4-Iodo-3-nitrobenzoic acid
- Product Name
- 4-Iodo-3-nitrobenzoic acid
- CAS No.
- 35674-27-2
- Chemical Name
- 4-Iodo-3-nitrobenzoic acid
- Synonyms
- 4-iodo-3-nitrobenzoicaci;3-Nitro-4-iodobenzoic acid;4-IODO-3-NITROBENZOIC ACID;Benzoic acid, 4-iodo-3-nitro-;4-Iodo-3-nitrobenzoic acid ,98%
- CBNumber
- CB5372047
- Molecular Formula
- C7H4INO4
- Formula Weight
- 293.02
- MOL File
- 35674-27-2.mol
4-Iodo-3-nitrobenzoic acid Property
- Melting point:
- 208-211°C
- Boiling point:
- 390.2±37.0 °C(Predicted)
- Density
- 2.156±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- powder to crystal
- pka
- 3.32±0.10(Predicted)
- color
- Light orange to Yellow to Green
- Water Solubility
- Insoluble in water.
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C7H4INO4/c8-5-2-1-4(7(10)11)3-6(5)9(12)13/h1-3H,(H,10,11)
- InChIKey
- DNMTZLCNLAIKQC-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(I)C([N+]([O-])=O)=C1
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-26-36/37/39
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- I0980
- Product name
- 4-Iodo-3-nitrobenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- I0980
- Product name
- 4-Iodo-3-nitrobenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $100
- Updated
- 2025/07/31
- Product number
- I706343
- Product name
- 4-Iodo-3-nitrobenzoic Acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W002638
- Product name
- 4-Iodo-3-nitrobenzoic Acid
- Purity
- 99.49%
- Packaging
- 5g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- CS-W002638
- Product name
- 4-Iodo-3-nitrobenzoic Acid
- Purity
- 99.49%
- Packaging
- 10g
- Price
- $89
- Updated
- 2021/12/16
4-Iodo-3-nitrobenzoic acid Chemical Properties,Usage,Production
Uses
4-Iodo-3-nitrobenzoic acid is used as a pharmaceutical intermediate.
Synthesis
1588-83-6
35674-27-2
Example 1 Preparation of 4-iodo-3-nitrobenzoic acid (Compound V): 45 g (0.25 mol) of 4-amino-3-nitrobenzoic acid, 400 mL of deionized water and 100 mL of concentrated hydrochloric acid were added to a reaction flask. Stirring was turned on and the reaction mixture was cooled to 0 to 5 °C before 50 mL of an aqueous solution containing 25.9 g (0.38 mol) of sodium nitrite was slowly added dropwise. Gradual dissolution of the solid was observed. After the dropwise addition was completed, the reaction was maintained at 0 to 5°C and continued for 1 hour. Subsequently, 200 mL of an aqueous solution containing 88 g (0.5 mol) of potassium iodide was slowly added dropwise at the same temperature. After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 2 hours, during which time a solid precipitated. The solid product was collected by filtration, washed with deionized water and dried to give 65 g (0.22 mol) of 4-iodo-3-nitrobenzoic acid (compound V) in 89.7% yield.
References
[1] Patent: US2013/225810, 2013, A1. Location in patent: Paragraph 0081; 0082
[2] Tetrahedron, 2005, vol. 61, # 42, p. 10113 - 10121
[3] Tetrahedron Letters, 1997, vol. 38, # 46, p. 7963 - 7966
[4] Patent: WO2005/40157, 2005, A2. Location in patent: Page/Page column 67-68
[5] Patent: WO2010/62171, 2010, A2. Location in patent: Page/Page column 140
4-Iodo-3-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Iodo-3-nitrobenzoic acid manufacturers
- Product
- 4-Iodo-3-nitrobenzoic acid 35674-27-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-05
- Product
- 4-Iodo-3-nitrobenzoic acid 35674-27-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06
- Product
- 4-Iodo-3-nitrobenzoic acid 35674-27-2
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30