Dobutamine hydrochloride

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Dobutamine hydrochloride

Product Name: Dobutamine hydrochloride
CAS No.: 49745-95-1
Chemical Name: Dobutamine hydrochloride
Synonyms: DOBUTAMINE HCL;Dobutrex;46236;Dobux;Dopmin;Inotrex;NSC 299583;Dobutamine hydrochlo;Dobutamine hydrochloride;DL-Dobutamine hydrochloride
CBNumber: CB8274063
Molecular Formula: C18H24ClNO3
Formula Weight: 337.84
MOL File: 49745-95-1.mol

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Dobutamine hydrochloride Property

Melting point:: 184-186 C
storage temp.: 2-8°C
solubility: Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent).
pka: 9.45(at 25℃)
form: Solid
color: White to Off-White
Water Solubility: Soluble in water or ethanol with warming. Also soluble in methanol
λmax: 281nm(MeOH)(lit.)
Merck: 14,3395
Stability:: Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light.
InChI: InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
InChIKey: BQKADKWNRWCIJL-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl
CAS DataBase Reference: 49745-95-1(CAS DataBase Reference)
EPA Substance Registry System: 1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-63-36/37/38-R63-R62-R11-R21-R20
Safety Statements: 22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22
WGK Germany: 3
HS Code: 29222990
Toxicity: LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D0676
Product name: Dobutamine hydrochloride
Purity: ≥98%
Packaging: 10mg
Price: $84.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP674
Product name: Dobutamine hydrochloride
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $223
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1224507
Product name: Dobutamine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 400mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: D4335
Product name: Dobutamine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $36
Updated: 2024/03/01

TCI Chemical

Product number: D4335
Product name: Dobutamine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $110
Updated: 2024/03/01

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Dobutamine hydrochloride Chemical Properties,Usage,Production

Description

Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.

Chemical Properties

Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.

Uses

Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.

Uses

Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.

Definition

ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure.

brand name

Dobutrex (Lilly）.

Biological Activity

β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Pharmacokinetics

Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.

Veterinary Drugs and Treatments

Dobutamine is used as a rapid-acting injectable positive inotropic agent for short-term treatment of heart failure. It is also useful in shock patients when fluid therapy alone has not restored acceptable arterial blood pressure, cardiac output, or tissue perfusion.

storage

Desiccate at RT

Dobutamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dobutamine hydrochloride manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: Dobutamine hydrochloride 49745-95-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98% HPLC
Supply Ability: 500 kgs
Release date: 2024-05-15

airuikechemical co., ltd.

Product: Dobutamine hydrochloride 49745-95-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 20 tons
Release date: 2024-03-13

Baoji Guokang Healthchem co.,ltd

Product: DOBUTAMINE HYDROCHLORIDE 49745-95-1
Price: US $5238.10/KG
Min. Order: 20g
Purity: 99%
Supply Ability: 3000g
Release date: 2021-06-08

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DOBUTAMINE HCL

4-[2-[3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]AMINOETHYL]-1,2-BENZENEDIOL HYDROCHLORIDE

4-[2-[4-(4-HYDROXYPHENYL)BUTAN-2-YLAMINO]ETHYL]BENZENE-1,2-DIOL

[+/-]-3,4-DIHYDROXY-N-[3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-BETA-PHENETHYLAMINE HYDROCHLORIDE

4-[2-[[3-(p-hydroxyphenyl)-1-methylpropyl]amino]ethyl]pyrocatechol hydrochloride

Inotrex

(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride

1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride

DL-Dobutamine hydrochloride

Dobutrex

NSC 299583

Dobutamine hydrochloride

rac Dobutamine Hydrochloride

Dobutamine hydrochloride,(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride

Dobutamine Hydrochloride (600 mg)

(+)-p-[2-[3-(p-Hydroxyphenyl)-1-methylpropylamino]ethyl]pyrocatechol hydrochloride

46236

Dobux

Dopmin

4-(2-(4-(4-hydroxyphenyl)butan-2-ylaMino)ethyl)benzene-1,2-diol hydrochloride

1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-Methylpropyl]aMino]ethyl]-, hydrochloride (1:1)

Dobutamine Hydrochloride (400 mg)

Dobutamine Hydrochloride RS

Dobutamine hydrochloride CRS

Dobutamine Hydrochloride &gt

DOBUTAMINE HYDROCHLORIDE USP/EP/BP

Dobutamine hydrochlo

Dobutamine hydrochlorideQ: What is Dobutamine hydrochloride Q: What is the CAS Number of Dobutamine hydrochloride Q: What is the storage condition of Dobutamine hydrochloride Q: What are the applications of Dobutamine hydrochloride

CAS49745-95-1 DOBUTAMINE HYDROCHLORIDE

Dobutamine Hydrochloride (1224507)

Dobutamine hydrochloride, beta1 and beta2 adrenoceptor agonist

49745-95-1

C18H23NO3xHCl

C18H23NO3HCl

Adrenoceptor

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