4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Product Name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
CAS No.: 327-78-6
Chemical Name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
Synonyms: 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene;JC0002;Sorafenib INT1;Sorafenib intermediate 3;2-nitro-4-chlorophenylaceticacid;4-chloro-a,a,a-trifluoro-M-tolyl ester;4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate;4-CHLORO-3-TRIFLUROMETHYL)PHENYL ISOCYANATE;3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE;4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE
CBNumber: CB8262374
Molecular Formula: C8H3ClF3NO
Formula Weight: 221.56
MOL File: 327-78-6.mol

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4-Chloro-3-(trifluoromethyl)phenyl isocyanate Property

Melting point:: 40-42 °C(lit.)
Boiling point:: 86-90 °C14 mm Hg(lit.)
Density: 1.4720 (estimate)
vapor pressure: 91Pa at 20℃
Flash point:: 211 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Chloroform, Methanol
form: Low Melting Solid, Powder or Chunks
color: White to yellow
Sensitive: Moisture Sensitive
BRN: 522032
InChI: InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H
InChIKey: AHFPRSSHNSGRCU-UHFFFAOYSA-N
SMILES: C1(Cl)=CC=C(N=C=O)C=C1C(F)(F)F
CAS DataBase Reference: 327-78-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37-36/37/38-42-20/22
Safety Statements: 7-26-27-37/39-36/37/39-45-23
RIDADR: UN 2206 6.1/PG 3
WGK Germany: 3
Hazard Note: Harmful/Moisture Sensitive
HazardClass: 6.1
PackingGroup: III
HS Code: 29291090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 374881
Product name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
Purity: 98%
Packaging: 5g
Price: $16.86
Updated: 2024/03/01

TCI Chemical

Product number: C2778
Product name: 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate
Purity: >98.0%(GC)
Packaging: 5g
Price: $78
Updated: 2024/03/01

TCI Chemical

Product number: C2778
Product name: 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate
Purity: >98.0%(GC)
Packaging: 25g
Price: $248
Updated: 2024/03/01

Alfa Aesar

Product number: L12016
Product name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate, 97%
Packaging: 5g
Price: $80.65
Updated: 2024/03/01

TRC

Product number: C421940
Product name: 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate
Packaging: 5g
Price: $65
Updated: 2021/12/16

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4-Chloro-3-(trifluoromethyl)phenyl isocyanate Chemical Properties,Usage,Production

Chemical Properties

White solid or melt

Uses

4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of: N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea] trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea

Uses

4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of:

N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea
[1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea]
trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea

General Description

4-Chloro-3-(trifluoromethyl)phenyl isocyanate participates in an efficient methodology for the synthesis of 5-methyl-3-aryl-2-thiooxazolidin-4-ones.

Flammability and Explosibility

Non flammable

4-Chloro-3-(trifluoromethyl)phenyl isocyanate Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-3-(trifluoromethyl)phenyl isocyanate Suppliers

Americas 1 Belgium 5 Canada 1 China 374 Europe 1 France 2 Germany 5 India 20 Italy 1 Japan 5 Jordan 1 Poland 1 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 16 United States 34 Global 471

Shanghai Rochi Pharmaceutical Co., Ltd.

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shandong XuanHong Pharmaceutical Technology Co.,Ltd

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ELION INTERNATIONAL(HONGKONG) CO., LTD

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Beijing Jianuode Pharmaceutical Technology Co., Ltd.

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Shandong Shenghe Pharmaceutical Technology Co. LTD

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Lianyungang Shenghe Biotechnology Co., Ltd.

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Jinan Duowei Innovation Biotechnology Co., Ltd

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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
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Country: China
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View Lastest Price from 4-Chloro-3-(trifluoromethyl)phenyl isocyanate manufacturers

Nanjing Fred Technology Co., Ltd

Product: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate 327-78-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-26

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate 327-78-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-09

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate 327-78-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg
Release date: 2022-09-23

327-78-6, 4-Chloro-3-(trifluoromethyl)phenyl isocyanateRelated Search:

Propyl isocyanate 4-Chlorobenzotrifluoride Benzotrifluoride 4-(Chloromethyl)benzoic acid 3-Fluorobenzotrifluoride Vinylbenzyl chloride Phenyl butyrate Chlorosulfonyl isocyanate Diphenyl chlorophosphate Phenyl isothiocyanate PHENYL ACETATE 2-Methylbenzotrifluoride Phenyl chloroformate 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine PHENYL VALERATE Phenylhydrazine Trityl olmesartan Epichlorohydrin

4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE

3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE

4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE 98%

1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene

4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate

4-Chloro-3-(trifluoromethyl)phenyl isocyanate,98%

4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 98% 5GR

Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)-

4-chloro-a,a,a-trifluoro-M-tolyl ester

4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 97.5%

4-Chloro-3-(trifluoroMethoxy)phenyl Isocyanate

Three fluorine chlorine - 4-3 - Methyl phenyl isocyanate

Sorafenib INT1

Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester

4-Chloro-3-(trifluoromethyl)phenyl isocyanate(327-78-6)

4-Chloro-3-(trifluoromethyl)phenyl Isocyanate &gt

4-Chloro-3-(trifluoromethy) phenyl isocyanate

4-CHLORO-3-TRIFLUROMETHYL)PHENYL ISOCYANATE

Phenyl 4- chloro -3- trifluoromethyl isocyanate

Sorafenib intermediate 3

2-nitro-4-chlorophenylaceticacid

JC0002

327-78-6

372-78-6

ClC6H3CF3NCO

ARYL ISOCYANATE

Building Blocks

Organic Building Blocks

Nitrogen Compounds

Isocyanates

Phenyl isocyanate&Phenyl isothiocyanate

Isocyanates

Nitrogen Compounds

Organic Building Blocks