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S-Ruxolitinib (INCB018424)

Product Name
S-Ruxolitinib (INCB018424)
CAS No.
941685-37-6
Chemical Name
S-Ruxolitinib (INCB018424)
Synonyms
CS-1401;INCB 18424;S-INCB18424;S-Ruxolitinib;Ruxolitinib Impurity A;S-Ruxolitinib (INCB018424);Ruxolitinib (S enantioMer);RUXOLITINIB S ENANTIOMER;INCB18424;S-Ruxolitinib INCB018424 INCB-018424;Ruxolitinib Impurity 1（(S)-Ruxolitinib）
CBNumber
CB82665159
Molecular Formula
C17H18N6
Formula Weight
306.36
MOL File
941685-37-6.mol
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S-Ruxolitinib (INCB018424) Property

Melting point:
138-143oC
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
11.63±0.50(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C988940
Product name
(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile(ent-Ruxolitinib)
Packaging
100mg
Price
$1465
Updated
2021/12/16
Biorbyt Ltd
Product number
orb154739
Product name
S-Ruxolitinib (INCB018424)
Purity
>98%
Packaging
1g
Price
$1802
Updated
2021/12/16
ChemScene
Product number
CS-2768
Product name
Ruxolitinib(Senantiomer)
Purity
99.92%
Packaging
5mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-2768
Product name
Ruxolitinib(Senantiomer)
Purity
99.92%
Packaging
10mg
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-2768
Product name
Ruxolitinib(Senantiomer)
Purity
99.92%
Packaging
50mg
Price
$144
Updated
2021/12/16
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S-Ruxolitinib (INCB018424) Chemical Properties,Usage,Production

Uses

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. The opposite enantiomer of Ruxolitinib (R702000).

Biological Activity

s-ruxolitinib is the chirality of incb018424, is a potent and selective small-molecule janus kinase 1 (jak1) and jak2 inhibitor. it was initially developed to target the constitutive activation of the jak-stat pathway. janus kinases (jaks) are a family of cytoplasmic tyrosine kinases that mediates signals from the receptors for various cytokines and growth factors that have a key role in haematopoiesis and immune function. ruxolitinib maintains its anti-jak activity by competitive inhibition of the atp-binding catalytic site of the kinase domain. ruxolitinib is well absorbed at >95%. exposure of jak2v617f-positive ba/f3 cells to ruxolitinib iss shown to result in reduced cellular proliferation.ruben a. mesa, uma yasothan, peter kirkpatrick. ruxolitinib. nature reviews drug discovery. 2012; 11: 103-104john mascarenhas, ronald hoffman. ruxolitinib: the first fda approved therapy for the treatment of myelofibrosis. clinical cancer research. 2012; 18(11): 3008 - 3014

target

JAK1

S-Ruxolitinib (INCB018424) Preparation Products And Raw materials

Raw materials

Preparation Products

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S-Ruxolitinib (INCB018424) Suppliers

Canada 1 China 95 India 2 United States 14 Global 112
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from S-Ruxolitinib (INCB018424) manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
(S)-Ruxolitinib 941685-37-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-06
Career Henan Chemical Co
Product
S-Ruxolitinib(INCB018424) 941685-37-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
g/kg/T
Release date
2019-12-18

941685-37-6, S-Ruxolitinib (INCB018424)Related Search:

Ruxolitinib phosphate 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Ruxolitinib 1H-Pyrazole-1-propanenitrile, 4-(6-amino-5-formyl-4-pyrimidinyl)-β-cyclopentyl-, (βR)- Cabozantinib Zanubrutinib Lapatinib Erlotinib Sunitinib Dasatinib LOXO-292 Tofacitinib Selonsertib Bortezomib ABT-199 Linsitinib VE 822 GDC-0879

  • S-Ruxolitinib (INCB018424)
  • S-Ruxolitinib
  • INCB 18424
  • 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-
  • Ruxolitinib (S enantioMer)
  • (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
  • RUXOLITINIB S ENANTIOMER;INCB18424
  • (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (ent-Ruxolitinib)
  • CS-1401
  • Ruxolitinib Impurity 1（(S)-Ruxolitinib）
  • (S)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
  • Ruxolitinib Impurity A
  • "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile"Q: What is "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile" Q: What is the CAS Number of "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile" Q: What is the storage condition of "(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile"
  • S-Ruxolitinib INCB018424 INCB-018424
  • S-INCB18424
  • Ruxolitinib Impurity A (Ruxolitinib Enantiomer)
  • 941685-37-6
  • Inhibitor
  • Inhibitors
  • Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
  • JAK
  • STAT