ChemicalBook > CAS DataBase List > 3-(Trifluoromethyl)cinnamic acid
3-(Trifluoromethyl)cinnamic acid
- Product Name
- 3-(Trifluoromethyl)cinnamic acid
- CAS No.
- 779-89-5
- Chemical Name
- 3-(Trifluoromethyl)cinnamic acid
- Synonyms
- 3-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-ENOIC ACID;MTF-CNA;Cinacalcet-27;TIMTEC-BB SBB000553;RARECHEM BK HW 0018;CINMIC ACID IMPURITY;Cinacalcet Impurity 40;3-[3-(Trifluoromethyl)Pheny;m-(Trifluoromethyl)Cinnamic;3-rifluoromethyl)CinnamicAcid
- CBNumber
- CB8295905
- Molecular Formula
- C10H7F3O2
- Formula Weight
- 216.16
- MOL File
- 779-89-5.mol
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3-(Trifluoromethyl)cinnamic acid Property
- Melting point:
- 135-137 °C(lit.)
- Boiling point:
- 224°C (rough estimate)
- Density
- 1.3275 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.25±0.10(Predicted)
- color
- White to Off-White
- BRN
- 1963372
- InChI
- InChI=1S/C10H7F3O2/c11-10(12,13)8-3-1-2-7(6-8)4-5-9(14)15/h1-6H,(H,14,15)
- InChIKey
- KSBWHDDGWSYETA-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C=CC1=CC=CC(C(F)(F)F)=C1
- CAS DataBase Reference
- 779-89-5(CAS DataBase Reference)
- EPA Substance Registry System
- 3-[3-(Trifluoromethyl)phenyl]acrylic acid (779-89-5)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-37/38
- Safety Statements
- 26-37/39-37
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29163990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- T1547
- Product name
- 3-(Trifluoromethyl)cinnamic Acid
- Purity
- >99.0%(GC)(T)
- Packaging
- 5g
- Price
- $113
- Updated
- 2025/07/31
TCI Chemical
- Product number
- T1547
- Product name
- 3-(Trifluoromethyl)cinnamic Acid
- Purity
- >99.0%(GC)(T)
- Packaging
- 25g
- Price
- $340
- Updated
- 2025/07/31
TRC
- Product number
- T791225
- Product name
- 3-(Trifluoromethyl)cinnamic Acid
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- JK954997
- Product name
- 3-(Trifluoromethyl)cinnamic Acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $48
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC7663
- Product name
- 3-(Trifluoromethyl)cinnamic Acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $63
- Updated
- 2021/12/16
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3-(Trifluoromethyl)cinnamic acid Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Had sedative hypnotic activity in mice, showing potent inhibition of spontaneous motility.
Uses
3-(Trifluoromethyl)cinnamic acid is used in the synthesis of cinacalcet. Cinacalcet is a drug for the control and treatment of secondary hyperparathyroidism (in the dialysis population), primary hyperparathyroidism where the patient may not be a candidate for surgical treatment, and for the treatment of calciphylaxis in patients with end-stage renal disease or in patients on dialysis.
Definition
ChEBI: (E)-3-(trifluoromethyl)cinnamic acid is a member of the class of (trifluoromethyl)benzenes consisting of trans-cinnamic acid having a trifluoromethyl substituent at the meta-position. It is a member of cinnamic acids, a member of styrenes and a member of (trifluoromethyl)benzenes. It is functionally related to a trans-cinnamic acid.
Synthesis
To a suspension of m-trifluoromethyl-α-bromohydrocinnamic acid, isopropanol (1.42 1) and benzyltriethylammonium chloride (10.85g), aqueous sodium hydroxide (340 ml, 56%) was added slowly. The temperature was raised to 55-60℃, stirred for 7 hours, and isopropanol was removed in vacuo. Water (500ml) was added to the reaction mass, stirred, cooled to 0℃, and acidified with hydrochloric acid (450ml). The solid was filtered, washed with water, and dried in vacuo at 5O℃ to afford 204g of 3-(Trifluoromethyl)cinnamic acid.
3-(Trifluoromethyl)cinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(Trifluoromethyl)cinnamic acid manufacturers
Shandong Jihui Chemical Co., Ltd.
- Product
- 3-(Trifluoromethyl)cinnamic acid 779-89-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- Purity: 99%
- Supply Ability
- 50tons
- Release date
- 2025-07-21
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- Product
- 3-(Trifluoromethyl)cinnamic acid 779-89-5
- Price
- US $999.00-666.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-09
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 3-(Trifluoromethyl)cinnamic acid 779-89-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
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