Camostat mesilate

ChemicalBook > CAS DataBase List > Camostat mesilate

Product Name: Camostat mesilate
CAS No.: 59721-29-8
Chemical Name: Camostat mesilate
Synonyms: Foipan;CAMOSTAT MESYLATE;CS-129;FOY-S 980;Foipan mesylate;Camostat (FOY305;CAMOSTAT MESILATE;Camostatemesylate;Camostate mesilate;Camosetam mesylate
CBNumber: CB8299877
Molecular Formula: C21H26N4O8S
Formula Weight: 494.52
MOL File: 59721-29-8.mol

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Camostat mesilate Property

Melting point:: 150-1550C
RTECS: CY1571620
storage temp.: 2-8°C
solubility: H2O: ≥24mg/mL
form: powder
color: white to tan
Water Solubility: Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).
Merck: 14,1728
Stability:: Stable for 2 years? from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
CAS DataBase Reference: 59721-29-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N
Risk Statements: 36/37/38-50
Safety Statements: 26-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HazardClass: 9
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0057
Product name: Camostat mesylate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $68.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0057
Product name: Camostat mesylate
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $260
Updated: 2024/03/01

TCI Chemical

Product number: C2977
Product name: Camostat Mesylate
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $88
Updated: 2024/03/01

TCI Chemical

Product number: C2977
Product name: Camostat Mesylate
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $262
Updated: 2024/03/01

Alfa Aesar

Product number: J62362
Product name: Camostat methanesulfate, 98%
Packaging: 100mg
Price: $365.65
Updated: 2024/03/01

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Camostat mesilate Chemical Properties,Usage,Production

Description

Camostat mesylate is a broad spectrum protease inhibitor useful in the treatment of chronic pancreatitis.

Chemical Properties

Crystalline Solid

Originator

Ono (Japan)

Uses

It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.

Uses

Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor

Definition

ChEBI: Camostat mesylate is a methanesulfonate (mesylate) salt prepared from equimolar amounts of camostat and methanesulfonic acid. It is a serine protease inhibitor approved and marketed in Japan in 1985 for the alleviation of acute symptoms associated with chronic pancreatitis. In 1994, it was approved for the treatment of postoperative reflux esophagitis. It has a role as an anticoronaviral agent, an anti-inflammatory agent, an antifibrinolytic drug, an antihypertensive agent, an antineoplastic agent, an antiviral agent and a serine protease inhibitor. It contains a camostat(1+).

brand name

FOIPAN

Biological Activity

Orally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration.

storage

Desiccate at RT

References

1) Gibo?et al.?(2005),?Camostat mesylate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity;?Lab Invest.,?85?75 2) Albarazanji?et al.?(2019),?Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.; Am. J. Physiol. Gastrointest. Liver Physiol.,?316?G653 3) Ueda?et al.?(2015),?The serine protease inhibitor camostat mesylate attenuates the progression of chronic kidney disease through its antioxidant effects; Nephron,?129?223 4) Yamaya?et al.?(2015),?The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells; Pulm. Pharmacol. Ther.,?33?66 5) Hoffmann?et al.?(2020),?SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor; Cell, 181 271

Camostat mesilate Preparation Products And Raw materials

Raw materials

Preparation Products

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Camostat mesilate Suppliers

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View Lastest Price from Camostat mesilate manufacturers

airuikechemical co., ltd.

Product: CAMOSTAT MESILATE 59721-29-8
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Camostat mesilate 59721-29-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.5%
Supply Ability: 10kg/month
Release date: 2021-06-17

Henan Fengda Chemical Co., Ltd

Product: Camostat mesilate 59721-29-8
Price: US $8.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

59721-29-8, Camostat mesilateRelated Search:

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p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcarbamoylmethyleste

Camostatemesylate

CAMOSTAT MESILATE

CAMOSTAT MESYLATE

2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate

4-[[4-[(AMINOIMINOMETHYL)AMINO]BENZOYL]OXY]BENZENEACETIC ACID 2-(DIMETHYLAMINO)-2-OXOETHYL ESTER METHANESULFONATE; FOY305

CS-129

Camostat (FOY305

CAMOSTAT (FOY305; FOY-S980)

4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate

Foipan

FOY-S 980

4-Guanidinobenzoic acid 4-[[[(dimethylcarbamoyl)methoxy]carbonyl]methyl]phenyl·methanesulfonic acid

Camostate mesilate

4-(2-(2-(diMethylaMino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate Methanesulfonate

Benzeneacetic acid, 4-[[4-[(aMinoiMinoMethyl)aMino]benzoyl]oxy]-, 2-(diMethylaMino)-2-oxoethyl ester, Methanesulfonate

Camostat mesylate(FOY-305)

Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, methanesulfonate (1:1)

Foipan mesylate

Camostat mesylate (Camostat mesilate)

CaMostat Mesilate, CaMostat Mesylate

4-{2-[(diMethylcarbaMoyl)Methoxy]-1-(Methanesulfonyloxy)-2-oxoethyl}phenyl 4-carbaMiMidaMidobenzoate

Camostat Mesylate &gt

Camostat Mesilate RS

Camostat Methanesulfonate

Camostat mesilate USP/EP/BP

Camostat Mesilate,≥98%

Camostat Mesilate (FOY305)

Camostat MesylateQ: What is Camostat Mesylate Q: What is the CAS Number of Camostat Mesylate Q: What is the storage condition of Camostat Mesylate Q: What are the applications of Camostat Mesylate

Camorestat mesylate

Camosetam mesylate

Camostat Mesylate CRS

FOY-S980|||FOY305|||Camostat mesilate

59721-29-8

C20H22N4O5CH3SO3H

C20H22N4O5CH4O3S

C21H26N4O8S

C20H26N4O8S

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