mPEG8-Alkyne
- Product Name
- mPEG8-Alkyne
- CAS No.
- 880081-81-2
- Chemical Name
- mPEG8-Alkyne
- Synonyms
- mPEG8-Alkyne;MPEG8-PROPYNE;mPEG11-Alkyne;m-PEG8-O-alkyne;m-PEG9-Propargyl;2,5,8,11,14,17,20,23,26-Nonaoxanonacos-28-yne;mPEG8-Propyne/2,5,8,11,14,17,20,23,26-Nonaoxanonacos-28-yne;inhibit,m-PEG-8-O-alkyne,PROTAC Linkers,m PEG8 O alkyne,Inhibitor,mPEG8Oalkyne
- CBNumber
- CB82747176
- Molecular Formula
- C20H38O9
- Formula Weight
- 422.51
- MOL File
- 880081-81-2.mol
mPEG8-Alkyne Property
- Boiling point:
- 468.8±40.0 °C(Predicted)
- Density
- 1.057±0.06 g/cm3(Predicted)
- storage temp.
- Store at 0-8 °C
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 283903
- Product name
- mPEG8-Propyne
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- AS104121
- Product name
- mPEG8-Propyne
- Purity
- 95+%
- Packaging
- 1g
- Price
- $471
- Updated
- 2021/12/16
- Product number
- 283903
- Product name
- mPEG8-Propyne
- Packaging
- 5g
- Price
- $1499
- Updated
- 2021/12/16
- Product number
- 3664908
- Product name
- mPEG8-CH2C≡CH
- Purity
- min.97%
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 3664908
- Product name
- mPEG8-CH2C≡CH
- Purity
- min.97%
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
mPEG8-Alkyne Chemical Properties,Usage,Production
Uses
m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG8-O-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
mPEG8-Alkyne Preparation Products And Raw materials
Raw materials
Preparation Products
mPEG8-Alkyne Suppliers
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View Lastest Price from mPEG8-Alkyne manufacturers
- Product
- mPEG8-Propargyl 880081-81-2
- Price
- US $951.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-18
- Product
- Propargyl-PEG9-methane 880081-81-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-26