Methyl 3-broMo-4-forMylbenzoate
- Product Name
- Methyl 3-broMo-4-forMylbenzoate
- CAS No.
- 90484-53-0
- Chemical Name
- Methyl 3-broMo-4-forMylbenzoate
- Synonyms
- ethyl 3-broMo-4-forMylbenzoate;Methyl 3-broMo-4-forMylbenzoate;3-Bromo-4-formyl-benzoic acid methyl ester;Benzoic acid, 3-bromo-4-formyl-, methyl ester
- CBNumber
- CB82657387
- Molecular Formula
- C9H7BrO3
- Formula Weight
- 243.05
- MOL File
- 90484-53-0.mol
Methyl 3-broMo-4-forMylbenzoate Property
- Melting point:
- 76.8-77.6℃
- Boiling point:
- 326.0±27.0 °C(Predicted)
- Density
- 1.566±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- crystalline solid
- color
- Off-white/faint yellow
- InChI
- InChI=1S/C9H7BrO3/c1-13-9(12)6-2-3-7(5-11)8(10)4-6/h2-5H,1H3
- InChIKey
- OILDTPUIIUEPFL-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(C=O)C(Br)=C1
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M293805
- Product name
- Methyl3-bromo-4-formylbenzoate
- Packaging
- 250mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 2623-9-46
- Product name
- Methyl 3-bromo-4-formylbenzoate
- Packaging
- 1g
- Price
- $440
- Updated
- 2021/12/16
- Product number
- HCH0369282
- Product name
- METHYL-3-BROMO-4-FORMYLBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.31
- Updated
- 2021/12/16
- Product number
- 5064AC
- Product name
- Methyl3-bromo-4-formylbenzoate
- Packaging
- 5g
- Price
- $594
- Updated
- 2021/12/16
- Product number
- 5064AC
- Product name
- Methyl3-bromo-4-formylbenzoate
- Packaging
- 100mg
- Price
- $96
- Updated
- 2021/12/16
Methyl 3-broMo-4-forMylbenzoate Chemical Properties,Usage,Production
Synthesis
1001200-40-3
90484-53-0
General procedure for the synthesis of methyl 3-bromo-4-(dibromomethyl)benzoate from methyl 3-bromo-4-(dibromomethyl)benzoate: To a solution of methyl 3-bromo-4-(dibromomethyl)benzoate (32.0 g, 65.3 mmol) in acetone (400 mL) was added silver nitrate (33.3 g, 196 mmol) and water (100 mL). The reaction mixture was stirred at room temperature for 1 hour away from light. Upon completion of the reaction, the resulting silver salt was removed by filtration and the filtrate was diluted with ethyl acetate and washed sequentially with brine, saturated sodium bicarbonate solution and water. The organic layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure and purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 0-20% gradient) to afford methyl 3-bromo-4-formylbenzoate (12.9 g, 52.0 mmol, 80% yield) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and LC/MS: 1H NMR δ 10.26 (s, 1H), 8.23 (s, 1H), 8.08 (d, J = 8.1 Hz, 1H), 7.97 (d, J = 8.0 Hz, 1H), 3.91 (s, 3H); LC/MS (m/z) ES: 243 ( M+1).
References
[1] Tetrahedron, 2008, vol. 64, # 4, p. 688 - 695
[2] Patent: WO2017/2078, 2017, A1. Location in patent: Page/Page column 37; 38
[3] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
[4] Patent: WO2013/149997, 2013, A1. Location in patent: Page/Page column 50; 51
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 7, p. 854 - 881
Methyl 3-broMo-4-forMylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 3-broMo-4-forMylbenzoate manufacturers
- Product
- ethyl 3-broMo-4-forMylbenzoate 90484-53-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12