2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide
- Product Name
- 2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide
- CAS No.
- 587841-73-4
- Chemical Name
- 2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide
- Synonyms
- 278;CS-912;ZCL 278;NSC 42964;ZCL278, >95%;ZCL278, >=98%;ZCL278; ZCL-278;CDC42 Inhibitor III, ZCL278 - CAS 587841-73-4 - Calbiochem;2-(4-Bromo-2-chlorophenoxy)-N-((4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)carbAmothioy;2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide
- CBNumber
- CB82668761
- Molecular Formula
- C21H19BrClN5O4S2
- Formula Weight
- 584.89
- MOL File
- 587841-73-4.mol
2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide Property
- storage temp.
- +2C to +8C
- solubility
- ≥29.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- Light beige solid
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 5.00503
- Product name
- CDC42 Inhibitor III, ZCL278 - CAS 587841-73-4 - Calbiochem
- Packaging
- 25MG
- Price
- $252
- Updated
- 2024/03/01
- Product number
- 14849
- Product name
- ZCL 278
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $47
- Updated
- 2024/03/01
- Product number
- 14849
- Product name
- ZCL 278
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 14849
- Product name
- ZCL 278
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 14849
- Product name
- ZCL 278
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $160
- Updated
- 2024/03/01
2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide Chemical Properties,Usage,Production
Uses
ZCL 278, is a selective inhibitor of Cdc42, and effectively inhibits EGF-stimulated Cdc42 activity including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons.
Biological Activity
zcl278 is a selective inhibitor of cdc42 with kd value of 11.4 μm [1].cell division control protein 42 homolog (cdc42) is a small gtpase that belongs to the rho family and plays an important role in regulating diverse cellular functions including cell morphology, endocytosis, migration, and cell cycle progression [2].zcl278 is a potent cdc42 inhibitor and has a different selectivity with the reported cdc42 inhibitor ml141. when tested with human metastatic prostate cancer pc-3 cells, zcl278 showed inhibitory function on rac/cdc42 phosphorylation and the function increasing as the more-treated time. in cortical neurons, zcl278 treatment suppressed neuronal branch number and inhibited growth cone motility at the dose of 50 μm for 5 or 10 min. treated serum-starved swiss 3t3 fibroblasts cdc42 activator following administration of zcl278 at the dose of 50 μm for 1 h exhibited a significant decrease (nearly 80%) in gtp-cdc42 and disrupted perinuclear distribution of active cdc42. [1]. when tested with rat cerebellar granule neurons (cgns), pre-treated with zcl278 before exposed to naaso2 increased cell viability in a dose-dependent manner (20, 50 and 100μm) [3].
References
[1]. friesland, a., et al., small molecule targeting cdc42-intersectin interaction disrupts golgi organization and suppresses cell motility. proc natl acad sci u s a, 2013. 110(4): p. 1261-6.
[2]. selamat, w., et al., the cdc42 effector kinase pak4 localizes to cell-cell junctions and contributes to establishing cell polarity. plos one, 2015. 10(6): p. e0129634.
[3]. liu, x., et al., neuroglobin plays a protective role in arsenite-induced cytotoxicity by inhibition of cdc42 and rac1gtpases in rat cerebellar granule neurons. cell physiol biochem, 2015. 36(4): p. 1613-1627.
2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide manufacturers
- Product
- 2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide 587841-73-4
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03