2-Amino-3-methyl-5-nitropyridine
Uses- Product Name
- 2-Amino-3-methyl-5-nitropyridine
- CAS No.
- 18344-51-9
- Chemical Name
- 2-Amino-3-methyl-5-nitropyridine
- Synonyms
- 3-METHYL-5-NITROPYRIDIN-2-AMINE;2-Bromo-5-Nitro-3;TIMTEC-BB SBB005535;2-AMINO-5-NITRO-3-PICOLINE;2-Amino-5-nitro-3-picoline,98%;3-Methyl-5-nitro-2-pyridinamine;2-AMINO-3-METHYL-5-NITROPYRIDINE;2-Amino-5-nitro-3-methylpyridine;3-Methyl-5-nitropyridine-2-amine;2-Pyridinamine,3-methyl-5-nitro-
- CBNumber
- CB8294382
- Molecular Formula
- C6H7N3O2
- Formula Weight
- 153.14
- MOL File
- 18344-51-9.mol
2-Amino-3-methyl-5-nitropyridine Property
- Melting point:
- 256-260 °C
- Boiling point:
- 276.04°C (rough estimate)
- Density
- 1.3682 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 3.13±0.49(Predicted)
- form
- powder to crystal
- color
- Light yellow to Yellow to Orange
- BRN
- 126947
- InChI
- InChI=1S/C6H7N3O2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3H,1H3,(H2,7,8)
- InChIKey
- JLPYUDJJBGYXEZ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C([N+]([O-])=O)C=C1C
- CAS DataBase Reference
- 18344-51-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-20/21/22-41-22
- Safety Statements
- 36/37/39-26-22-39-36-37
- RIDADR
- UN2811
- WGK Germany
- 1
- HazardClass
- IRRITANT
- HS Code
- 29333990
N-Bromosuccinimide Price
- Product number
- 703974
- Product name
- 2-Amino-3-methyl-5-nitropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $56
- Updated
- 2023/06/20
- Product number
- 703974
- Product name
- 2-Amino-3-methyl-5-nitropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $57.7
- Updated
- 2023/01/07
- Product number
- A1891
- Product name
- 2-Amino-3-methyl-5-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- A1891
- Product name
- 2-Amino-3-methyl-5-nitropyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- A1378-92
- Product name
- 2-Amino-3-methyl-5-nitropyridine
- Packaging
- 1g
- Price
- $425
- Updated
- 2021/12/16
2-Amino-3-methyl-5-nitropyridine Chemical Properties,Usage,Production
Uses
2-Amino-3-methyl-5-nitropyridine is a pyridine derivative that can be used as a pharmaceutical intermediate.
Chemical Properties
White to yellow crystalline powder.
Synthesis
1603-40-3
18344-51-9
The general procedure for the synthesis of 2-amino-3-methyl-5-nitropyridine from 2-amino-3-methylpyridine was as follows: 3-methylpyridin-2-amine (5.0 g, 46.2 mmol) was dissolved in concentrated sulfuric acid (24 mL) and the mixture was cooled to 0 °C. At the same time, fuming nitric acid (density = 1.5, 3.5 mL) was cooled to 0 °C. Concentrated sulfuric acid (3.5 mL) was slowly added dropwise to the reaction mixture while keeping the temperature below 20°C. Subsequently, the stirred mixture was gradually warmed to 20 °C and transferred to a second flask in 3-5 mL batches. The second flask was heated to 35-40°C (note: the temperature should not exceed 40°C and the temperature should be carefully monitored after each addition of a new batch). Next, the reaction mixture was continued to be stirred at 50°C for 30 minutes. Once the reaction is complete, the mixture is cooled to room temperature and neutralized with concentrated ammonia. At this point, a precipitate is generated, which is filtered and washed sequentially with water and 50% aqueous DMFA (6 mL). Finally, the product was purified by recrystallization from DMFA to give 3-methyl-5-nitropyridin-2-amine (2.52 g, 35% yield).
References
[1] Patent: EP1894924, 2008, A1. Location in patent: Page/Page column 36
[2] Journal of Organic Chemistry, 1949, vol. 14, p. 328,331
[3] Journal of the American Chemical Society, 1955, vol. 77, p. 3154
2-Amino-3-methyl-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-3-methyl-5-nitropyridine Suppliers
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View Lastest Price from 2-Amino-3-methyl-5-nitropyridine manufacturers
- Product
- 2-Amino-3-methyl-5-nitropyridine 18344-51-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 2-Amino-3-methyl-5-nitropyridine 18344-51-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- 2-Amino-3-methyl-5-nitropyridine 18344-51-9
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08