ChemicalBook > CAS DataBase List > PXD-101

PXD-101

Product Name: PXD-101
CAS No.: 866323-14-0
Chemical Name: PXD-101
Synonyms: Belista;Bellista;Belisi He;Belinostat（E）;Belinostat Impurity;Belinostat, 10 mM in DMSO;PXD101;PX105684;PXD-101;PXD 101;PX-105684;3-[3-(phenylsulfamoyl)phenyl]prop-2-enehydroxamic acid;(e)-n-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide;(2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
CBNumber: CB82628305
Molecular Formula: C15H14N2O4S
Formula Weight: 318.35
MOL File: 866323-14-0.mol

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PXD-101 Property

Melting point:: 172 °C(Solv: ethyl acetate (141-78-6))
Density: 1.427±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO:64.0(Max Conc. mg/mL);201.4(Max Conc. mM)
form: powder to crystal
pka: 8.27±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
InChIKey: NCNRHFGMJRPRSK-MDZDMXLPSA-N
SMILES: C(NO)(=O)/C=C/C1=CC=CC(S(NC2=CC=CC=C2)(=O)=O)=C1

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Safety

HS Code: 2935.90.6000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H340May cause genetic defects

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3010
Product name: Belinostat
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $91.48
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3010
Product name: Belinostat
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $392
Updated: 2025/07/31

TCI Chemical

Product number: B5888
Product name: Belinostat
Packaging: 25MG
Price: $64
Updated: 2025/07/31

TCI Chemical

Product number: B5888
Product name: Belinostat
Packaging: 100MG
Price: $176
Updated: 2025/07/31

ChemScene

Product number: CS-0453
Product name: Belinostat
Purity: 99.94%
Packaging: 50mg
Price: $180
Updated: 2021/12/16

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PXD-101 Chemical Properties,Usage,Production

Uses

Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.

Definition

ChEBI: Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. It has a role as an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a hydroxamic acid, a sulfonamide and an olefinic compound.

Biological Activity

Belinost at (PX105684; PXD101) is a potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 41/125/30/216 nM, class IIA HDAC4/7/9 = 115/67/128 nM, class IIB HDAC6 = 82 nM) with anti-cancer efficacy in vitro and in vivo.

in vivo

Treatment of nude mice bearing human ovarian and colon tumor xenografts with Belinostat (10-40 mg/kg/day i.p.) daily for 7 days causes a significant dose-dependent growth delay with no obvious signs of toxicity to the mice. Growth delay is also observed for xenografts of cisplatin-resistant ovarian tumor cells. A marked increase in acetylation of H4 is detected in blood and tumor of mice 3 h after treatment with Belinostat (PXD101). The inhibition of growth of human tumor xenografts in mice, with no apparent toxicity^[1]. Belinostat (PXD101) displays single-agent antitumor activity on human A2780 ovarian cancer s.c. xenografts which is enhanced via combination therapy with Carboplatin^[2].

IC 50

HDAC6: 82 nM (IC₅₀); HDAC: 27 nM (IC₅₀, Hela cell)

References

[1] Plumb JA, et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histonedeacetylase inhibitor PXD101. Mol Cancer Ther. 2003 Aug;2(8):721-8. PMID:12939461
[2] Qian X, et al. Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies. Mol Cancer Ther. 2006 Aug;5(8):2086-95. DOI:10.1158/1535-7163.MCT-06-0111
[3] Chia S, et al. Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time. Nat Commun. 2017 Sep 5;8(1):435. DOI:10.1038/s41467-017-00451-5

PXD-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PXD-101 manufacturers

Moxin Chemicals

Product: Belinostat Impurity 866323-14-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 10000000
Release date: 2025-02-27

Career Henan Chemical Co

Product: PXD-101 866323-14-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 100KG
Release date: 2018-08-20

866323-14-0, PXD-101Related Search:

N-[(2,3-dimethoxyphenyl)methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride 2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)- Belinostat (PXD101) Bambuterol CETUXIMAB Rituximab Chidamide

(2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide

2-PropenaMide, N-hydroxy-3-[3-[(phenylaMino)sulfonyl]phenyl]-, (2E)-

Belista

PXD101;PX105684;PXD-101;PXD 101;PX-105684

Belinostat（E）

3-[3-(phenylsulfamoyl)phenyl]prop-2-enehydroxamic acid

(e)-n-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide

Belinostat Impurity

Bellista

Belinostat, 10 mM in DMSO

Belisi He

866323-14-0