WP1066

ChemicalBook > CAS DataBase List > WP1066

Product Name: WP1066
CAS No.: 857064-38-1
Chemical Name: WP1066
Synonyms: CS-604;WP1066;WP1066, >=99%;WP1066/WP-1066;WP1066 USP/EP/BP;STAT Inhibitor III;WP1066 (DMSO solution);WP1066; WP 1066;WP-1066;wp1066(STAT Inhibitor III);Stat3 Inhibitor III, WP1066
CBNumber: CB82616030
Molecular Formula: C17H14BrN3O
Formula Weight: 356.22
MOL File: 857064-38-1.mol

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WP1066 Property

Melting point:: 90-93oC
Boiling point:: 569.9±50.0 °C(Predicted)
Density: 1.425
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to at least 25 mg/ml)
form: Off-white solid
pka: 11.00±0.46(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 573097
Product name: STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent.
Packaging: 10mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 14736
Product name: WP1066
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14736
Product name: WP1066
Purity: ≥95%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 14736
Product name: WP1066
Purity: ≥95%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 14736
Product name: WP1066
Purity: ≥95%
Packaging: 25mg
Price: $220
Updated: 2024/03/01

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WP1066 Chemical Properties,Usage,Production

Description

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 μM. It also induces apoptosis in U87-MG (IC₅₀ = 5.6 μM) and U373-MG (IC₅₀ = 3.7 μM) cells. WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats.

Uses

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells.

target

JAK2

References

1) Kong?et al.?(2005),?Discovery of WP1066, a novel Stat3/c-myc inhibitor with potent antitumor activity against human melanoma in vitro and in vivo;?Cancer Res.?65?1387 2) Iwamaru?et al.?(2007),?A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both invitro and in vivo;?Oncogene?26?2435 3) Ferraioli?et al.?(2007),?WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in acute Myelogenous Leukemia Cells;?Cancer Res.?67?11291 4) Kong,?et al.?(2008),?A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells;?Clin. Cancer Res.?14?5759 5) Kong,?et al.?(2009),?A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells;?Cancer Immunol. Immunother.?58?1023 6) Ma,?et al.?(2017),?Stat3 inhibitor abrogates the expression of PD-1 ligands on Lymphoma cell lines;?J. Clin. Exp. Hematop.?57?21

WP1066 Preparation Products And Raw materials

Raw materials

Preparation Products

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WP1066 Suppliers

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View Lastest Price from WP1066 manufacturers

Career Henan Chemical Co

Product: WP1066 857064-38-1
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

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(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide

WP1066, 98%, a novel inhibitor of JAK2 and STAT3

CS-604

WP1066; WP 1066;WP-1066

STAT Inhibitor III

2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-, (2E)-

WP1066 USP/EP/BP

WP-1066 STAT3 Inhibitor III WP1066

WP1066 (DMSO solution)

857064-38-1

C17H14ON3Br

Inhibitors

JAK

STAT

Inhibitor

API