ChemicalBook > CAS DataBase List > (2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Product Name
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
CAS No.
1147350-75-1
Chemical Name
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
Synonyms
Clopidogrel Impurity 57;Clopidogrel thiolactone;2S-Oxo Clopidogrel Hydrochloride;2-OXO-CLOPIDOGREL; CLOPIDOGREL THIOLACTONE; 2-OXOCLOPIDOGREL;Methyl (αS)-α-(2-Chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate;Methyl (2S)-2-(2-chlorophenyl)-2-(2-oxo-4,6,7,7a-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate;(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate;methyl (2S)-2-(2-chlorophenyl)-2-(2-oxo-2,6,7,7a-tetrahydrothieno[3,2-c]pyridin-5(4H)-yl)acetate;Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxo-, methyl ester, (αS)-
CBNumber
CB82660871
Molecular Formula
C16H16ClNO3S
Formula Weight
337.82
MOL File
1147350-75-1.mol
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(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate Property

Boiling point:
488.1±45.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 50 mg/mL (148.01 mM); Water: < 0.1 mg/mL (insoluble)
form 
Solid
pka
3.41±0.20(Predicted)
color 
Brown to reddish brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-4888
Product name
Clopidogrelthiolactone
Purity
>98.0%
Packaging
5mg
Price
$360
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611740
Product name
Clopidogrel thiolactone
Packaging
50mg
Price
$765
Updated
2021/12/16
ChemScene
Product number
CS-4888
Product name
Clopidogrelthiolactone
Purity
>98.0%
Packaging
50mg
Price
$1080
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611740
Product name
Clopidogrel thiolactone
Packaging
100mg
Price
$1431.4
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0032549
Product name
(2S)-METHYL 2-(2-CHLOROPHENYL)-2-(2-OXO-7,7ALPHA-DIHYDROTHIENO[3,2-C]PYRIDIN-5(2H,4H,6H)-YL)ACETATE
Purity
95.00%
Packaging
5MG
Price
$500.18
Updated
2021/12/16
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(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate Chemical Properties,Usage,Production

Uses

Methyl (αS)-α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate is the essential intermediate metabolite from which the active metabolite of Clopidogel is formed.

in vivo

Clopidogrel thiolactone (8 μm/kg; i.v.) has good biological availability and pharmacokinetic parameters in Sprague-Dawley male rats[1].

Animal Model:Sprague-Dawley male rats[1]
Dosage:8 μm/kg; with orally clopidogrel (24 μm/kg)
Administration:Intravenous injection; collected blood at 0 h (before dosing) and 0.083, 0.167, 0.5, 1, 2, 4, 6, 8, 24 h postdose.
Result:1.19

IC 50

P2Y12 Receptor

(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate Suppliers

China 50 United States 7 Global 57
BOC Sciences
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United States
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Shanghai Changyan Chem & Tech Co., Ltd.
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd
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View Lastest Price from (2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate manufacturers

Career Henan Chemical Co
Product
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate 1147350-75-1
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g； 1kg; 25kg
Release date
2020-01-10

1147350-75-1, (2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetateRelated Search:

Methylamine hydrochloride Betaine hydrochloride Dimethylamine hydrochloride Clopidogrel hydrogen sulfate

  • (2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
  • Clopidogrel thiolactone
  • Clopidogrel Impurity 57
  • 2-OXO-CLOPIDOGREL; CLOPIDOGREL THIOLACTONE; 2-OXOCLOPIDOGREL
  • 2S-Oxo Clopidogrel Hydrochloride
  • Methyl (2S)-2-(2-chlorophenyl)-2-(2-oxo-4,6,7,7a-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate
  • Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxo-, methyl ester, (αS)-
  • Methyl (αS)-α-(2-Chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate
  • methyl (2S)-2-(2-chlorophenyl)-2-(2-oxo-2,6,7,7a-tetrahydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
  • 1147350-75-1