3-chloro-2-methyl-5-nitro-pyridine
- Product Name
- 3-chloro-2-methyl-5-nitro-pyridine
- CAS No.
- 51984-62-4
- Chemical Name
- 3-chloro-2-methyl-5-nitro-pyridine
- Synonyms
- 3-chloro-2-methyl-5-nitro-pyridine;Pyridine, 3-chloro-2-methyl-5-nitro-
- CBNumber
- CB82742555
- Molecular Formula
- C6H5ClN2O2
- Formula Weight
- 172.57
- MOL File
- 51984-62-4.mol
3-chloro-2-methyl-5-nitro-pyridine Property
- Boiling point:
- 248.7±35.0 °C(Predicted)
- Density
- 1.406±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.37±0.20(Predicted)
- Appearance
- Brown to reddish brown Solid
- InChI
- InChI=1S/C6H5ClN2O2/c1-4-6(7)2-5(3-8-4)9(10)11/h2-3H,1H3
- InChIKey
- KEQYIUZGVFBSNL-UHFFFAOYSA-N
- SMILES
- C1(C)=NC=C([N+]([O-])=O)C=C1Cl
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C382215
- Product name
- 3-Chloro-2-Methyl-5-Nitropyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2759CY
- Product name
- 3-Chloro-2-methyl-5-nitropyridine
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 2759CY
- Product name
- 3-Chloro-2-methyl-5-nitropyridine
- Packaging
- 10g
- Price
- $478
- Updated
- 2021/12/16
- Product number
- 153948
- Product name
- 3-Chloro-2-methyl-5-nitropyridine
- Purity
- 95%
- Packaging
- 10g
- Price
- $2036
- Updated
- 2021/12/16
- Product number
- A261818
- Product name
- 3-Chloro-2-methyl-5-nitropyridine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
3-chloro-2-methyl-5-nitro-pyridine Chemical Properties,Usage,Production
Synthesis
22353-40-8
13061-96-6
51984-62-4
General procedure for the synthesis of 3-chloro-2-methyl-5-nitropyridine from 2,3-dichloro-5-nitropyridine and methylboronic acid: Cesium carbonate (338 mg, 1.04 mmol), methylboronic acid (47 mg, 0.78 mmol) and tetrakis(triphenylphosphine)palladium (60 mg, 0.052 mmol) were sequentially added to a solution of 1,4-dioxane (3 mL) containing 2,3-dichloro-5-nitropyridine (191 mg, 1.00 mmol), protected by argon gas. -5-nitropyridine (191 mg, 1.00 mmol) to a solution of 1,4-dioxane (3 mL). The reaction mixture was stirred at 100 °C for 6 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, water (10 mL) was added and extracted with ethyl acetate (3 × 10 mL). The organic phases were combined, washed with saturated saline (10 mL) and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give the crude product. Purification by column chromatography (eluent: petroleum ether/ethyl acetate = 5:1) afforded 3-chloro-2-methyl-5-nitropyridine (344 mg, 90% yield) as a pale yellow solid.
References
[1] Patent: EP2589592, 2018, B1. Location in patent: Paragraph 1190; 1191
3-chloro-2-methyl-5-nitro-pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-chloro-2-methyl-5-nitro-pyridine Suppliers
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