ChemicalBook > CAS DataBase List > ADIPORON

ADIPORON

Product Name
ADIPORON
CAS No.
924416-43-3
Chemical Name
ADIPORON
Synonyms
CS-918;104890;AdipiRon;AdipoRon;SC-396658;AdipoR agonist;AdipoRon (SC-396658);924416-43-3, CFCD924416433,;AdipoRon, Adiponectin receptor agonist;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide
CBNumber
CB82681793
Molecular Formula
C27H28N2O3
Formula Weight
428.52
MOL File
924416-43-3.mol
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ADIPORON Property

Melting point:
106-108°C
Boiling point:
645.3±55.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
13.92±0.20(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0998
Product name
AdipoRon
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0998
Product name
AdipoRon
Purity
≥98% (HPLC)
Packaging
25mg
Price
$476
Updated
2024/03/01
Cayman Chemical
Product number
15941
Product name
AdipoRon
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
15941
Product name
AdipoRon
Purity
≥98%
Packaging
10mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
15941
Product name
AdipoRon
Purity
≥98%
Packaging
25mg
Price
$161
Updated
2024/03/01
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ADIPORON Chemical Properties,Usage,Production

Description

Adiponectin expressed by adipocytes exerts antidiabetic effects by binding to adiponectin receptor (AdipoR)1, which activates AMPK pathways, and AdipoR2, which activates PPARα pathways. AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with KD values of 1.8 and 3.1 μM, respectively. At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin resistance and glucose intolerance in wild type mice fed a high-fat diet and in genetically obese db/db mice.

Uses

AdipoRon is an AdipoR agonist and activates AMPK and PPAR-α pathways in the muscle and liver. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes.

Biochem/physiol Actions

AdipoRon is an adiponectin agonist that binds to and activates adiponectin receptors AdipoR1 and AdipoR2, activating AMPK and PPAR-α pathways, and ameliorating insulin resistance and glucose intolerance in mice fed a high-fat diet in a manner similar to adiponectin itself. AdipoRon did not affect body weight, but did increase the expression of genes involved in fatty-acid oxidation, decreased tissue triglyceride content, and prolonged the shortened lifespan of db/db mice.

storage

+4°C

References

1) Okada-Iwabu?et al. (2013),?A small-molecule AdipoR agonist for type 2 diabetes and short life obesity; Nature 503?493 2) Fairaq?et al.?(2017),?AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia; Pharmacol. Res.?119?289

ADIPORON Preparation Products And Raw materials

Raw materials

Preparation Products

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ADIPORON Suppliers

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View Lastest Price from ADIPORON manufacturers

Career Henan Chemical Co
Product
SC-396658;AdipoRon;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide 924416-43-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg; 2kg；10kg; 100kg
Release date
2019-08-30

924416-43-3, ADIPORONRelated Search:

AR-A014418 Fatostatin A A 769662 (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE KI16425 PF-01367338 Veliparib LY 294002 HYDROCHLORIDE 2-Nitroimidazole Olaparib

  • SC-396658
  • AdipoRon
  • 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide
  • 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide
  • 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide AdipoRon
  • AdipoR agonist
  • AdipiRon
  • ACETAMIDE, 2-(4-BENZOYLPHENOXY)-N-[1-(PHENYLMETHYL)-4-PIPERIDINYL]-
  • 104890
  • CS-918
  • 924416-43-3, CFCD924416433,
  • AdipoRon (SC-396658)
  • AdipoRon, Adiponectin receptor agonist
  • 924416-43-3
  • Inhibitors
  • API