synthesis

4467-06-5

4385-62-0

Example 10: Synthesis of 4-(2-pyridyl)benzoic acid In a 100 mL jacketed reactor, 200 mL of acetic acid, 0.05 g of manganese(II) acetate, 1.74 g of sulfuric acid, and 3.0 g of 2-(4-methylphenyl)pyridine were sequentially added. The reaction mixture was cooled to 16°C, followed by slow passage of 4.0 g of ozone over 60 minutes. Upon completion of the ozonolysis reaction, the reaction was purged with nitrogen to remove residual ozone from the solvent. The reaction mixture was analyzed by HPLC or GC, which showed that the residue of 2-(4-methylphenyl)pyridine was <0.1% and the yield of 4-(2-pyridyl)benzoic acid was 94-97%.

References

[1] Patent: US2003/216577, 2003, A1. Location in patent: Page/Page column 4
[2] Dyes and Pigments, 2017, vol. 140, p. 269 - 277
[3] Dyes and Pigments, 2011, vol. 91, # 3, p. 413 - 421
[4] Journal of the Chemical Society, 1956, p. 100,101
[5] Patent: US5854264, 1998, A

4-(2-Pyridyl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-Pyridyl)benzoic acid Suppliers

Canada 2 China 107 Germany 4 India 12 Japan 2 Russia 1 The Netherlands 1 United Kingdom 4 United States 21 Global 154
GLR Innovations
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+91 9891111994
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info@glrgroup.in
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India
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TCI Chemicals (India) Pvt. Ltd.
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sales-in@tcichemicals.com
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ProdList
6768
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Chemicea Pharmaceuticals Pvt Ltd
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sales@chemicea.com
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Pharma Affiliates
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SynZeal Research Pvt Ltd
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standards@synzeal.com
Country
India
ProdList
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Pharmaffiliates Analytics and Synthetics P. Ltd
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mktg@pharmaffiliates.com
Country
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A.J Chemicals
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sales@ajchem.in
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View Lastest Price from 4-(2-Pyridyl)benzoic acid manufacturers

Career Henan Chemical Co
Product
4-(2-Pyridyl)benzoic acid 4385-62-0
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

4385-62-0, 4-(2-Pyridyl)benzoic acidRelated Search:

2-Chloro-3-cyanopyridine 4-Aminobenzoic acid Estradiol benzoate Benzoic acid 2-Picolinic acid Anthranilic acid METHYL 4-(5-AMINO-2-PYRIDINYL)BENZENECARBOXYLATE 4-(3'-PYRIDYL)BENZOIC ACID,4-(3-PYRIDYL)BENZOIC ACID,4-(4-PYRIDYL)BENZOIC ACID 3-(2-Pyridyl)benzoic acid 4-(3'-PYRIDYL)BENZOIC ACID,4-(3-PYRIDYL)BENZOIC ACID 3-(3'-PYRIDYL)BENZOIC ACID METHYL 4-(3-FORMYL-2-PYRIDINYL)BENZENECARBOXYLATE METHYL 4-(4-CYANO-2-PYRIDINYL)BENZENECARBOXYLATE METHYL 4-(5-NITRO-2-PYRIDINYL)BENZENECARBOXYLATE 4-(3-Nitropyridin-2-yl)benzoic acid METHYL 4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]BENZENECARBOXYLATE METHYL 4-(6-FORMYLPYRIDIN-2-YL)BENZOATE& METHYL 4-(3-NITRO-2-PYRIDINYL)BENZENECARBOXYLATE

  • RARECHEM AL BE 0861
  • 4-(PYRIDIN-2-YL)BENZOIC ACID
  • 4-(2-PYRIDYL)BENZOIC ACID
  • 4-(2-PYRIDINYL)BENZOIC ACID
  • AKOS BAR-0485
  • 4-Pyridin-2-yl-benzoicacid95%
  • 4-(3-Fluoropyridin-2-yl)benzoic acid
  • 4-(4-Chloropyridin-2-yl)benoic acid
  • 4-(4-Fluoropyridin-2-yl)benzoic acid
  • 4-(5-Fluoropyridin-2-yl)benoic acid
  • Atazanavir iMpurity (Pyridinyl benzoic acid)
  • Benzoic acid, 4-(2-pyridinyl)-
  • Benzoic acid, p-2-pyridyl-
  • 4-(2-pyridinyl)benzoate
  • Atazanavir Impurity 11
  • Pyridinyl Benzoic Acid
  • Atazanavir EP Impurity A
  • Atazanavir Impurity 15 (Pyridinyl Benzoic Acid)
  • Atazanavir impurity A
  • Atazanavir Related Compund D
  • 4-(2-Pyridyl)benzoic acid?New
  • Azanavir EP Impurity A
  • Atazanavir EP Impurity 7
  • 4385-62-0
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • pharmacetical