Atglistatin
- Product Name
- Atglistatin
- CAS No.
- 1469924-27-3
- Chemical Name
- Atglistatin
- Synonyms
- istatin;CS-1024;Atglistatin;Atglistatin, >=98%;3-(4'-(DIMETHYLAMINO)BIPHENYL-3-YL)-1,1-DIMETHYLUREA;3-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea;N'-[4'-(Dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethylurea;3-(4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)-1,1-dimethylurea;3-(4'-(Dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea;Urea, N'-[4'-(dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethyl-
- CBNumber
- CB82685322
- Molecular Formula
- C17H21N3O
- Formula Weight
- 283.37
- MOL File
- 1469924-27-3.mol
Atglistatin Property
- Boiling point:
- 498.6±45.0 °C(Predicted)
- Density
- 1.135±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
- form
- powder
- pka
- 15.01±0.70(Predicted)
- color
- white to beige
- Stability:
- Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1075
- Product name
- Atglistatin
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $115
- Updated
- 2023/06/20
- Product number
- SML1075
- Product name
- Atglistatin
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $486
- Updated
- 2023/06/20
- Product number
- 15284
- Product name
- Atglistatin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 15284
- Product name
- Atglistatin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 15284
- Product name
- Atglistatin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
Atglistatin Chemical Properties,Usage,Production
Description
Adipose triglyceride lipase (ATGL or PNPLA2) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-
Uses
Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).
Biochem/physiol Actions
Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC50 of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.
References
1) Mayer et al. (2013), Development of small-molecule inhibitors targeting adipose triglyceride lipase; Nat. Chem. Biol. 9 785 2) Zagani et al. (2015) Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells; Oncotarget 6 28282
Atglistatin Preparation Products And Raw materials
Raw materials
Preparation Products
Atglistatin Suppliers
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View Lastest Price from Atglistatin manufacturers
- Product
- Atglistatin 1469924-27-3
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03