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Atglistatin

Product Name
Atglistatin
CAS No.
1469924-27-3
Chemical Name
Atglistatin
Synonyms
istatin;CS-1024;Atglistatin;At listatin;Atglistatin, >=98%;Atglistatin, 10 mM in DMSO;ATGL Inhibitor, Atglistatin;3-(4'-(DIMETHYLAMINO)BIPHENYL-3-YL)-1,1-DIMETHYLUREA;3-[4’-(Dimethylamino)-biphenyl-3-yl]-1,1-dimethylurea;3-[4’-(Dimethylamino)-biphenyl-3-yl]-1,1-dimethylurea
CBNumber
CB82685322
Molecular Formula
C17H21N3O
Formula Weight
283.37
MOL File
1469924-27-3.mol
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Atglistatin Property

Boiling point:
498.6±45.0 °C(Predicted)
Density 
1.135±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
form 
powder
pka
15.01±0.70(Predicted)
color 
white to beige
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
36/37/39
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1075
Product name
Atglistatin
Purity
≥98% (HPLC)
Packaging
5MG
Price
$114.95
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1075
Product name
Atglistatin
Purity
≥98% (HPLC)
Packaging
25MG
Price
$512
Updated
2025/07/31
Sigma-Aldrich
Product number
5.30151
Product name
ATGL Inhibitor, Atglistatin
Packaging
10 mg
Price
$246
Updated
2025/07/31
TCI Chemical
Product number
A3468
Product name
3-[4'-(Dimethylamino)[1,1'-biphenyl]-3-yl]-1,1-dimethylurea
Packaging
10MG
Price
$211
Updated
2025/07/31
Cayman Chemical
Product number
15284
Product name
Atglistatin
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
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Atglistatin Chemical Properties,Usage,Production

Description

Adipose triglyceride lipase (ATGL or PNPLA2) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets, generating diacylglyerol. Atglistatin is a potent, selective, and competitive inhibitor of ATGL (IC50 = 0.7 μM). It does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases. Atglistatin blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in vivo. It does not affect lipolysis in ATGL knockout mice.

Uses

Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).

Biochem/physiol Actions

Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC50 of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.

in vivo

Animals receive Atglistatin dissolved in olive oil by oral gavage. After application, blood and tissues are collected for determination of plasma parameters, tissue Triacylglycerol (TG) levels, and inhibitor concentrations. Time-course experiments revealed that the lipolytic parameters fatty acids (FA) and glycerol are reduced 4 and 8 hours after application and returned to normal after 12 hours. Eight hours after treatment, a dose-dependent decrease is observed in FA and glycerol levels up to 50% and 62%, respectively. Atglistatin also caused a strong reduction in plasma TG levels (-43%) while blood glucose, total cholesterol, ketone bodies, and insulin levels do not significantly change. Dose and time-dependent inhibition of lipolysis is also observed in response to intraperitoneal injection of Atglistatin[1].

References

[1] NICOLE MAYER. Development of small-molecule inhibitors targeting adipose triglyceride lipase[J]. Nature chemical biology, 2013, 9 12: 785-787. DOI:10.1038/nchembio.1359
[2] RACHID ZAGANI. Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells.[J]. Oncotarget, 2015: 28282-28295. DOI:10.18632/oncotarget.5061

Atglistatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Atglistatin Suppliers

China 147 India 1 United Kingdom 1 United States 19 Global 168
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
998
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
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View Lastest Price from Atglistatin manufacturers

Career Henan Chemical Co
Product
Atglistatin 1469924-27-3
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

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