Dobutamine hydrochloride
- Product Name
- Dobutamine hydrochloride
- CAS No.
- 49745-95-1
- Chemical Name
- Dobutamine hydrochloride
- Synonyms
- DOBUTAMINE HCL;Dobutrex;46236;Dobux;Dopmin;Inotrex;NSC 299583;Dobutamine hydrochlo;Dobutamine hydrochloride;DL-Dobutamine hydrochloride
- CBNumber
- CB8274063
- Molecular Formula
- C18H24ClNO3
- Formula Weight
- 337.84
- MOL File
- 49745-95-1.mol
Dobutamine hydrochloride Property
- Melting point:
- 184-186 C
- storage temp.
- 2-8°C
- solubility
- Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent).
- form
- Solid
- pka
- 9.45(at 25℃)
- color
- White to Off-White
- Water Solubility
- Soluble in water or ethanol with warming. Also soluble in methanol
- λmax
- 281nm(MeOH)(lit.)
- Merck
- 14,3395
- Stability:
- Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light.
- CAS DataBase Reference
- 49745-95-1(CAS DataBase Reference)
- EPA Substance Registry System
- 1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-63-36/37/38-R63-R62-R11-R21-R20
- Safety Statements
- 22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22
- WGK Germany
- 3
- HS Code
- 29222990
- Toxicity
- LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D0676
- Product name
- Dobutamine hydrochloride
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $84.7
- Updated
- 2024/03/01
- Product number
- BP674
- Product name
- Dobutamine hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $223
- Updated
- 2024/03/01
- Product number
- 1224507
- Product name
- Dobutamine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 400mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- D4335
- Product name
- Dobutamine Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 20mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- D4335
- Product name
- Dobutamine Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $110
- Updated
- 2024/03/01
Dobutamine hydrochloride Chemical Properties,Usage,Production
Description
Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.
Chemical Properties
Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.
Uses
Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.
Uses
Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.
Definition
ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure.
brand name
Dobutrex (Lilly）.
Biological Activity
β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.
Biochem/physiol Actions
Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.
Pharmacokinetics
Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.
Veterinary Drugs and Treatments
Dobutamine is used as a rapid-acting injectable positive inotropic agent for short-term treatment of heart failure. It is also useful in shock patients when fluid therapy alone has not restored acceptable arterial blood pressure, cardiac output, or tissue perfusion.
storage
Desiccate at RT
Dobutamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Dobutamine hydrochloride Suppliers
- Tel
- --
- Fax
- --
- discovery@discoverychem.com.br
- Country
- Brazil
- ProdList
- 390
- Advantage
- 58
View Lastest Price from Dobutamine hydrochloride manufacturers
- Product
- Dobutamine hydrochloride 49745-95-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 20 tons
- Release date
- 2024-03-13
- Product
- Dobutamine hydrochloride 49745-95-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98% HPLC
- Supply Ability
- 500 kgs
- Release date
- 2024-05-15
- Product
- DOBUTAMINE HYDROCHLORIDE 49745-95-1
- Price
- US $5238.10/KG
- Min. Order
- 20g
- Purity
- 99%
- Supply Ability
- 3000g
- Release date
- 2021-06-08