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Triphenylphosphine oxide

Product Name
Triphenylphosphine oxide
CAS No.
791-28-6
Chemical Name
Triphenylphosphine oxide
Synonyms
TPO;TPPO;Ph3PO;TTPO;Triphenylphosphinoxid;triphenylphosphane oxide;Trisphenylphosphine oxide;Triphenyl phosphorus oxide;Orlistat Related CoMpound C;PP 560
CBNumber
CB8296821
Molecular Formula
C18H15OP
Formula Weight
278.28
MOL File
791-28-6.mol
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Triphenylphosphine oxide Property

Melting point:
150-157 °C(lit.)
Boiling point:
360 °C
Density 
1,212 g/cm3
bulk density
400-450kg/m3
vapor pressure 
<1 hPa (50 °C)
Flash point:
180 °C
storage temp. 
Store below +30°C.
solubility 
methanol: 25 mg/mL, clear
form 
Crystalline Powder or Flakes
color 
White to pink-brown
Specific Gravity
1.212
Water Solubility 
slightly soluble
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN 
745854
LogP
2.8
CAS DataBase Reference
791-28-6(CAS DataBase Reference)
NIST Chemistry Reference
(C6H5)3PO(791-28-6)
EPA Substance Registry System
Triphenylphosphine oxide (791-28-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-52/53
Safety Statements 
26-61-36
RIDADR 
3077
WGK Germany 
2
RTECS 
SZ1676000
Autoignition Temperature
590 °C
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29310095
Toxicity
LD50 orally in Rabbit: 685 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H290May be corrosive to metals

Precautionary statements

P234Keep only in original container.

P390Absorb spillage to prevent material damage.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2544
Product name
Orlistat Related Compound C
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$602
Updated
2024/03/01
Sigma-Aldrich
Product number
1478833
Product name
Orlistat Related Compound C
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1490
Updated
2024/03/01
Sigma-Aldrich
Product number
08902
Product name
Triphenylphosphine oxide
Purity
analytical standard
Packaging
100mg
Price
$151
Updated
2024/03/01
TCI Chemical
Product number
T0625
Product name
Triphenylphosphine Oxide
Purity
>98.0%(GC)
Packaging
25g
Price
$27
Updated
2024/03/01
TCI Chemical
Product number
T0625
Product name
Triphenylphosphine Oxide
Purity
>98.0%(GC)
Packaging
100g
Price
$58
Updated
2024/03/01
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Triphenylphosphine oxide Chemical Properties,Usage,Production

Description

Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.

Chemical Properties

White solid

Uses

Triphenylphosphine Oxide (Orlistat USP Related Compound C) is a catalyst in the conversion of aldehydes into 1,1-dichlorides. Triphenylphosphine Oxide is used as a catalyst for the synthesis of hightly functionalized α-CF3 γ-keto esters.

Uses

Triphenylphosphine oxide can be used:
As a catalyst in Appel-type chlorination reaction of acyclic primary and secondary alcohols.
As a catalyst in stereoselective poly and dibromination of α,β-unsaturated esters and β,γ-unsaturated α-ketoester compounds.
As a promotor in the diastereoselective synthesis of α-ribofuranosides through ribofuranosylation of alcohols with ribofuranosyl iodides.

Uses

Triphenylphosphine oxide is a phosphine ligand used for coupling reactions, epoxidations, and Michael reactions

Definition

ChEBI: A phosphine oxide in which the substituents on phosphorus are three phenyl groups.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 5463, 1990 DOI: 10.1016/S0040-4039(00)97873-0

Flammability and Explosibility

Not classified

reaction suitability

reagent type: ligand
reaction type: Coupling Reactions
reagent type: ligand
reaction type: Epoxidations
reagent type: ligand
reaction type: Michael Reaction

Purification Methods

It crystallises from absolute EtOH and is dried in vacuo. The gold chloride complex has m 177.5-178.5o. [Addison & Sheldon J Chem Soc 2705 1956, Cox & Westheimer J Am Chem Soc 80 5441 1958, Beilstein 16 III 864, 16 1011.]

Triphenylphosphine oxide Preparation Products And Raw materials

Raw materials

Preparation Products

1-METHYLTHYMINE
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View Lastest Price from Triphenylphosphine oxide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Triphenylphosphine oxide 791-28-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-05-10
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Triphenylphosphine oxide 791-28-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-23
Hebei Weibang Biotechnology Co., Ltd
Product
Triphenylphosphine oxide 791-28-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21

791-28-6, Triphenylphosphine oxideRelated Search:

Tri(o-tolyl)phosphine Diphenylphosphine oxide Iron oxide black Zinc oxide Triphenylantimony Rutile NITRIC OXIDE Chlorodiphenylphosphine Boron oxide Iron oxide ETHYLENE OXIDE Triphenylphosphine Tris(triphenylphosphine)ruthenium(II) chloride Triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt Triphenylmethyl Chloride Triphenyl(propyl)phosphonium Orlistat USP RC E (Diethoxymethyl)diphenylphosphine oxide

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