ChemicalBook > CAS DataBase List > 3,3',5-TRIIODOTHYROACETIC ACID
3,3',5-TRIIODOTHYROACETIC ACID
- Product Name
- 3,3',5-TRIIODOTHYROACETIC ACID
- CAS No.
- 51-24-1
- Chemical Name
- 3,3',5-TRIIODOTHYROACETIC ACID
- Synonyms
- TIRATRICOL;TRIAC;Levothyroxine EP Impurity C;T3A;Nidolin;Triacana;Tilaquke;TRIIODOTHYROACETICACID;Levothyroxine Impurity C;Liothyronine EP Impurity C
- CBNumber
- CB8275848
- Molecular Formula
- C14H9I3O4
- Formula Weight
- 621.93
- MOL File
- 51-24-1.mol
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3,3',5-TRIIODOTHYROACETIC ACID Property
- Melting point:
- 65°; mp 180-183°
- Boiling point:
- 531.6±50.0 °C(Predicted)
- Density
- 2.466±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
- form
- Solid
- pka
- 4.02±0.10(Predicted)
- color
- White to Pale Beige
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- T7650
- Product name
- 3,3′,5-Triiodothyroacetic acid
- Purity
- ≥90%
- Packaging
- 100mg
- Price
- $135
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- T7650
- Product name
- 3,3′,5-Triiodothyroacetic acid
- Purity
- ≥90%
- Packaging
- 1g
- Price
- $620
- Updated
- 2024/03/01
TCI Chemical
- Product number
- T3878
- Product name
- 3,3',5-Triiodothyroacetic Acid
- Packaging
- 200MG
- Price
- $176
- Updated
- 2024/03/01
TCI Chemical
- Product number
- T3878
- Product name
- 3,3',5-Triiodothyroacetic Acid
- Packaging
- 1G
- Price
- $337
- Updated
- 2021/12/16
Cayman Chemical
- Product number
- 28729
- Product name
- Tiratricol
- Packaging
- 100mg
- Price
- $61
- Updated
- 2024/03/01
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3,3',5-TRIIODOTHYROACETIC ACID Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Originator
Triacana,Ana,Italy,1972
Uses
thyroid agent
Uses
3,3'',5-Triiodo Thyroacetic Acid (T3-Acetic Acid (USP)) is a thyroid hormone analogue. A potent Thyroxine impurity. Levothyroxine EP Impurity C.
Manufacturing Process
Preparation of 3:5-diiodo-4-(4'-hydroxyphenoxy)phenylacetic acid (diacid): A
solution of ethyl 3:5-diiodo-4-(4'-methoxyphenoxy)phenyl acetate (9.5 g) in
acetic acid (60 ml) was heated under reflux with hydroiodic acid (SG 1.7, 50
ml) and red phosphorus (0.5 g) for 1 hour. The hot solution was filtered and
the filtrate concentrated at 50°C and 15 mm of mercury to above 20 ml. The
residue was treated with water (70 ml) containing a little sodium thiosulfate
to decolorize the product. The solid was collected by filtration and purified by
the method of Harington and Pitt-Rivers [Biochem. J. (1952), Vol. 50, page
438]. Yield 8.36 g (95%). After crystallization from 70% (v/v) acetic acid it
melted at 219°C.
A solution of 438 mg of diac in methanol (20 ml) and ammonia solution (SG
0.88; 20 ml) was iodinated at 0°C with 1.8 ml 1 N iodine solution. The
product was isolated in almost theoretical yield in a manner similar to that
described for tetrac. After crystallization from 50% (v/v) methanol, triac was
obtained as colorless needles which melted over the range 65°C to 90°C
according to the rate of heating. The molten form resolidified at about 110°C
and finally melted at 180°C to 181°C without decomposition. The compound,
dried at 25°C/3 mm over silica gel, contains methanol of crystallization.
Therapeutic Function
Thyroid hormone
3,3',5-TRIIODOTHYROACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,3',5-TRIIODOTHYROACETIC ACID manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Tiratricol 51-24-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%101% HPLC
- Supply Ability
- 1000G
- Release date
- 2021-08-13
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
- Product
- Tiratricol 51-24-1
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-10-14
Career Henan Chemical Co
- Product
- 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid 51-24-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-14
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