2-IODO-5-NITROBENZOIC ACID
- Product Name
- 2-IODO-5-NITROBENZOIC ACID
- CAS No.
- 19230-50-3
- Chemical Name
- 2-IODO-5-NITROBENZOIC ACID
- Synonyms
- 2-IODO-5-NITROBENZOIC ACID;Benzoic acid,2-iodo-5-nitro-
- CBNumber
- CB8300881
- Molecular Formula
- C7H4INO4
- Formula Weight
- 293.02
- MOL File
- 19230-50-3.mol
2-IODO-5-NITROBENZOIC ACID Property
- Melting point:
- 197-198 °C
- Boiling point:
- 394.2±37.0 °C(Predicted)
- Density
- 2.156±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 2.16±0.10(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C7H4INO4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3H,(H,10,11)
- InChIKey
- JSSFIFUXHORXJX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC([N+]([O-])=O)=CC=C1I
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I706415
- Product name
- 2-Iodo-5-nitrobenzoicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- X8087
- Product name
- 2-Iodo-5-nitrobenzoicacid
- Packaging
- 5g
- Price
- $296
- Updated
- 2021/12/16
- Product number
- HCH0055120
- Product name
- 2-IODO-5-NITROBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $353.85
- Updated
- 2021/12/16
- Product number
- X8087
- Product name
- 2-Iodo-5-nitrobenzoicacid
- Packaging
- 1g
- Price
- $154
- Updated
- 2021/12/16
- Product number
- X8087
- Product name
- 2-Iodo-5-nitrobenzoicacid
- Packaging
- 10g
- Price
- $451
- Updated
- 2021/12/16
2-IODO-5-NITROBENZOIC ACID Chemical Properties,Usage,Production
Uses
2-iodo-5-nitrobenzoic acid is a useful reactant for the synthesis of 2-?Arylquinazolines and Tetracyclic Isoindolo[1,?2-?a]?quinazoline.
Synthesis
88-67-5
19230-50-3
During this preparation, up to 25 mmol of I2 is generated. therefore, the synthesis operation must be carried out in a well-ventilated fume hood. The preparation was carried out with reference to the literature method [10]. 2-Iodobenzoic acid (4.10 g, 40.3 mmol, 1 equiv) was added to a mixed solution of HNO3 (35 mL, 65%) and H2SO4 (85 mL, 95%). The reaction mixture was heated to 135 °C and stirred at this temperature for 1 hour. Upon completion of the reaction, the resulting brown slurry was poured on ice, filtered to collect the gray precipitate, and washed with plenty of water. Subsequently, the filter cake was suspended in water (100 mL), heated to 100 °C and a solution consisting of KI (8.5 g, 51.2 mmol, 1.3 eq.) and H2SO4 (5 drops) dissolved in water (10 mL) was added in the process and the reaction was continued for 1 hour. Finally, the brown suspension was filtered while hot and washed with cold water to give the pure product 2-iodo-5-nitrobenzoic acid (5 g, 42% yield) as a brown solid. If the product is impure, it can be purified by boiling in water and then hot filtering.
References
[1] Journal of Organic Chemistry, 2005, vol. 70, # 12, p. 4778 - 4783
[2] Synlett, 2013, vol. 24, # 13, p. 1707 - 1711
[3] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 1 - 6
[4] Organic Letters, 2011, vol. 13, # 3, p. 518 - 521
[5] Helvetica Chimica Acta, 1930, vol. 13, p. 310,311
2-IODO-5-NITROBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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